DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Syn1 and AgaP_AGAP007865

DIOPT Version :9

Sequence 1:	NP_001262192.1	Gene:	Syn1 / 40424	FlyBaseID:	FBgn0037130	Length:	627	Species:	Drosophila melanogaster
Sequence 2:	XP_317627.4	Gene:	AgaP_AGAP007865 / 1278090	VectorBaseID:	AGAP007865	Length:	1707	Species:	Anopheles gambiae

Alignment Length:	526	Identity:	97/526 - (18%)
Similarity:	154/526 - (29%)	Gaps:	223/526 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 GSNHSGGGG------------------GGAGGGGTG----------------------------- 98
            |...|||||                  ||.||||||
Mosquito   924 GGGQSGGGGASASIANDALLSYPAAASGGGGGGGTGPAAMGHHSHGASMDYSAYRYSQIQSSKED 988

  Fly    99 -------GGGQNGTLPNSASLQGMNIQDTELDGSASNDNGDRDPCLNNNNNAGDG-----GGMDM 151
                   ||.:.||.|.:.|....|...........:..|.|.|...:..:.|.|     |.:|
Mosquito   989 VPISGYTGGYEGGTFPRNKSHLTSNSNHHHHHHHHHHQGGFRIPSNQSVTSRGSGIKISNGSID- 1052

  Fly   152 CD----------------VPDHV-------ANQKR--------------HVRIIKSDNNGLGISI 179
            |.                .|.|.       .:.||              .:|:::.|.:.:.:.|
Mosquito  1053 CSSSERASPIPTFEVQVLKPGHAPPGGGGPGSNKRSSLQDYGHSKPNVGELRLVQIDKSEMSLGI 1117

  Fly   180 K-GGRENRMPILISKIFRGMAADQAKGLYVGDAILTVNGEELRDATHDEAVRALKRSGRVVDLEV 243
            | ..|.|...:.:|.:.....|.:. ||::||.:|.|.|..||.||::.|...|::.|..:.:.|
Mosquito  1118 KIFCRRNGGGVFVSNVGENSLASKV-GLHIGDQLLEVCGINLRKATYELAAHVLRQCGNSITMLV 1181

  Fly   244 KFLREVTPYFRKASIISEVGWELQRAFLCPLGPGVPTS-PPAPKTTPRADTRYIPLQLTHLARNL 307
            .:    .|........||              ..|..| .|.|:.:||:           :.|:|
Mosquito  1182 LY----NPVVYSNLTTSE--------------DNVARSGSPTPQNSPRS-----------MGRSL 1217

  Fly   308 KYIDPENRCFELHSPDGVHSCILRAADSAEALVWFNALHSAMGTSTQRALAEANRALTNLIGELK 372
                                  :.|.::...    ||:...|......:|.:|.    .....|:
Mosquito  1218 ----------------------ISAVNTTAV----NAMTGTMTAPKTSSLVKAQ----EFSDSLE 1252

  Fly   373 HIGWLSKRMSGGGSSGSAGGGAASGGSGTSNSVVAGELVSPSGRSSSESSDESDKWLPIFVAVTE 437
            |    ..::......||...|::..|.|.||
Mosquito  1253 H----QTQLHDDEEDGSVAVGSSGVGGGQSN---------------------------------- 1279

  Fly   438 REFRIYESAPWSVEAWSRPLEIYALATTRLAGAGNNSSLNGQQTTVFCVRCGTARGVLVYWLRSE 502
                :|:         .:|.||| :.|.:.:..|  .:|.|          |.|.|:.|:.::.:
Mosquito  1280 ----MYK---------EQPREIY-IETRKTSNLG--ITLVG----------GNAYGIFVHGVQKD 1318

  Fly   503 THRDMA 508
            :..|.|
Mosquito  1319 SIADQA 1324

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syn1	NP_001262192.1	PH-like	30..>61	CDD:302622
		PDZ_signaling	163..244	CDD:238492	23/95 (24%)
		PHsplit_syntrophin	<293..351	CDD:269960	6/57 (11%)
AgaP_AGAP007865	XP_317627.4	SPEC	50..222	CDD:295325
		PDZ_signaling	225..320	CDD:238492
		PDZ_signaling	<341..405	CDD:238492
		PDZ	1102..1185	CDD:214570	23/87 (26%)
		PDZ_signaling	1285..1364	CDD:238492	14/53 (26%)
		SH3_DLG5	1382..1445	CDD:212794
		Guanylate_kin	1524..1694	CDD:279019
		NK	<1559..1695	CDD:302627
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900