Protein Alignment Syn1 and PsGEF

DIOPT Version :9

• Sequence 1: NP_001262192.1
• Gene: Syn1 / 40424
• FlyBaseID: FBgn0037130
• Length: 627
• Species: Drosophila melanogaster
• Sequence 2: NP_996333.4
• Gene: PsGEF / 31224
• FlyBaseID: FBgn0264598
• Length: 2777
• Species: Drosophila melanogaster
• Alignment Length: 598
• Identity: 118/598 - (19%)
• Similarity: 189/598 - (31%)
• Gaps: 189/598 - (31%)

  Fly     3 ESSSLGRTPPAAQQPI--PQQHSPSPSGLR------------------CGNMETRVRGAWYRVLV 47
            :|.|:...||...:|:  .::..||..|.:                  ..|:.|...|.  |.|:
  Fly  2082 DSESVPPAPPLVPRPVVPDREEDPSAEGQQENLAMEDQEDLHSSVERLLPNLATSAMGP--RPLL 2144

  Fly    48 T---LETDFL-----AVSLDESCEAAQPSNDGQSTTLNGTLGSNHSGGGGGGAGGGGTGGGGQNG 104
            |   |.|..:     ||.:..|||.              .|....|...|....||..|......
  Fly  2145 TTRLLPTTAIDPQPPAVLVASSCEY--------------LLDQRPSSVPGRDLAGGSIGTTTMTS 2195

  Fly   105 TLPN-------SASLQGMNIQDTELDGSASNDNGDRDP--CLNNNNNAGD---GGGMDMCDVPDH 157
            :.|.       :|:..|||...|....:.:.....|.|  .::..::|.|   .||......|..
  Fly  2196 SRPTPLSPAKAAATPIGMNATMTTKTTTTTMMTPSRAPSSTISTISSASDTTSSGGRASGRPPRF 2260

  Fly   158 VANQKRHVRIIKSDNNGLGISIKGGRENRMPILISKIFRGMAADQAKGLYVGDAIL----TVNGE 218
            |.......|::.:..:    .|.|..:..:|...|    |..||....:.||||..    |..|.
  Fly  2261 VPPPPPPRRLLLTQTD----LIAGQAKTELPRKKS----GATADSGCSVAVGDAASASDPTAIGS 2317

  Fly   219 ELRDATHD-----EAVRALKRSGRVVDL-------------------EVKFLREVTPYFRKASII 259
            ....:|..     .||...:.|..:::.                   ..|.:|:..|...::.
  Fly  2318 RTMPSTPSTSSLASAVAPKRPSSTIIETCLLGAPRPASATSSATASRMAKPIRQSPPTQHQSQ-- 2380

  Fly   260 SEVGWELQRAFLCPLGPGVPTSPPAPKTT---------PRADTRYIPLQLTHLARNLKYIDPENR 315
                         |.|...|.:.|||.|.         |.|.....|.....||.|...:..|:.
  Fly  2381 -------------PRGQSCPAAVPAPSTAAPDAPTVPMPHAGCGLSPRLEMRLALNHDILGDEDL 2432

  Fly   316 -CFE---------------LHSPDGVHSCILRAADS----AEALVWFNALHS------------- 347
             |:|               .|...| ...:.|:|.:    .||::.::...:
  Fly  2433 ICYEPGPDLTTILGHDLSTFHRLTG-RDLLSRSATNRVQPKEAVISYSQQRNSKMDTPTVNRRPR 2496

  Fly   348 -----AMGTSTQRALAEANRALTN-----LIGELKHIGW--LSKR----MSGGGSSGSAGGGAAS 396
                 |:|.||..:....:|:.::     |.|.|...|.  :.::    .:||||:|..|||:.|
  Fly  2497 PLSAGALGGSTSNSNPNNSRSSSSHGNSPLGGGLTRAGVEPVGQQQLVVQAGGGSAGRVGGGSGS 2561

  Fly   397 -GGSGTSNSVVAGELVSPSGRSSSESSDESDKWLPIFVAVTEREFRIYESAP----WSVEAWSRP 456
             ||:.|:.|         |.|..|:..|         :.:..|..:||..:.    ..|...:..
  Fly  2562 AGGNSTACS---------SNRGGSKLGD---------LEILARREKIYSMSQSRSGCRVRETTST 2608

  Fly   457 LEIYALATTRLAG 469
            ..:.|:||...:|
  Fly  2609 TTLMAMATEMRSG 2621

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Syn1	NP_001262192.1	PH-like	30..>61	CDD:302622	10/56 (18%)
		PDZ_signaling	163..244	CDD:238492	18/108 (17%)
		PHsplit_syntrophin	<293..351	CDD:269960	14/95 (15%)
PsGEF	NP_996333.4	DUF4799	<102..209	CDD:292674
		C2	286..>381	CDD:278593
		PDZ_signaling	644..716	CDD:238492
		RhoGEF	831..1000	CDD:295373

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900