DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Syn1 and tamalin

DIOPT Version :9

Sequence 1:	NP_001262192.1	Gene:	Syn1 / 40424	FlyBaseID:	FBgn0037130	Length:	627	Species:	Drosophila melanogaster
Sequence 2:	NP_001035013.1	Gene:	tamalin / 558950	ZFINID:	ZDB-GENE-060312-30	Length:	382	Species:	Danio rerio

Alignment Length:	423	Identity:	80/423 - (18%)
Similarity:	137/423 - (32%)	Gaps:	137/423 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   115 MNIQDTELDGSASNDNGD-------RDPC--LNNN---------------------NNAGDGGGM 149
            :|..|.: .||..:|:||       .|.|  :|..                     .|....||:
Zfish    12 LNSSDPD-SGSLCHDSGDIYFTSSKSDSCGIVNRGPSNSTEVYNYKTLAYSGGTLPRNFKKNGGL 75

  Fly   150 D----MCDVPDHVANQKRHVRIIKSDNNGLGISIK-----GGREN--RMPILISKIFRGMAADQA 203
            .    :...|:   .|::.|.:.|.:....|..|:     ...||  .|...:.|:.....|..|
Zfish    76 QKWKPLAQSPE---PQRKTVILEKKEEESFGFEIQTYGLHHQSENSVEMCTFVCKVHEDSPALLA 137

  Fly   204 KGLYVGDAILTVNGEELRDATHDEAVRALKRSGRVVDLEVKFLREVTPYFRKASIISEV------ 262
             ||.|||.|.:||...:....|.|.|:.:|.||..:.||..:...:    |||.:.:.:
Zfish   138 -GLKVGDTIASVNDTSVDGFRHKEIVQLIKSSGNNIRLETVYSDSI----RKAELEARLQYLKQT 197

  Fly   263 ---GWELQRAFLC---------------------------PLGPGVPTSPPAPKTTPRADTRYIP 297
               .|:..|:.:.                           .||...|.:..|.:.|....:
Zfish   198 LHEKWDEYRSLMVQEQRLVHGIVMSDVAMYESLESAGVYGSLGAPSPAALRALRGTDSTSS---- 258

  Fly   298 LQLTHLARNLKYIDPENRCFELHSPDGVHSCILRAADSAEALVWFNALHSAMGTSTQRALAEANR 362
             .::||:......||      |:     .:||.....:       :.:|:....:..|.:..|:.
Zfish   259 -SVSHLSAATAEDDP------LY-----QTCIFNNTSN-------DQIHAKQENTRPRLIRPASE 304

  Fly   363 ALTNLIGELKHIGWLSKRMSGGGSSGSAGGGAASGGSGTSNSVVAGELVSPSGRSSSESSDESDK 427
            ..|.          ....::...|:.|.....:|..|.:|::|..||.....|.||.:...:
Zfish   305 LFTT----------AKTSLTRSASTRSYLRPPSSSSSASSSAVPNGEKQQCGGFSSLQRKPK--- 356

  Fly   428 WLPIFVAVTEREF--RIYESAPWSVEAWSRPLE 458
                     ::.|  |:.:..|    ..:||||
Zfish   357 ---------QKSFRRRLLKYIP----GLNRPLE 376

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syn1	NP_001262192.1	PH-like	30..>61	CDD:302622
		PDZ_signaling	163..244	CDD:238492	26/87 (30%)
		PHsplit_syntrophin	<293..351	CDD:269960	8/57 (14%)
tamalin	NP_001035013.1	PDZ_signaling	90..175	CDD:238492	24/85 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900