DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11247 and ZNF431

DIOPT Version :9

Sequence 1:	NP_001097659.1	Gene:	CG11247 / 40414	FlyBaseID:	FBgn0037120	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	XP_011526052.1	Gene:	ZNF431 / 170959	HGNCID:	20809	Length:	593	Species:	Homo sapiens

Alignment Length:	339	Identity:	114/339 - (33%)
Similarity:	161/339 - (47%)	Gaps:	33/339 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 LKKSARKGEPVKRKHHVCSQCSKEFGGKTDLQRHMLIHSDERPHKCKDCGKSYRQ---------- 132
            |..|..|...::...:.|.:|.|.|...:.|.||..||:.|:|.||::|||:::|
Human   234 LHLSQHKRIHIRENSYQCEECGKAFKWFSTLTRHKRIHTGEKPFKCEECGKAFKQSSTLTTHKII 298

  Fly   133 --------------AVNLKNHITT---AHEHRKQFVCSQCPKSFALKERLRLHMRLHSGEKPYPC 180
                          |.|..:|:||   .|...|.:.|.:|.|:|.....|..|..:|:|||||.|
Human   299 HTGEKPYRCEECGKAFNRSSHLTTHKIIHTGEKPYKCEECGKAFNQSSTLSTHKFIHAGEKPYKC 363

  Fly   181 DLCDKKFARGGQLQQHMVSHHKTSIQQFNCTKCSASFSTNANLRVHMERHEQGMEHRCSICENQF 245
            :.|||.|.|...|.:|.:.|  |..:.:.|.:|...|:.::.|..|...|.....::|.:|...|
Human   364 EECDKAFNRFSYLTKHKIIH--TGEKSYKCEECGKGFNWSSTLTKHKRIHTGEKPYKCEVCGKAF 426

  Fly   246 ANELALRAHINQEHHKLTQFECEICHKMIEPDEDLATHMQRHTAVKTHVCEVCNTYFTQKSQYNV 310
            .....|..| ...|.....::||.|.|.......|..|...||..|.:.||.|...|:|.|....
Human   427 NESSNLTTH-KMIHTGEKPYKCEECGKAFNRSPQLTAHKIIHTGEKPYKCEECGKAFSQSSILTT 490

  Fly   311 HMRMHTGERPYQCRICHQTFAHSSVLKLHIRKHTGEKPFRCQLCEDEVAFSQLAHLKNHMKKIHK 375
            |.|:||||:||:|..|.:.|..||.|..|...|||||.::|:.|..  ||:|.:.|..| :|||.
Human   491 HKRIHTGEKPYKCEECGKAFNRSSNLTKHKIIHTGEKSYKCEECGK--AFNQSSTLTKH-RKIHT 552

  Fly   376 QQKPYMCEGCHDFF 389
            :||||.||.|.:.|
Human   553 RQKPYNCEECDNTF 566

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11247	NP_001097659.1	COG5048	<88..247	CDD:227381	55/185 (30%)
		C2H2 Zn finger	95..115	CDD:275368	7/19 (37%)
		zf-H2C2_2	107..132	CDD:290200	12/24 (50%)
		C2H2 Zn finger	123..144	CDD:275368	10/47 (21%)
		C2H2 Zn finger	152..172	CDD:275368	6/19 (32%)
		zf-H2C2_2	165..189	CDD:290200	13/23 (57%)
		C2H2 Zn finger	180..200	CDD:275368	8/19 (42%)
		COG5048	<192..369	CDD:227381	57/176 (32%)
		C2H2 Zn finger	210..230	CDD:275370	5/19 (26%)
		C2H2 Zn finger	238..260	CDD:275371	5/21 (24%)
		C2H2 Zn finger	267..287	CDD:275368	6/19 (32%)
		C2H2 Zn finger	295..315	CDD:275368	8/19 (42%)
		zf-H2C2_2	309..332	CDD:290200	11/22 (50%)
		C2H2 Zn finger	323..343	CDD:275368	7/19 (37%)
		C2H2 Zn finger	351..374	CDD:275368	8/22 (36%)
		C2H2 Zn finger	382..399	CDD:275368	4/8 (50%)
ZNF431	XP_011526052.1	KRAB	51..112	CDD:214630
		KRAB	51..90	CDD:279668
		zf-H2C2_2	209..230	CDD:290200
		COG5048	218..570	CDD:227381	114/339 (34%)
		C2H2 Zn finger	223..243	CDD:275368	3/8 (38%)
		C2H2 Zn finger	251..271	CDD:275368	7/19 (37%)
		zf-H2C2_2	264..288	CDD:290200	12/23 (52%)
		C2H2 Zn finger	279..299	CDD:275368	5/19 (26%)
		zf-H2C2_2	292..316	CDD:290200	1/23 (4%)
		C2H2 Zn finger	307..327	CDD:275368	5/19 (26%)
		zf-H2C2_2	319..344	CDD:290200	9/24 (38%)
		C2H2 Zn finger	335..355	CDD:275368	6/19 (32%)
		C2H2 Zn finger	363..383	CDD:275368	8/19 (42%)
		zf-H2C2_2	375..399	CDD:290200	6/25 (24%)
		C2H2 Zn finger	391..411	CDD:275368	5/19 (26%)
		zf-H2C2_2	404..427	CDD:290200	5/22 (23%)
		C2H2 Zn finger	419..439	CDD:275368	5/20 (25%)
		zf-H2C2_2	431..456	CDD:290200	7/25 (28%)
		C2H2 Zn finger	447..467	CDD:275368	6/19 (32%)
		zf-H2C2_2	460..484	CDD:290200	9/23 (39%)
		C2H2 Zn finger	475..495	CDD:275368	8/19 (42%)
		zf-H2C2_2	488..512	CDD:290200	11/23 (48%)
		C2H2 Zn finger	503..523	CDD:275368	7/19 (37%)
		zf-H2C2_2	515..540	CDD:290200	11/26 (42%)
		C2H2 Zn finger	531..551	CDD:275368	8/22 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910