Protein Alignment Syn1 and Pdzd7

DIOPT Version :9

• Sequence 1: NP_001262192.1
• Gene: Syn1 / 40424
• FlyBaseID: FBgn0037130
• Length: 627
• Species: Drosophila melanogaster
• Sequence 2: NP_001182194.1
• Gene: Pdzd7 / 100503041
• MGIID: 3608325
• Length: 1021
• Species: Mus musculus
• Alignment Length: 713
• Identity: 146/713 - (20%)
• Similarity: 235/713 - (32%)
• Gaps: 271/713 - (38%)

  Fly    22 HSPSPSGLRCGNMETRVRGAWYRVLVTL-------ETDFL-AVSLDESCEAAQPSNDGQSTTLNG 78
            :.|| .|:|..:...||      :|:..       |:|.: ||.:::|     ||         |
Mouse    52 NGPS-RGIRASSPMGRV------ILINSPIEANSDESDIIHAVRVEKS-----PS---------G 95

  Fly    79 TLGSNHSGGGGGGAG--------GGGTGGGGQNGTLPNSASLQGMNIQD--TELDGSA--SNDNG 131
            .||.:..||...|.|        |             :||...|:.:.|  ||::|.:  |...|
Mouse    96 RLGFSVRGGSEHGLGIFVSKVEEG-------------SSAERAGLCVGDKITEVNGLSLESTTMG 147

  Fly   132 DRDPCLNNNN-------NAGDGGG-------------------MDMC-DVPDHVANQKRHVRII- 168
            .....|.:::       ..|...|                   ::.| ..|...:::....||:
Mouse   148 SAVRLLTSSSCLHMMVRRMGRVPGIKFSKEKTTWVDVVNRRLVVEKCSSTPSDRSSEDGVRRIVH 212

  Fly   169 ---KSDNNGLGISIKGGRENRMPILISKIFRGMAADQAKGLYVGDAILTVNGEELRDATHDEAVR 230
               .||:..||.:|:||:|..:.|.:||:..|..|:: .|:.|||.:|..||....|.:|.:||.
Mouse   213 LYTTSDDFCLGFNIRGGKEFGLGIYVSKVDHGGLAEE-NGIKVGDQVLAANGVRFDDISHSQAVE 276

  Fly   231 ALKRSGRVVDLEVK------------------------FLREVTPYFRKASIISEVGWEL----- 266
            .||....:: |.:|                        .|::::|....:|.:|......
Mouse   277 VLKGQTHIM-LTIKETGRYPAYKEMVSEYCWLDRLSNGVLQQLSPASESSSSVSSYASSAPCSSG 340

  Fly   267 ----QRAFLCPLGPGVPTS--------PPAPKTTPRADTR---YIPLQLTHLARNLKYIDPENRC 316
                .|..:| |||..|||        ..|.:|.|..|:|   :..::.|.:.|:...
Mouse   341 SLPSDRMDVC-LGPEEPTSHGPGWGRADTAMQTEPDLDSRVETWCSVRPTVILRDTAI------- 397

  Fly   317 FELHSPDGVHSCILRAADSAEALVWFNALHSAMGTSTQRALAEA-NRALTNLIGELKHIG-WLSK 379
                ..||..|.              ..|.||:..|.:.||..| :|..|.:.....|:. |..|
Mouse   398 ----RSDGPSST--------------RHLDSALSESPKTALLLALSRPRTPITRSQSHLTLWEEK 444

  Fly   380 RMSGGGSSGSAGGGAASGGSGTSNSVV--AGELVSPSGRSSSESSDESDKWLPIFVAVTEREFRI 442
            :......|||:|...|...|.|..::.  .|....|:|....|:
Mouse   445 KQRKKEKSGSSGEKGALQRSKTLMNLFFKGGRQGRPAGDGHREA--------------------- 488

  Fly   443 YESAPWSVEAWS----RP---LE-------IYALATTRLAG---------AGNNSSLNGQQTTVF 484
                 |::::.|    ||   ||       :....|.||..         :..:.|.:||..||
Mouse   489 -----WTLDSRSPTKVRPRLDLEKAGSVGPVQKFVTWRLRRDRERGRALLSARSGSPSGQAPTV- 547

  Fly   485 CVRCGTARGVLVYWLRSETHRDMAAW--ARSLVQGSHQAVNYQREFSFRCLFQGRQCQLVVHINR 547
                               :..:.||  .|.|:|          :.:.|.|.......:..|.:|
Mouse   548 -------------------NEQVQAWESRRPLIQ----------DLARRLLTDDEVLAVTRHCSR 583

  Fly   548 GFFLYDCGGFAPTTPTVA-----------------TAKTQLWQF----------AFDKLKGSA 583
              ::::.|......|.:|                 .|.|.|.:|          ||:.||..|
Mouse   584 --YVHEGGVEDLVRPLLAILDRPTKLLLLRDIRSVVAPTDLGRFDSMVMPVELEAFEALKSRA 644

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Syn1	NP_001262192.1	PH-like	30..>61	CDD:302622	8/38 (21%)
		PDZ_signaling	163..244	CDD:238492	29/84 (35%)
		PHsplit_syntrophin	<293..351	CDD:269960	9/60 (15%)
Pdzd7	NP_001182194.1	PDZ_signaling	84..164	CDD:238492	23/106 (22%)
		PDZ_signaling	209..289	CDD:238492	29/81 (36%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	324..345		2/20 (10%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	431..495		15/89 (17%)
		HN_PDZD7_like	554..631	CDD:259824	15/88 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	724..814
		PDZ_signaling	856..944	CDD:238492
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	992..1021

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910