Protein Alignment PolH and polh-1

DIOPT Version :10

• Sequence 1: NP_649371.2
• Gene: PolH / 40438
• FlyBaseID: FBgn0037141
• Length: 885
• Species: Drosophila melanogaster
• Sequence 2: NP_497480.2
• Gene: polh-1 / 175337
• WormBaseID: WBGene00018721
• Length: 584
• Species: Caenorhabditis elegans
• Alignment Length: 613
• Identity: 172/613 - (28%)
• Similarity: 286/613 - (46%)
• Gaps: 95/613 - (15%)

  Fly    16 RVVLLVDMDCFFCQVEEKQHPEYRNRPLAVVQYNPWRG--GGIIAVNYAARAKGVTRHMRGDEAK 78
            ||:.|:|||||:.|||::.:|....:|:.|||::. :|  |||:||:|.||..||.|.|...|||
 Worm     3 RVISLIDMDCFYAQVEQRDNPSLWGQPVIVVQHSR-QGIEGGILAVSYEARPFGVKRGMTVAEAK 66

  Fly    79 DLCPEIVLCQVP--NIREKADTSKYRDAGKEVANVLQRFTQ--LLERASVDEAYLDITETVNHRM 139
            ..||:|.:|.||  ...:|||..|||||..||..||..:..  ::|:||||||:||::...|.::
 Worm    67 LKCPQISICHVPIGEYVDKADIQKYRDASAEVFRVLNNYDSQIIIEKASVDEAFLDLSAYTNQKL 131

  Fly   140 QQMQSGAFALQP--QELVNTFAVGYPSIGDYVNKITNRFANPYMDDERYQMSYDQNDLPAVRQSD 202
            |:::... .|:.  |..:......:.:.|:.|.:      |.::.:: ..:.|.:|.....  .:
 Worm   132 QELRENE-GLEEFLQAAITYLPTTHLATGEDVKE------NEHLRED-VLLEYIENARNCT--EN 186

  Fly   203 IRLLIGASVAGEVRAAVKKETGYECSAGIAHNKILAKLAAGMNKPNKQTILPLTETASLFDSLPV 267
            :.|||.|....::|..:.:||.:.||||:.:||::|||....:||.:||::|......:....|:
 Worm   187 LLLLIAAVTVEQIRQQIHEETQFFCSAGVGNNKMMAKLVCARHKPRQQTLIPWFYVREILRLTPI 251

  Fly   268 GKIKGLGGKFGEVVCETLGIKFMGQVVKFSEVDLQRKFD--EKNGTWLFNISRGIDLEAVTPRFY 330
            |.::|.|||.|..:.|.|.|..||:::   |||:.:..:  .....:|.:::.|...|.|.||..
 Worm   252 GDVRGFGGKMGNRIQEMLNITLMGELL---EVDISQLIETFPNQHEYLRSVAEGHCDEPVRPRKE 313

  Fly   331 SKSIGCCKKFPGRNNITGLKTLQHWLGELSSEINDRLEKDFIENNRRAKHMVVQYVQDIDGEEVA 395
            |.||...|.|||:.:|..:..|:.||..|:.|:..||..|..||.|.|:::|...:.: ||:
 Worm   314 SSSIAVSKNFPGKLSIRSVLELKKWLDGLTKELAKRLATDQAENKRTAENLVYSLLTE-DGK--- 374

  Fly   396 SSRSTALRDYDQESIVRLSLDLIKANTKTFLRPGSESA------LNNAIKFLGISVGKFETVSSG 454
            ..::..:..|..:::.......:|...||......:|.      ||     :.:|..:|:.....
 Worm   375 PQKTLKITSYHPDTLFEQIWAAMKGLNKTNATKNEDSGPWTPPILN-----ISLSATRFQPGIPA 434

  Fly   455 QNK-LQE-MFANQAAKKRRVSG--DE------------PGQLPKVEMEKKQKQTD-EFKMKSFFA 502
            ||: :.| ::..:..|.||.:.  ||            |.:|.|.....|...|| :|
 Worm   435 QNRSIHEWLYEKKTRKSRRKAAIYDENDGREDVIFVEPPEKLKKPNPTPKSTGTDGDF------- 492

  Fly   503 NYLQGAKKED-----------AKADGISANPLAAAAGAPNKNFVEEYKHKL-------------- 542
             .:.|:..:|           ...||...:.:|.....|  :..:.|:|::
 Worm   493 -IVLGSDSDDDVVQPKTDDNWIFVDGKKFSKMAWRHLPP--DIKKHYQHRIALEEARALKSKTGG 554

  Fly   543 ---HAAVRTEGTVLTSTPAEFKESFFSQ 567
               .|...|:.......|... ||||.:
 Worm   555 SRKRAGAHTDNAQKPKKPKSL-ESFFKK 581

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PolH	NP_649371.2	PolY_Pol_eta	20..447	CDD:176456	139/442 (31%)
		zf_UBZ	705..736	CDD:465769
		zf_UBZ	805..832	CDD:465769
polh-1	NP_497480.2	PolY	7..426	CDD:452909	139/441 (32%)