DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Syn1 and a

DIOPT Version :9

Sequence 1:	NP_001262192.1	Gene:	Syn1 / 40424	FlyBaseID:	FBgn0037130	Length:	627	Species:	Drosophila melanogaster
Sequence 2:	NP_001014543.1	Gene:	a / 43852	FlyBaseID:	FBgn0000008	Length:	1329	Species:	Drosophila melanogaster

Alignment Length:	524	Identity:	110/524 - (20%)
Similarity:	184/524 - (35%)	Gaps:	152/524 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 PIPQQHSPSPSGLRCGNMETRVRGAWYRVLVTLETDFLAVSLDESCEAAQPSNDGQS--TTLNGT 79
            |:||:.||..:.|.                        .||.::|.    .|.|.:.  ..|:..
  Fly   643 PLPQRRSPEQAMLN------------------------NVSRNDSI----TSKDWEPLYQRLSSC 679

  Fly    80 LGSNHSGGGGGGAGGGGTGGGGQNGTLPNSASLQGMNIQDTELDGSASNDNGDRDPCLNNNNNAG 144
            |.||.|   |..:.||.||     ..|.|:.|:.|   .|||   |.::....|:..::.:::.|
  Fly   680 LSSNES---GYDSDGGATG-----ARLGNNLSISG---GDTE---SIASGTLKRNSLISLSSSEG 730

  Fly   145 DGGGMDM--------------CDVP------------DHVANQKRHVRI---IKSDNNGLGISIK 180
            .|.||.|              |..|            :.:..:.|.|::   .:.|..|:.:|.|
  Fly   731 VGMGMGMSLGLGAPSTRNSSICSAPVSLGGYNYDYETETIRRRFRQVKLERKCQEDYIGIVLSPK 795

  Fly   181 ----GGRENRMPILISKIF-RGMAADQAKGLYVGDAILTVNGEELRDATHDEAVRALKRS--GRV 238
                ...|.:...||.::. .|||....: |.:||.|:.|||:.||.......|:.|..|  ...
  Fly   796 TVMTNSNEQQYRYLIVELEPYGMAQKDGR-LRLGDEIVNVNGKHLRGIQSFAEVQRLLSSFVDNC 859

  Fly   239 VDLEVKF--LREVTPYFRKASIISEVGWELQRAFLCPLGPGVPTSPPAPKTTPRADTRYIP-LQL 300
            :||.:..  :..||.::.|..|                 .|:        :|.|....|:. .|.
  Fly   860 IDLVIAHDEVTTVTDFYTKIRI-----------------DGM--------STQRHRLSYVQRTQS 899

  Fly   301 THLARNLKYIDPENRCFELHSPD------GVHSCILRAADSAEALVWFNALHSAMGTSTQRALAE 359
            |....:::.:..:....:.|:.:      |...|..|:..|...:.....|.....:||.|...:
  Fly   900 TDSLSSMQSLQLQQERIQGHNTEQEQEAQGEDQCDARSMASVSTMPTPMPLMQHRRSSTPRHSLD 964

  Fly   360 ANRALTNLIGELKHIGWLSKRMSGGGSSGSAGGGA---ASGGSGTSNSVVAGELVSPSGR---SS 418
                    :|..:|.....:..|..|....|....   |||.|..|:        ||:.|   :.
  Fly   965 --------VGAPEHELLRRRARSSSGQRSLALTPTPLFASGSSSCSS--------SPNHRLLDNE 1013

  Fly   419 SESSDESDKWLPIF------VAVTEREFRIYESAPWSVEAWSRPLEIYALATTRLAGAGNNSSLN 477
            ::.::::|.:.|::      |.|..   .:.:...|.:.|..|..|..||:.|      .|....
  Fly  1014 NDPANDTDSYTPVYANRAASVCVAS---SLADDEKWQLLARKRCSEGSALSAT------PNPQQF 1069

  Fly   478 GQQT 481
            ||:|
  Fly  1070 GQRT 1073

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syn1	NP_001262192.1	PH-like	30..>61	CDD:302622	2/30 (7%)
		PDZ_signaling	163..244	CDD:238492	26/90 (29%)
		PHsplit_syntrophin	<293..351	CDD:269960	9/64 (14%)
a	NP_001014543.1	PDZ_signaling	775..865	CDD:238492	26/90 (29%)
a	NP_001014543.1	PDZ_signaling	1230..1317	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900