Protein Alignment Syn1 and SNTB2

DIOPT Version :10

• Sequence 1: NP_524205.2
• Gene: Syn1 / 40424
• FlyBaseID: FBgn0037130
• Length: 627
• Species: Drosophila melanogaster
• Sequence 2: NP_006741.1
• Gene: SNTB2 / 6645
• HGNCID: 11169
• Length: 540
• Species: Homo sapiens
• Alignment Length: 614
• Identity: 226/614 - (36%)
• Similarity: 317/614 - (51%)
• Gaps: 124/614 - (20%)

  Fly    30 RCGNMETRVRGAWYRVLVTLETDFLAVSLDESCEAAQPSNDGQSTTLNGTLGSNHSGGGGGGAGG 94
            :.|.:|..:|..|.||:..|..:.|:::.|.:....:|:....:...||.       ..|||||
Human    24 KAGLVELLLRERWVRVVAELSGESLSLTGDAAAAELEPALGPAAAAFNGL-------PNGGGAG- 80

  Fly    95 GGTGGGGQNGTLPNSASLQGMNIQDTELDGSASNDNGDRDPCLNNNNNAGDGGGMDMCDVPDHVA 159
                                     ..|.||.|...|...|.......||:.|          .:
Human    81 -------------------------DSLPGSPSRGLGPPSPPAPPRGPAGEAG----------AS 110

  Fly   160 NQKRHVRIIKSDNNGLGISIKGGRENRMPILISKIFRGMAADQAKGLYVGDAILTVNGEELRDAT 224
            ...|.||::|.:..||||||||||||||||||||||.|:||||::.|.:|||||:|||.:||.||
Human   111 PPVRRVRVVKQEAGGLGISIKGGRENRMPILISKIFPGLAADQSRALRLGDAILSVNGTDLRQAT 175

  Fly   225 HDEAVRALKRSGRVVDLEVKFLREVTPYFRKASIISEVGWELQRAFLCPLGPGVPTSPP------ 283
            ||:||:||||:|:.|.|||||:||||||.:|.|::|::.||          ...|.||.
Human   176 HDQAVQALKRAGKEVLLEVKFIREVTPYIKKPSLVSDLPWE----------GAAPQSPSFSGSED 230

  Fly   284 --APK-TTPRADTRYIPLQLTHLARNLKYIDPENRCFELHSPDGVHSCILRAADSAEALVWFNAL 345
              :|| .....|.:.|||::...||||...|.|||..||||||..::.|||..|:|.|..||.|:
Human   231 SGSPKHQNSTKDRKIIPLKMCFAARNLSMPDLENRLIELHSPDSRNTLILRCKDTATAHSWFVAI 295

  Fly   346 HSAMGTSTQRALAEANRAL--TNLIG---ELKHIGWLSK--RMSGGGSSGSAGGGAASGGSGTSN 403
            |:.:.....:.|||.|..|  |:..|   |:|||.||::  ::.||
Human   296 HTNIMALLPQVLAELNAMLGATSTAGGSKEVKHIAWLAEQAKLDGG------------------- 341

  Fly   404 SVVAGELVSPSGRSSSESSDESDKWLPIFVAVTEREFRIYESAPWSVEAWSRPLEIYALATTRL- 467
                                 ..:|.|:.:||||::..:|:..||:.:||:.|...|.|..|||
Human   342 ---------------------RQQWRPVLMAVTEKDLLLYDCMPWTRDAWASPCHSYPLVATRLV 385

  Fly   468 -AGAGNNSSLNGQQTTVFCVRCGTARGVLVYWLRSETHRDMAAWARSLVQGSHQAVNYQREFSFR 531
             :|:|..|...|...| |..|.|:.:|:.::..|.|||||:::|.|.||||.|.|....:|.|..
Human   386 HSGSGCRSPSLGSDLT-FATRTGSRQGIEMHLFRVETHRDLSSWTRILVQGCHAAAELIKEVSLG 449

  Fly   532 CLFQGRQCQLVVHINRGFFL-YDCGGFAPTTPTVATAKTQLWQFAFDKLKGSADDGARMLYLDF- 594
            |:..|::.:|.:|...||.: .:.||          :.:.|:::.|::||.|||||.|.|||||
Human   450 CMLNGQEVRLTIHYENGFTISRENGG----------SSSILYRYPFERLKMSADDGIRNLYLDFG 504

  Fly   595 GEDGEIELDMECCPKPVVFVVHNCLSAKV 623
            |.:||:.:|:..||||:|||:|..|||||
Human   505 GPEGELTMDLHSCPKPIVFVLHTFLSAKV 533

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Syn1	NP_524205.2	PH-like	30..>61	CDD:473070	9/30 (30%)
		PDZ_syntrophin-like	163..245	CDD:467262	57/81 (70%)
		PHsplit_syntrophin	<293..351	CDD:269960	27/57 (47%)
SNTB2	NP_006741.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	73..114		14/83 (17%)
		PDZ_syntrophin-like	114..196	CDD:467262	57/81 (70%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	220..240		5/19 (26%)
		PHsplit_syntrophin	<244..301	CDD:269960	27/56 (48%)
		PH	326..437	CDD:459697	45/151 (30%)
		Calmodulin-binding. /evidence=ECO:0000250	518..540		12/16 (75%)