DRSC/TRiP Functional Genomics Resources

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Protein Alignment Syn1 and SNTB2

DIOPT Version :9

Sequence 1:NP_001262192.1 Gene:Syn1 / 40424 FlyBaseID:FBgn0037130 Length:627 Species:Drosophila melanogaster
Sequence 2:NP_006741.1 Gene:SNTB2 / 6645 HGNCID:11169 Length:540 Species:Homo sapiens


Alignment Length:614 Identity:226/614 - (36%)
Similarity:317/614 - (51%) Gaps:124/614 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    30 RCGNMETRVRGAWYRVLVTLETDFLAVSLDESCEAAQPSNDGQSTTLNGTLGSNHSGGGGGGAGG 94
            :.|.:|..:|..|.||:..|..:.|:::.|.:....:|:....:...||.       ..||||| 
Human    24 KAGLVELLLRERWVRVVAELSGESLSLTGDAAAAELEPALGPAAAAFNGL-------PNGGGAG- 80

  Fly    95 GGTGGGGQNGTLPNSASLQGMNIQDTELDGSASNDNGDRDPCLNNNNNAGDGGGMDMCDVPDHVA 159
                                     ..|.||.|...|...|.......||:.|          .:
Human    81 -------------------------DSLPGSPSRGLGPPSPPAPPRGPAGEAG----------AS 110

  Fly   160 NQKRHVRIIKSDNNGLGISIKGGRENRMPILISKIFRGMAADQAKGLYVGDAILTVNGEELRDAT 224
            ...|.||::|.:..||||||||||||||||||||||.|:||||::.|.:|||||:|||.:||.||
Human   111 PPVRRVRVVKQEAGGLGISIKGGRENRMPILISKIFPGLAADQSRALRLGDAILSVNGTDLRQAT 175

  Fly   225 HDEAVRALKRSGRVVDLEVKFLREVTPYFRKASIISEVGWELQRAFLCPLGPGVPTSPP------ 283
            ||:||:||||:|:.|.|||||:||||||.:|.|::|::.||          ...|.||.      
Human   176 HDQAVQALKRAGKEVLLEVKFIREVTPYIKKPSLVSDLPWE----------GAAPQSPSFSGSED 230

  Fly   284 --APK-TTPRADTRYIPLQLTHLARNLKYIDPENRCFELHSPDGVHSCILRAADSAEALVWFNAL 345
              :|| .....|.:.|||::...||||...|.|||..||||||..::.|||..|:|.|..||.|:
Human   231 SGSPKHQNSTKDRKIIPLKMCFAARNLSMPDLENRLIELHSPDSRNTLILRCKDTATAHSWFVAI 295

  Fly   346 HSAMGTSTQRALAEANRAL--TNLIG---ELKHIGWLSK--RMSGGGSSGSAGGGAASGGSGTSN 403
            |:.:.....:.|||.|..|  |:..|   |:|||.||::  ::.||                   
Human   296 HTNIMALLPQVLAELNAMLGATSTAGGSKEVKHIAWLAEQAKLDGG------------------- 341

  Fly   404 SVVAGELVSPSGRSSSESSDESDKWLPIFVAVTEREFRIYESAPWSVEAWSRPLEIYALATTRL- 467
                                 ..:|.|:.:||||::..:|:..||:.:||:.|...|.|..||| 
Human   342 ---------------------RQQWRPVLMAVTEKDLLLYDCMPWTRDAWASPCHSYPLVATRLV 385

  Fly   468 -AGAGNNSSLNGQQTTVFCVRCGTARGVLVYWLRSETHRDMAAWARSLVQGSHQAVNYQREFSFR 531
             :|:|..|...|...| |..|.|:.:|:.::..|.|||||:::|.|.||||.|.|....:|.|..
Human   386 HSGSGCRSPSLGSDLT-FATRTGSRQGIEMHLFRVETHRDLSSWTRILVQGCHAAAELIKEVSLG 449

  Fly   532 CLFQGRQCQLVVHINRGFFL-YDCGGFAPTTPTVATAKTQLWQFAFDKLKGSADDGARMLYLDF- 594
            |:..|::.:|.:|...||.: .:.||          :.:.|:::.|::||.|||||.|.||||| 
Human   450 CMLNGQEVRLTIHYENGFTISRENGG----------SSSILYRYPFERLKMSADDGIRNLYLDFG 504

  Fly   595 GEDGEIELDMECCPKPVVFVVHNCLSAKV 623
            |.:||:.:|:..||||:|||:|..|||||
Human   505 GPEGELTMDLHSCPKPIVFVLHTFLSAKV 533

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Syn1NP_001262192.1 PH-like 30..>61 CDD:302622 9/30 (30%)
PDZ_signaling 163..244 CDD:238492 56/80 (70%)
PHsplit_syntrophin <293..351 CDD:269960 27/57 (47%)
SNTB2NP_006741.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 73..114 14/83 (17%)
PDZ_signaling 113..195 CDD:238492 56/81 (69%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 220..240 5/19 (26%)
PHsplit_syntrophin <244..301 CDD:269960 27/56 (48%)
PH 326..434 CDD:365918 42/148 (28%)
Calmodulin-binding. /evidence=ECO:0000250 518..540 12/16 (75%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165143874
Domainoid 1 1.000 160 1.000 Domainoid score I4079
eggNOG 1 0.900 - - E1_KOG3551
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 391 1.000 Inparanoid score I2000
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG45230
OrthoDB 1 1.010 - - D1261897at2759
OrthoFinder 1 1.000 - - FOG0003604
OrthoInspector 1 1.000 - - otm41001
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR10554
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2806
SonicParanoid 1 1.000 - - X1403
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1413.900

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