DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Syn1 and sntg2

DIOPT Version :9

Sequence 1:	NP_001262192.1	Gene:	Syn1 / 40424	FlyBaseID:	FBgn0037130	Length:	627	Species:	Drosophila melanogaster
Sequence 2:	XP_031758613.1	Gene:	sntg2 / 100495165	XenbaseID:	XB-GENE-988144	Length:	551	Species:	Xenopus tropicalis

Alignment Length:	592	Identity:	133/592 - (22%)
Similarity:	223/592 - (37%)	Gaps:	162/592 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   120 TELDGSASNDNGDRDPCLNNNNNAGDG-------GGMDMCDV---------------------PD 156
            |||:.......|::............|       |..:.|||                     .|
Frog    13 TELEAQEPEQGGEKQGQCPRAQQTKTGFAQLYNEGSENACDVRLKLTKEALTIQKQDVICVSGSD 77

  Fly   157 HVANQKRHVRIIKSDNNGLGISIKGGRENRMPILISKIFRGMAADQAKGLYVGDAILTVNGEELR 221
            ...| :|.|.:.:....|||:|||||.::::|::|||||:...||:...|::|||::.|||..:.
Frog    78 QSTN-RRTVTLHRHPIGGLGLSIKGGAQHKVPVVISKIFKDQPADKTGMLFIGDAVMQVNGINVE 141

  Fly   222 DATHDEAVRALKRSGRVVDLEVKFLREVTPYFRKASIISEVGWELQRAFLCPLG-PGVP------ 279
            :|||:|.|..|:.:|..|.:.|.:|:: ||.|.|                .||| |..|
Frog   142 NATHEEVVHLLRNAGDEVTITVYYLKD-TPSFLK----------------LPLGSPDPPSDHSSG 189

  Fly   280 ------------------TSPPAPKTTPRADTRY---------IPLQLTHLAR-NLKYIDPENRC 316
                              |:|.:|.:......||         |||.:..::| .:..:......
Frog   190 ASSPLFDSGLHLNGNISNTAPSSPSSPTVKQARYEKRWIDALSIPLLMARISRFRVSTVKLRRNS 254

  Fly   317 FELHSPDGVHSCILR---AADSAEALVWFNALHSAMGTSTQRALAEANRALTNLIGELKHIGWLS 378
            |||.:.||:.|.||:   |.|||:   |..|:.:.:...|.:.:...|:.. ::..::.|:||:|
Frog   255 FELLALDGISSGILQFNTAHDSAD---WLRAISTNINDLTLQNMKMINKCY-SMCDQIIHMGWVS 315

  Fly   379 KRMSGGGSSGSAGGGAASGGSGTSNSVVAGELVSPSGRSSSESSDESDKWLPIFVAVTEREFRIY 443
            :::.|                                      ||.|..:...|:.:....|.|:
Frog   316 EKVQG--------------------------------------SDGSHMYKFKFLVLKGSSFYIF 342

  Fly   444 ESAPWSVEAWSRPLEIYALATTRL------------------AGAGNNSSLNGQQTTVFCVRCGT 490
            ::.|.|...|.|..:||.|.....                  .....|..|..|:...|.:..|.
Frog   343 KTPPVSTLDWVRAEKIYNLCEVLFKVSKVWPADEIWIQENLYLNHNQNEELEEQRPYCFSILVGH 407

  Fly   491 ARGVLVYWLRSETHRDMAAWARSLVQGSHQAVNYQREFSFRCLFQGRQCQLVVHINRGFFLYDCG 555
            .:.   ::...|...|:....:|..:.....|......::.|..||......|....||..:|
Frog   408 GKS---HYFSVELGSDLPVLEKSFQKAIFMEVQRTGSKTYVCSSQGEVVCFTVDFISGFTCFD-- 467

  Fly   556 GFAPTTPTVATAKTQLWQFAFDKLKGSADDGARMLYLDFGEDGEIELDMECCP----KPVVFVVH 616
                     :.:|..:|:|.|.:||||:|||...:.|.|......:::|:...    ..|:..:|
Frog   468 ---------SKSKNIIWRFKFSQLKGSSDDGKTRVKLLFQSPDTKQIEMKELEFQDLTAVLHCIH 523

  Fly   617 NCLSAKV 623
            :.::|||
Frog   524 SFIAAKV 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syn1	NP_001262192.1	PH-like	30..>61	CDD:302622
		PDZ_signaling	163..244	CDD:238492	33/80 (41%)
		PHsplit_syntrophin	<293..351	CDD:269960	20/70 (29%)
sntg2	XP_031758613.1	PDZ_signaling	83..163	CDD:238492	33/79 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910