DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11247 and Zscan2

DIOPT Version :9

Sequence 1:	NP_001097659.1	Gene:	CG11247 / 40414	FlyBaseID:	FBgn0037120	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_001369440.1	Gene:	Zscan2 / 22691	MGIID:	99176	Length:	614	Species:	Mus musculus

Alignment Length:	465	Identity:	142/465 - (30%)
Similarity:	206/465 - (44%)	Gaps:	70/465 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 VRSRRSVSKEDAVSLLTD-------SGISLSSPPAARES--------SPGPTLAIKRRKSSLASL 51
            ::..|..|.|:||:|:.|       |...:.|......:        |.|..|.|...:....|.
Mouse   109 LQEHRPESSEEAVALVEDLTQTFRHSDFEIQSENGENSNEDMFEGVESHGMFLNISGGEGGQQSD 173

  Fly    52 RDACVDEEEDDGGEQ------DSK---------------------DDDYVQPQLKKS-ARKGEPV 88
            .|:..:.:...||.|      |.:                     :..|..||..|: :||...:
Mouse   174 GDSDFERDCGSGGAQGHAPGEDPRVVPSEGREVGQLIGLQGTYLGEKPYECPQCGKTFSRKSHLI 238

  Fly    89 K-------RKHHVCSQCSKEFGGKTDLQRHMLIHSDERPHKCKDCGKSYRQAVNLKNHITTAHEH 146
            .       .|::.|.:|.|.|...::..||...|:.|:|:||:|||||:.::.||..| ...|..
Mouse   239 THERTHTGEKYYKCDECGKSFSDGSNFSRHQTTHTGEKPYKCRDCGKSFSRSANLITH-QRIHTG 302

  Fly   147 RKQFVCSQCPKSFALKERLRLHMRLHSGEKPYPCDLCDKKFARGGQLQQHMVSHHKTSIQQFNCT 211
            .|.|.|::|.|||:....|..|.|.|:|||||.|..|.|.|.....|..|...|  |..:.:.|.
Mouse   303 EKPFQCAECGKSFSRSPNLIAHQRTHTGEKPYSCPECGKSFGNRSSLNTHQGIH--TGEKPYACK 365

  Fly   212 KCSASFSTNANLRVHMERHEQGMEHRCSICENQFANELALRAHINQEHHKLTQFECEICHKMIEP 276
            :|..|||.|:||..|...|.....::|:.|..:|:...||..| .:.|.....::|..|.|....
Mouse   366 ECGESFSYNSNLIRHQRIHTGEKPYKCTECGQKFSQSSALITH-RRTHTGEKPYQCGECGKNFSR 429

  Fly   277 DEDLATHMQRHTAVKTHVCEVCNTYFTQKSQYNVHMRMHTGERPYQCRICHQTFAHSSVLKLHIR 341
            ..:||||.:.|...|.:.|.:|...|:|.|....|...||||:||:|..|.::|:.||.|..|.|
Mouse   430 SSNLATHRRTHLVEKPYKCGLCGKSFSQSSSLIAHQGTHTGEKPYECLTCGESFSWSSNLIKHQR 494

  Fly   342 KHTGEKPFRCQLCEDEVAFSQLAHLKNHMKKIHKQQKPYMCEGCHDFFK----IKVELQSHVEHC 402
            .||||||:||..|..  .|||.:.|..| ::.|..:|||.|..|...|.    :.:..::|:
Mouse   495 THTGEKPYRCGDCGK--GFSQRSQLVVH-QRTHTGEKPYKCLMCGKSFSRGSILVMHQRAHL--- 553

  Fly   403 AKCPVDGDKP 412
                  ||||
Mouse   554 ------GDKP 557

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11247	NP_001097659.1	COG5048	<88..247	CDD:227381	58/165 (35%)
		C2H2 Zn finger	95..115	CDD:275368	6/19 (32%)
		zf-H2C2_2	107..132	CDD:290200	12/24 (50%)
		C2H2 Zn finger	123..144	CDD:275368	9/20 (45%)
		C2H2 Zn finger	152..172	CDD:275368	8/19 (42%)
		zf-H2C2_2	165..189	CDD:290200	13/23 (57%)
		C2H2 Zn finger	180..200	CDD:275368	6/19 (32%)
		COG5048	<192..369	CDD:227381	63/176 (36%)
		C2H2 Zn finger	210..230	CDD:275370	9/19 (47%)
		C2H2 Zn finger	238..260	CDD:275371	6/21 (29%)
		C2H2 Zn finger	267..287	CDD:275368	7/19 (37%)
		C2H2 Zn finger	295..315	CDD:275368	6/19 (32%)
		zf-H2C2_2	309..332	CDD:290200	10/22 (45%)
		C2H2 Zn finger	323..343	CDD:275368	8/19 (42%)
		C2H2 Zn finger	351..374	CDD:275368	7/22 (32%)
		C2H2 Zn finger	382..399	CDD:275368	3/20 (15%)
Zscan2	NP_001369440.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..25
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	42..73
		SCAN	69..131	CDD:396558	7/21 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	162..200		7/37 (19%)
		COG5048	220..600	CDD:227381	123/354 (35%)
		C2H2 Zn finger	224..244	CDD:275368	5/19 (26%)
		C2H2 Zn finger	252..272	CDD:275368	6/19 (32%)
		C2H2 Zn finger	280..300	CDD:275368	9/20 (45%)
		C2H2 Zn finger	308..328	CDD:275368	8/19 (42%)
		C2H2 Zn finger	336..356	CDD:275368	6/19 (32%)
		C2H2 Zn finger	364..384	CDD:275368	9/19 (47%)
		C2H2 Zn finger	392..412	CDD:275368	6/20 (30%)
		C2H2 Zn finger	420..440	CDD:275368	7/19 (37%)
		C2H2 Zn finger	448..468	CDD:275368	6/19 (32%)
		C2H2 Zn finger	476..496	CDD:275368	8/19 (42%)
		C2H2 Zn finger	504..524	CDD:275368	7/22 (32%)
		C2H2 Zn finger	532..552	CDD:275368	3/19 (16%)
		C2H2 Zn finger	560..580	CDD:275368
		C2H2 Zn finger	588..608	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910