DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Syn1 and Pdzd3

DIOPT Version :9

Sequence 1:	NP_001262192.1	Gene:	Syn1 / 40424	FlyBaseID:	FBgn0037130	Length:	627	Species:	Drosophila melanogaster
Sequence 2:	NP_001178925.1	Gene:	Pdzd3 / 500986	RGDID:	1559807	Length:	498	Species:	Rattus norvegicus

Alignment Length:	284	Identity:	56/284 - (19%)
Similarity:	96/284 - (33%)	Gaps:	84/284 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   168 IKSDNNGLGISIK--GGRENRMPILISKIFRGMAADQAKGLYVGDAILTVNGEELRDATHDEAVR 230
            |:....|.|..::  .|.:.|:...:.::..|:.||:| |:..||.::.|.||.:....|:|.|.
  Rat   266 IEKGPQGFGFLLREEKGPDGRLGQFLWEVDPGLPADKA-GMKAGDRLVAVAGESMDGLGHEETVS 329

  Fly   231 ALKRSGRVVDLEVKFLREVTPYFRKASIISEVGWELQRAF-LCPLGPGVPTSPPAPKTTPRADTR 294
            .::..|..|.|.|     |.|             |..|.| :..|.|.:..........|.|:|:
  Rat   330 RIRAQGSCVSLVV-----VDP-------------EADRFFSMVRLSPLLFLENTEIAAAPLAETK 376

  Fly   295 YIPLQLTHLARNLKYIDP-----ENRCFELHSPDGVHSCILRAADSAEALVWFNALHSAMGTSTQ 354
            .:|::.|        ::|     ..:||....|.|.:...||...|...|
  Rat   377 DLPVEDT--------VEPSGLAGSRQCFLYPGPGGGYGFRLRCVASGPCL--------------- 418

  Fly   355 RALAEANRALTNLIGELKHIGWLSKRMSGGGSSGSAG----------GGAASGGSGTSNSVVAGE 409
                                  ...:::.|||:..||          .|...||....:::....
  Rat   419 ----------------------FISQVTPGGSAARAGLQMGDAILEVNGCPVGGDSDLDTLQQLA 461

  Fly   410 LVSPSGR--SSSESSDESDKWLPI 431
            ...|..|  .:..:|..|:.|:.:
  Rat   462 EAEPPLRLKLAPRNSQGSEAWISL 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syn1	NP_001262192.1	PH-like	30..>61	CDD:302622
		PDZ_signaling	163..244	CDD:238492	21/77 (27%)
		PHsplit_syntrophin	<293..351	CDD:269960	12/62 (19%)
Pdzd3	NP_001178925.1	PDZ_signaling	47..127	CDD:238492
		PDZ_signaling	155..232	CDD:238492
		PDZ	260..345	CDD:214570	23/84 (27%)
		PDZ_signaling	407..472	CDD:238492	14/101 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900