DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Als2 and rsph10b

DIOPT Version :9

Sequence 1:	NP_649347.1	Gene:	Als2 / 40410	FlyBaseID:	FBgn0037116	Length:	1486	Species:	Drosophila melanogaster
Sequence 2:	NP_001070227.1	Gene:	rsph10b / 767792	ZFINID:	ZDB-GENE-060929-300	Length:	731	Species:	Danio rerio

Alignment Length:	821	Identity:	158/821 - (19%)
Similarity:	284/821 - (34%)	Gaps:	280/821 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   676 GDSLR---LTTPE----KSFLVSTRSQEMRKVWLD-----QLQSSIIASL---------GKPLGS 719
            ||:::   .:|||    |:.:.|:.|..:.:..::     .|.||.:.|.         .:|:|.
Zfish     4 GDNMKSSNKSTPEPTLSKTLVESSTSSLLSESVVEPEDGQDLSSSAVCSASTVSLPPNENQPIGE 68

  Fly   720 -----PVPSYRSTGYEFSREHPKFSRVKACGTWRKGVLHGNCYLEYPDGSVYCGELQHGIIEGFG 779
                 .||...|...|      ::...| ||.    :.||.....:..|.||.|...||::.|:|
Zfish    69 HDRCRTVPVLHSIIVE------RYEGEK-CGE----MFHGEGVAYFQGGHVYKGSFSHGLMHGYG 122

  Fly   780 KMVIPTTGLYVGNFKGGRFHGHGVYEMHCKDSPESEVYEGNFCEGLFHGHG---------VMRNN 835
            :.:......|.|:||.....|||.|..     .....|||...:|:.||.|         |.|..
Zfish   123 EYIWSDGLKYQGDFKVNVPMGHGTYTW-----LNGSTYEGEVHQGIRHGVGMYKCVKTLTVYRGQ 182

  Fly   836 RYI------------------YVGEYQANARSGYGVIEDLVSGDKYMGMFADNKRSGIGSCITNR 882
            .|:                  |.||:..|.|.|:|. ....||:.|.|.:.:|.|.|.|   |.|
Zfish   183 WYLGKRQGQGEMFYNQEATSWYKGEWVNNCREGWGK-RCYPSGNVYEGQWRNNVRHGEG---TMR 243

  Fly   883 GDYFEGSFSGDDLTGSGVAVFENDYY--------------YEGELTLLGPNGRGEYYMPSGDACG 933
            ....:..:||..:.|.......:.::              |.|:......:|:|::..
Zfish   244 WIDLDQQYSGQWINGIQEGKGTHTWFRKRAPSSQYPRMNEYTGDFVQAMRHGQGQFLY------- 301

  Fly   934 GSGAMGTGEFDDTCELIGNKMFGQLSGTWDTVRIQAGELVLNRRFPKYPSSLGRQVVDHNRKWRS 998
            .|||:..|::.      .:|..||                            ||.:.::.|.:..
Zfish   302 ASGALYCGQWK------YDKKHGQ----------------------------GRYIFENGRVYEG 332

  Fly   999 LFNNFESDLANCTASTSSSGGNQSAGTLRKSSKPTLSTAQIWNCIAVYMSKQRAREGTKPGNYFN 1063
            .|:.                                      :|:|.:.:......|
Zfish   333 EFSK--------------------------------------DCMAEFPAFTPGLSG-------- 351

  Fly  1064 NILLSLPLPQKTSSPLAKARTTTSA-------LSKLQT------EAASALDFLGFPPRRIQSQEA 1115
               ::.|.|.:..|....::::::|       :..:||      ||....:|.       |.:.|
Zfish   352 ---ITTPFPDENDSSKGASQSSSNASPLGSDMVLNIQTLLNRVSEAHREQEFK-------QVEFA 406

  Fly  1116 LNSKPGGLQRADSLI-SMGHNTSRDLDNSSLASFQLDQSLMNSTVNGDESSTFNESFSKLS-HNN 1178
            :....|.|:...|.. |:||..|.| ....|...|..:.|::..|: ....|..:.:|.:: |:.
Zfish   407 VLRHMGLLREIYSFYSSLGHEQSLD-KIFPLTHLQFSRFLLDCRVH-QHGVTLAQIYSLINVHSP 469

  Fly  1179 NNS------------ISKHMNNIDCSITSTTSTTSAVLDQVPSFGMALVLTEQDV----TSIRLY 1227
            ..:            |:.|:.:.|  |.|:.:..:|...:         |.:|::    .|::.:
Zfish   470 FTAILPRECISYIIIIAYHICHKD--IESSNNILAACFSK---------LMKQNIIPNAKSVKGH 523

  Fly  1228 LEQAFKDRHHPLYVLNERIANCFHYSYGYWKVKPTPILAKQAMREWESISRRIYRFVRKMFPALP 1292
            |      ..||::.     |...:||...|::       .||:.|..|:      |..:.|..:.
Zfish   524 L------FCHPVHA-----AVAMNYSDKSWEI-------YQALCEAHSV------FTVRQFVLML 564

  Fly  1293 EELCQMEGS---REVISHITLLYPLVLSEGIYSTL-----FVLYANKYSRKDEMYRQNLNLAEKL 1349
            ::||..:..   .::|..:::..| .:.:|.||.|     |:          |.:...|..|| |
Zfish   565 KDLCLYDNELTVSKLIRTLSVDSP-AIHDGTYSNLDLEMSFL----------EFFEALLGCAE-L 617

  Fly  1350 KDQELVELMGHESFLHNVMLDPKFVESVQTL-KELQEKFSP 1389
            |.|::      :|: .....|....:.:.:| ||.:::.||
Zfish   618 KGQKI------QSY-DESQTDASLQDHISSLSKEKEQRQSP 651

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Als2	NP_649347.1	RCC1	258..304	CDD:278826
		RCC1_2	292..321	CDD:290274
		RCC1	308..361	CDD:278826
		PH-like	616..715	CDD:302622	12/59 (20%)
		VPS9	1373..1479	CDD:280383	5/18 (28%)
rsph10b	NP_001070227.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..69		14/64 (22%)
		MORN 1	86..108		6/26 (23%)
		MORN 2	109..131		6/21 (29%)
		MORN	109..129	CDD:280628	6/19 (32%)
		MORN 3	132..154		8/26 (31%)
		MORN 4	155..177		7/21 (33%)
		MORN 5	179..201		2/21 (10%)
		COG4642	194..334	CDD:226989	34/184 (18%)
		MORN 6	204..226		9/22 (41%)
		MORN	225..246	CDD:197832	8/23 (35%)
		MORN 7	227..249		8/24 (33%)
		MORN 8	251..273		3/21 (14%)
		MORN 9	284..306		6/28 (21%)
		MORN 10	307..329		6/55 (11%)
		MORN	307..327	CDD:280628	6/53 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	353..377		4/23 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	709..731
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4642
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900