DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Syn1 and FRMPD2

DIOPT Version :9

Sequence 1:	NP_001262192.1	Gene:	Syn1 / 40424	FlyBaseID:	FBgn0037130	Length:	627	Species:	Drosophila melanogaster
Sequence 2:	NP_001018081.4	Gene:	FRMPD2 / 143162	HGNCID:	28572	Length:	1309	Species:	Homo sapiens

Alignment Length:	309	Identity:	73/309 - (23%)
Similarity:	113/309 - (36%)	Gaps:	58/309 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    98 GGGGQNGTLP----NSASLQGMNIQDT---ELDGSASNDNGDRDPCLNNNNNAG----------- 144
            |.||.|   |    ||.:..|::..|.   ...||..:...|:|......:.||
Human   862 GVGGNN---PDEEKNSTANSGVSSTDILSFGYQGSLLSHTQDQDRNTEELDMAGVQSLVPRLRHQ 923

  Fly   145 ------DGGGMDMCDVPDHV-ANQKRHVRIIKSDNNGLGISIKGGRENRMP---ILISKIFRGMA 199
                  .|.|......|..: |.:...|.::|.|.. ||.|:.||....:|   |.:..|..|..
Human   924 LSFLPLKGAGSSCPPSPPEISAGEIYFVELVKEDGT-LGFSVTGGINTSVPYGGIYVKSIVPGGP 987

  Fly   200 ADQAKGLYVGDAILTVNGEELRDATHDEAVRALKRSGRVVDLEVKFLREVTPYFRKA-SIISEVG 263
            |.:...:..||.:|.|:|..|...||.:||:.|...|:|..|.::  |.|....::. |....:|
Human   988 AAKEGQILQGDRLLQVDGVILCGLTHKQAVQCLTGPGQVARLVLE--RRVPRSTQQCPSANDSMG 1050

  Fly   264 WELQRAFLCPLGPGVPTSPPAPKTTPRADTR-----------YIPLQ---LTHLARNLKYIDPEN 314
            .|.....|....||.|:|..:....|:.:.:           ::.::   .:||..:|..|   .
Human  1051 DERTAVSLVTALPGRPSSCVSVTDGPKFEVKLKKNANGLGFSFVQMEKESCSHLKSDLVRI---K 1112

  Fly   315 RCF-----ELHSPDGVHSCILRA-ADSAEALVWFNALHSAMGTSTQRAL 357
            |.|     |.:........||.. ..|.|.|::...||...|...:..|
Human  1113 RLFPGQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTL 1161

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syn1	NP_001262192.1	PH-like	30..>61	CDD:302622
		PDZ_signaling	163..244	CDD:238492	27/83 (33%)
		PHsplit_syntrophin	<293..351	CDD:269960	14/77 (18%)
FRMPD2	NP_001018081.4	KIND	15..197	CDD:214801
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	214..249
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	266..302
		B41	346..550	CDD:214604
		FERM_C_PTPH13	546..647	CDD:270008
		PDZ_signaling	773..857	CDD:238492
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	859..880		7/20 (35%)
		PDZ	947..1034	CDD:214570	27/89 (30%)
		PDZ	1078..1167	CDD:214570	16/87 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1204..1228
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900