DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Syn1 and pdzrn3a

DIOPT Version :9

Sequence 1:	NP_001262192.1	Gene:	Syn1 / 40424	FlyBaseID:	FBgn0037130	Length:	627	Species:	Drosophila melanogaster
Sequence 2:	XP_001921128.3	Gene:	pdzrn3a / 100149029	ZFINID:	ZDB-GENE-090313-307	Length:	1033	Species:	Danio rerio

Alignment Length:	359	Identity:	82/359 - (22%)
Similarity:	129/359 - (35%)	Gaps:	134/359 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   172 NNGLGISIKGGR---------ENRMPILISKIFRGMAADQAKGLYVGDAILTVNGEELRDATHDE 227
            :..||.||.|||         :....|.||||....|||:| ||.|.|.|..:||..|..||||:
Zfish   252 SGSLGFSIIGGRLCEELDEHGDFSDGIYISKIVENGAADKA-GLCVHDRITKINGRSLSIATHDQ 315

  Fly   228 AVRALKRSGRVVDLEVKFLREVT-----------------------PYFRKASIISEVGWELQRA 269
            ||.|.:.:...:::||  ||.||                       .|.:....::::
Zfish   316 AVEAFQTTEDPIEVEV--LRRVTHKTCKPLKPVCGMDNSTQTNITLQYLKHIETMAQL------- 371

  Fly   270 FLCPLGPGVPTSPP---------APK--TTPRADTRYIP-----LQLTHLARNLKY--IDPENR- 315
                  |. ||:||         :||  ...|.|:.|.|     ::....::.|:|  :|.:.:
Zfish   372 ------PS-PTTPPSIAILNGFCSPKQCQKTRCDSPYPPDFDDGVEKDIESKGLEYEEVDLQRKN 429

  Fly   316 ---------CFELH-----------SPDGVHSCILRAAD----SAEALVWFNALHSAMGTSTQR- 355
                     |:::.           .|:||     .|.|    ..:.::..|      |...|.
Zfish   430 IQDKFGLMLCYKMDDEKTTIYVSKIDPEGV-----AAKDGRIQEGDQIIQIN------GEEVQSH 483

  Fly   356 --ALA----EANRALTNLIG--ELKHIGWLSKRMSGG------------------GSSGSAGGGA 394
              |:|    |.::.:..|:.  |.:.:.||.:.:..|                  .|:....||.
Zfish   484 EVAVALLTKEDSKNVAILVARPERQDVCWLEEDLKLGILEQLNDKVKEFDTSMLQQSTREEDGGT 548

  Fly   395 ASGGSGTSNSVVAGELVSPSGRS-SSESSDESDK 427
            ....:..||.   .|..|..||: .|..:|||.:
Zfish   549 TDTATLLSNH---HEKDSGVGRTDESTRNDESSE 579

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syn1	NP_001262192.1	PH-like	30..>61	CDD:302622
		PDZ_signaling	163..244	CDD:238492	32/80 (40%)
		PHsplit_syntrophin	<293..351	CDD:269960	12/89 (13%)
pdzrn3a	XP_001921128.3	RING	15..76	CDD:302633
		Sina	76..>131	CDD:302762
		PDZ	242..334	CDD:214570	34/84 (40%)
		PDZ_signaling	422..503	CDD:238492	14/91 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910