DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Syn1 and grid2ipb

DIOPT Version :9

Sequence 1:	NP_001262192.1	Gene:	Syn1 / 40424	FlyBaseID:	FBgn0037130	Length:	627	Species:	Drosophila melanogaster
Sequence 2:	XP_009304908.1	Gene:	grid2ipb / 559717	ZFINID:	ZDB-GENE-040724-161	Length:	1383	Species:	Danio rerio

Alignment Length:	462	Identity:	92/462 - (19%)
Similarity:	147/462 - (31%)	Gaps:	144/462 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   118 QDTELDGSASNDNGD----RDPCLNNNNNAGDGGGMDMCDVPDHVAN--QKRHVRIIKSDNNGLG 176
            |.::...|...|.||    .|..|..:|..          :|....:  .:|.:|:.:. ....|
Zfish   294 QGSKRASSVPRDTGDEPAQNDRTLRKSNTM----------IPTQYVSGVNQRTIRVYRG-KKSFG 347

  Fly   177 ISIKGGRENRMPILISKIFRGMAADQAKGLYVGDAILTVNGEELRDATHDEAVRALKRSGRVVDL 241
            .:::|    ..|:.|..:..|..| :|.||..||.||.:||.::|:.:|::.|..|:.||.:..|
Zfish   348 FTLRG----HAPVWIDSVMPGSPA-EACGLKTGDRILFLNGLDMRNCSHEKVVSMLQGSGAMPSL 407

  Fly   242 EVKFLREVTPYFRKASIISEVGWELQRAFLCPLGP-GVPTSPPAPKTTP---------------- 289
                            ::.|             || ..|.|...|:.||
Zfish   408 ----------------VVEE-------------GPVDYPQSDSEPEETPSAPRSRSPALSSLQWV 443

  Fly   290 --------RADTRYIPLQLTHLARNLKYIDPENRC------FELHSPDGVHSCILRAADS-AEAL 339
                    |...|....||.||   |...:....|      |:..:.|.:...:....|: |:.|
Zfish   444 AEILPPSIRVHGRTFSQQLEHL---LTLQERYTICKALETFFQHRNVDTLIVDVFPVLDTPAKQL 505

  Fly   340 VW------------------------FNALHSAMGTSTQRALAEANRALTNLIGELKHIGWLSKR 380
            :|                        |.:....:|..|.|      |:.:..:....|...:.:|
Zfish   506 IWQFIYQLLTYEEQEHCKTKIARFLGFKSAEPEVGAETHR------RSSSMRVSGTSHKNTVRER 564

  Fly   381 MSGGGSSGSAGGGAASGGSGT-SNSVVAGELVSPSGRSSSESSDESDKWLPIFVAVTEREFRIYE 444
            .|.....|:      ..|.|| ::.|...|.....|.|..||.|     |.....|......:|.
Zfish   565 SSDDCIIGT------HLGMGTFTDPVTPEERQCGDGTSFPESPD-----LSHMTGVYTELGNVYP 618

  Fly   445 -SAPWSVEAWSRPLEIYALATTRLAGAGNNSSLNGQQTTVFCVRCGTARGVLVYWLRS------E 502
             .:..|:::.|.|         |.||.|...|....|:...........|:.:.|..|      |
Zfish   619 VKSSQSLQSHSSP---------RAAGMGLAESNTYTQSFTHSTAGNRKSGLSLTWTDSFPGPQFE 674

  Fly   503 THRDMAA 509
            |::...|
Zfish   675 TYQQTVA 681

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syn1	NP_001262192.1	PH-like	30..>61	CDD:302622
		PDZ_signaling	163..244	CDD:238492	24/80 (30%)
		PHsplit_syntrophin	<293..351	CDD:269960	14/88 (16%)
grid2ipb	XP_009304908.1	PDZ_signaling	9..69	CDD:238492
		PDZ_signaling	80..156	CDD:238492
		HN_L-delphilin-R1_like	183..262	CDD:259820
		PDZ_signaling	335..410	CDD:238492	24/96 (25%)
		HN_L-delphilin-R2_like	451..530	CDD:259821	14/81 (17%)
		FH2	995..1360	CDD:280362
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900