DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Als2 and rcc1l

DIOPT Version :9

Sequence 1:	NP_649347.1	Gene:	Als2 / 40410	FlyBaseID:	FBgn0037116	Length:	1486	Species:	Drosophila melanogaster
Sequence 2:	NP_001076272.1	Gene:	rcc1l / 555972	ZFINID:	ZDB-GENE-060526-370	Length:	451	Species:	Danio rerio

Alignment Length:	267	Identity:	53/267 - (19%)
Similarity:	93/267 - (34%)	Gaps:	104/267 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   129 PLELHAEGVRIRRVCC---------SAQGVVFVGASGETYVMGSCG------EVFKAEQQPRHMR 178
            || |:.:..|:.:|.|         .::||..:|::    ..|.||      ||:...    |:.
Zfish   154 PL-LNPQETRVPQVSCGRAHSLVLTDSEGVFSMGSN----TFGQCGRKIVEDEVYSGS----HVV 209

  Fly   179 LYEEG--KELLDLAAGNEHFVMLVAPYNLADDALQLSVASAKEEPEDERASVKSISSGHSERSVA 241
            ...||  ..::.:|.|.:|.:.|.                       :|.||
Zfish   210 HKIEGFDSRVIQVACGQDHSLFLT-----------------------DRGSV------------- 238

  Fly   242 ANTRHLLHQGYALLHTQLFTFGASNNGLLGSGDHIRRANV----------MRLQKLDSMGVCSIA 296
                              |..|...:|..|.|.| .:|:.          :.:|::.:.|.||:|
Zfish   239 ------------------FACGWGADGQTGLGHH-NKASCPVPVGGDLAGVTVQQVATYGDCSLA 284

  Fly   297 AGLEHTVARTLDGRLYHWGLNNHSQLGEDVSSPMEITITENTAALPIEQNSAL-EATCGDYHTLL 360
            .        :.||:::.||.:.:.||    :|..|.|...:...||::....: :|.||.....:
Zfish   285 V--------STDGQVFGWGNSEYLQL----ASVTESTQISSPRLLPLKGVGRIRQAACGGTQVAV 337

  Fly   361 LNASGQI 367
            ||..|.:
Zfish   338 LNEDGDV 344

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Als2	NP_649347.1	RCC1	258..304	CDD:278826	12/55 (22%)
		RCC1_2	292..321	CDD:290274	7/28 (25%)
		RCC1	308..361	CDD:278826	14/53 (26%)
		PH-like	616..715	CDD:302622
		VPS9	1373..1479	CDD:280383
rcc1l	NP_001076272.1	RCC1	52..108	CDD:278826
		RCC1_2	165..192	CDD:290274	5/30 (17%)
		RCC1	182..232	CDD:278826	13/57 (23%)
		RCC1_2	219..248	CDD:290274	9/82 (11%)
		RCC1	236..285	CDD:278826	13/80 (16%)
		RCC1	288..338	CDD:278826	14/53 (26%)
		RCC1_2	383..412	CDD:290274
		RCC1	400..446	CDD:278826
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900