Protein Alignment PolH and rev-1

DIOPT Version :10

• Sequence 1: NP_649371.2
• Gene: PolH / 40438
• FlyBaseID: FBgn0037141
• Length: 885
• Species: Drosophila melanogaster
• Sequence 2: NP_495663.1
• Gene: rev-1 / 174275
• WormBaseID: WBGene00014066
• Length: 1027
• Species: Caenorhabditis elegans
• Alignment Length: 743
• Identity: 144/743 - (19%)
• Similarity: 242/743 - (32%)
• Gaps: 283/743 - (38%)

  Fly     9 SMQNKYDR--VVLLVDMDCFFCQVEEKQHPEYRNRPLAVVQYNPWRG------GGIIAVNYAARA 65
            |:.|:..|  .|..||:||||..|..:...:.:::.:|:...   :|      ..:.:.:||||.
 Worm   429 SLSNEISRESTVFHVDLDCFFVSVAVRNRIDLKHKEVAITHS---KGTISNSMSEVASCSYAARD 490

  Fly    66 KGVTRHMRGDEAKDLCPEIVLCQVPNIREKADTSKYRDAGKEVANVLQRFTQLLERASVDEAYLD 130
            .||...|...:|...||::.|  :|...|     .|....:::..:|..:|..:...|.||.|::
 Worm   491 CGVKNGMLVRDALQKCPQLTL--LPYQFE-----DYVQVSRKIYEILASYTLEVRAVSCDEMYIN 548

  Fly   131 ITETVNHRMQQMQSGAFALQPQELVNTFAVGYPSIGDYVNKITNRFANPYMDDERYQMSYDQNDL 195
                                    :::|.                        |:|::    ||
 Worm   549 ------------------------MSSFC------------------------EKYEI----ND- 560

  Fly   196 PAVRQSDIRLLIGASVAGEVRAAVKKETGYECSAGIAHNKILAKLAAGMNKPNKQTILPLTETAS 260
            |.:            :|..:|..::::|....|.||....:||:||....||:           .
 Worm   561 PTI------------LAEHIRKVIREKTQCPASVGIGSTSLLARLATRHAKPD-----------G 602

  Fly   261 LF--------DSLPVGKIKGLGGKFGEVVCETLGIKFMGQVVKFSEVDLQRK------FDEKNGT 311
            :|        :.:...|:|.|.| ||..:...| ..|.|.:.|..|:.|:.:      |..|..:
 Worm   603 VFWVNAHKKNEFISEEKVKDLPG-FGYEMMNRL-TSFFGDITKCRELQLKTERELVPVFGPKLAS 665

  Fly   312 WLFNISRGI-----DLEAVTPRFYSKSIGC----CKKFPGRNNITGLKTLQHWLGELSSEINDRL 367
            .:....|||     |..|...|   ||:.|    ..:|..|..:..|.|      .:.:|:..:|
 Worm   666 KILRQCRGIEEDPDDFWATHVR---KSVSCDINYGIRFTKRGEVIQLMT------AIGAELERKL 721

  Fly   368 EKDFIENNRRAKHMVVQYVQDIDGEEVASSRSTALRDYDQESIVRLSLDLIKAN----TKTFLRP 428
                                 ||.:..|.|             :.|.|.:..||    |..|:..
 Worm   722 ---------------------IDSKLTAGS-------------ITLKLMVRSANAPIQTSKFMGH 752

  Fly   429 G-----------------SESALNNAIKF-------------LGISVGKFET--VSSGQNKLQEM 461
            |                 .||..:.|:|.             :|::.||.::  .......:|||
 Worm   753 GICDTFTKTCNLNVPTTRGESLTSEAMKLYAKVSPKVEDLRGVGVTCGKLKSKLKKDAATAVQEM 817

  Fly   462 FANQAAKKRRVSGDEP-GQLPKVEMEKKQKQ------TDEFKMKSF-------FAN--------- 503
            |...:........||. ..:|:.|.|..::.      |::.:::|.       .||
 Worm   818 FGKTSRVGNMARTDEQLNIIPRNEDELDKEPVIIPAVTEDLEVQSIPRQINFRVANDIDIPEIVK 882

  Fly   504 --YLQG-----AKKEDAKADGISANPLA----AAAGAPNKNFVEEYKHKLHAAVRTEGTVLTSTP 557
              .|.|     .:.||.:.||:..|.||    .....|.|..|...:..|       .|:|....
 Worm   883 STLLNGRSDNNLELEDLEDDGLVENRLAELECIIQNEPTKESVTNLQEML-------STLLNYGK 940

  Fly   558 AEFKESFFSQYLKQQKKTGQQGSVTS------------------REDSLDVQEL----AEELDAI 600
            ....|:.|.::        ::.|:.|                  .|:|.|:.|.    ...|.|:
 Worm   941 LSAFETVFRKF--------EEISMDSSRCDTAWFSVFHLMVPFIEEESKDLLEFPIATTRNLGAM 997

  Fly   601 EADNSKDFEEDTEEETELTSDTHMSKPE 628
            .|.|              |.:|.:|.||
 Worm   998 IASN--------------TDNTSISSPE 1011

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PolH	NP_649371.2	PolY_Pol_eta	20..447	CDD:176456	93/489 (19%)
		zf_UBZ	705..736	CDD:465769
		zf_UBZ	805..832	CDD:465769
rev-1	NP_495663.1	BRCT	255..339	CDD:469589
		PolY_Rev1	381..802	CDD:176455	98/503 (19%)