DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment LRP6 and mgl

DIOPT Version :9

Sequence 1:NP_001401173.1 Gene:LRP6 / 4040 HGNCID:6698 Length:1644 Species:Homo sapiens
Sequence 2:NP_572563.3 Gene:mgl / 8674055 FlyBaseID:FBgn0261260 Length:4769 Species:Drosophila melanogaster


Alignment Length:1457 Identity:460/1457 - (31%)
Similarity:727/1457 - (49%) Gaps:142/1457 - (9%)


- Green bases have known domain annotations that are detailed below.


Human    20 APLLLYANRRDLRLVD-ATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKRTEFNKT 83
            |..|:.:||..:.:.| ...|.|...|:|   |:..|.......|.|:|||:..:.|.|  .::.
  Fly  1560 AAFLIISNRHSILVADLKEQGLERVPIIV---ENVVATASNMHTGTIFWSDMKLKKISR--LDRG 1619

Human    84 ESVQNVVVSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQPRAIALDPS 148
            ...|.::.:||...:|||.||:.:.|||.||:.|.||||..:||.|.||..:.:.|||.:.:|||
  Fly  1620 MEPQEIINTGLDLVEGLAYDWIAQNLYWLDSKLNTIEVSAENGSNRLVLVRENITQPRGMCIDPS 1684

Human   149 SG--FMYWTDWGEVPKIERAGMDGSSRFIIINSEIYWPNGLTLDYEEQKLYWADAKLNFIHKSNL 211
            .|  :::||||||.|::||.||||:.|..|||::||||||||||...:::|:||:||:||.....
  Fly  1685 PGARWIFWTDWGENPRVERIGMDGTMRKTIINTKIYWPNGLTLDIATKRVYFADSKLDFIDFCYY 1749

Human   212 DGTNRQAVVKGS--LPHPFALTLFEDILYWTDWSTHSILACNKYTGEGLREIHSDIFSPMDIHAF 274
            :||.||.|:..|  |.||.:|:||||.|||||...:.:|:.||:.|:....:...|..|:.||..
  Fly  1750 NGTGRQQVLASSHYLLHPHSLSLFEDTLYWTDRQLNRVLSANKFRGKNQTVVSHLISQPLSIHVH 1814

Human   275 SQQRQPNATNPCGIDNGGCSHLCLMSPVKP-FYQCACPTGVKLLENGKTCKDGATELLLLARRTD 338
            ....||...|||.  ...|.||||:||..| .|.|.|..|.|||..|: |.:.....|::.:.|.
  Fly  1815 HASLQPMTPNPCA--GSRCQHLCLLSPSAPEGYSCKCRPGFKLLSEGR-CIEEENPFLMVVKGTQ 1876

Human   339 LRRISLDTPDF-TDIVLQLEDIRHAIAIDYDPVEGYIYWT-----DDEVRAIRRSFIDGSGSQFV 397
            :..:.|:..|. ...:..:..|..:..:|:|.....:||.     |||...|..:...|......
  Fly  1877 IVDLPLNGGDARAGALAPVIGIESSTGLDFDRKGETLYWVQGREDDDENCTIYTTPYGGGNKTLF 1941

Human   398 VTAQ---IAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTM--RKILISED-----LEEPRAIV 452
            :..:   :..|..||.||:.||||..:.....||..|::|..  |.|:::.|     :..|:.|.
  Fly  1942 LGIENGIVGAPYTIAFDWLGRNLYIGNRVASNIEAVRVDGKQKYRTIILANDGYPNSVSRPKQIA 2006

Human   453 LDPMVGYMYWTDWG--EIP-KIERAALDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKI 514
            |||..|.::|.|.|  |:| ||.|..::|.:.:| |......|..||:|.::..:|:..:....|
  Fly  2007 LDPTEGKLFWIDEGVLEVPIKIGRVDMNGQNPIV-VFQEFAHPESLAVDTEKKMVYYSASNPAVI 2070

Human   515 EVMNTDGTGRR-VLVEDK----IPHIFGFTLLGDYVYWTDWQRRSIERVHKRSAER-EVIIDQLP 573
            .||:.:|.... :|::|.    .|...|  :|...:|:.|.....|.|:.....:. :.|:|...
  Fly  2071 GVMDYNGDDHTLILMKDSHPMAKPRSLG--ILDHRLYYLDPLYERIVRIDLPHGDNPKTIVDNES 2133

Human   574 DLMGLKATNVHRVIGSNPCAEENGGCSHLCLYRPQGLR-CACPIGFELISDMKTCIVPEAFLLFS 637
            ||..:.... .|.:..:||...||||.|||:..|...| |||.||:...::: .|:..:.|.:.|
  Fly  2134 DLRSMMIYK-KRALMQHPCQTNNGGCKHLCIPGPGATRTCACGIGYRKENEI-NCVAYKIFAVVS 2196

Human   638 RRADIRRISLETNNNNVAIPLTGVKEASALDFDV--TDNRIYWTDIS---LKTISRAFMNGSALE 697
            :...||..|| ::::...:|::|... ..|..||  .:..|||.:.:   ...|.|:..||:.|:
  Fly  2197 QLDMIRGYSL-SDSSEAMVPISGPGH-HILHVDVMYREQWIYWAEYNRGYWNGIFRSRPNGTDLQ 2259

Human   698 HVVEFGL--DYPEGMAVDWLGKNLYWADT--GTNRIEVSKLDGQHRQVLVWKDLDSPRALALDPA 758
            |||:.|:  :...|:.:||:..|:|:.:.  ..|.:||..|||.:|:|||....|:||.||::|.
  Fly  2260 HVVKDGIGSNGIRGLTIDWVAGNMYFTNVYPHENYVEVCWLDGSNRKVLVKTTTDAPRELAVNPI 2324

Human   759 EGFMYWTEWGGKPKIDRAAMDGSERTTLVPN-VGRANGLTIDYAKRRLYWTDLDTNLIESSNMLG 822
            :..:||.::|..|:|.:|.:|||:.|.||.: :.....||||.....:||.|...:.|:..:..|
  Fly  2325 KRLLYWIDYGQHPRIGKALLDGSKWTPLVTSGISLPRDLTIDMQTHDIYWVDSKLDTIQKISYNG 2389

Human   823 LNREVIADDLPHPFGLTQYQDYIYWTDWSRRSIERANK-TSGQNRTIIQGHLDYVMDILVF--HS 884
            .||::|..|||:|.|:..|.:.:||.|.:..::.:|:| ::.:..|.::.:|:.:.||.::  ::
  Fly  2390 ANRKIIRRDLPNPMGIAVYLNDVYWVDRNLMTVFKASKHSANETATSVRTNLEKLRDIAIYNINN 2454

Human   885 SRQSGWNECAS-SNGHCSHLCLAVPVGG----------FVCGCPAHYSLNADNRTCSAPTTFLLF 938
            ..|...|.||. .||.|..||.:.|..|          |.|.| |...|:||.|.|.....:|:|
  Fly  2455 QPQDDTNPCAHLGNGGCDQLCFSFPPDGGASGTSGGRNFRCEC-ATGKLSADERKCEVVNEYLVF 2518

Human   939 SQKSAINRMVIDEQQSPDIILPIHSLRNVRAIDYDPLDKQLYWIDSR---QNMIRKAQEDGSQGF 1000
            :.::.|..:.:|...:.....|:.:|.||..:|:|....::.:...|   :....||.:.|....
  Fly  2519 ATRTEIRAVNLDPHSTEVPFTPLTNLTNVVGLDFDFAHNRMLYTQIRPWAKIAYTKANKPGHDDI 2583

Human  1001 TVVVSSVPSQNLEIQPYDLSIDIYSRYIYWTCEATNVINVTRLDGRSVGVVLKGEQDRPRAVVVN 1065
            |||:      |..|.|..::.|...:.||||..:.|.|....|||..:.::.:.|  ||||:|::
  Fly  2584 TVVL------NKGINPEGIAYDWTQQKIYWTDSSNNSIYAMNLDGSELVMIARVE--RPRAIVLD 2640

Human  1066 PEKGYMYFTNLQE--RSPKIERAALDGTEREVLFFSGLSKPIALALDSRLGKLFWADSDLRRIES 1128
            |..|.::||:...  .|.||.|..:.|:.:..:....||:|..||:|....:|:|.|:...:||.
  Fly  2641 PCNGTLFFTDWGRFGTSGKIFRTTMAGSLKRAIVDKDLSQPSGLAIDYDERRLYWTDAVREKIER 2705

Human  1129 SDLSEMAFCHVAQADVELLGSRDPPASASQITEITGANRIVLEDSNILQPVGLTVFENWLYWIDK 1193
            |||.                               |.||.:|..:.| .|..:|||.|::||.|.
  Fly  2706 SDLD-------------------------------GQNRELLVAATI-YPFAITVFRNYIYWTDL 2738

Human  1194 QQQMIEKIDMTGREGRTKVQARIAQLSDIHAVKELNL-----QEYRQHPCAQDNGGCSHICLVKG 1253
            |.:.:.:.:.  ..|...|: .:.:|.|  :.:::.:     |:...:||..:||||:..|....
  Fly  2739 QLRGVYRAEK--HTGANMVE-MVKRLED--SPRDIRIYSSDRQKCNVNPCRINNGGCAQSCHPAP 2798

Human  1254 DGTTRCSCPMHLVLLQDELSCG-EPPTCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDE--LN 1315
            :|...|.|.....::.:...|. ...||...:|.|..|.  ||...|.|||..:|.|:|||  ..
  Fly  2799 NGKAECKCDDSTKVVNEGRMCAPRNNTCEASKFYCKNGR--CISRMWSCDGDDDCGDNSDEDPNY 2861

Human  1316 CPV--CSESQFQCASGQCIDGALRCNGDANCQDKSDEKNCEV-LCLIDQFRCANGQCIGKHKKCD 1377
            |..  ||.::|:|.:|:||..:.:|:.:.:|:|.|||..|.. .|:..:|.||||:||.:.:.|:
  Fly  2862 CAYHSCSPNEFRCNNGRCIFKSWKCDHENDCKDGSDELGCVYPPCVDGEFTCANGRCIPQAQVCN 2926

Human  1378 HNVDCSDK--SDELDCYPTEEPAPQAT 1402
            ...||.|.  |||     |.|..|..|
  Fly  2927 GVNDCKDNATSDE-----THERCPMNT 2948

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LRP6NP_001401173.1 YncE 1..204 CDD:442618 79/186 (42%)
Beta-propeller 1 20..275 109/259 (42%)
LY 89..127 CDD:214531 17/37 (46%)
Ldl_recept_b 150..191 CDD:459654 27/42 (64%)
LY 175..216 CDD:214531 22/40 (55%)
LY 217..251 CDD:214531 17/35 (49%)
LDL-receptor class B 5 237..276 13/38 (34%)
FXa_inhibition 286..323 CDD:464251 17/37 (46%)
Beta-propeller 2 328..589 70/285 (25%)
LY 353..393 CDD:214531 10/44 (23%)
LY 397..437 CDD:214531 13/44 (30%)
Ldl_recept_b 458..499 CDD:459654 15/43 (35%)
LY 483..524 CDD:214531 11/40 (28%)
LY 525..558 CDD:214531 8/37 (22%)
FXa_inhibition 592..627 CDD:464251 15/35 (43%)
Beta-propeller 3 631..890 84/271 (31%)
YncE <654..813 CDD:442618 57/168 (34%)
LY 697..739 CDD:214531 15/45 (33%)
LY 827..866 CDD:214531 12/39 (31%)
FXa_inhibition 893..929 CDD:464251 17/46 (37%)
LY 958..998 CDD:214531 10/42 (24%)
YncE <968..1075 CDD:442618 31/109 (28%)
LY 1094..1132 CDD:214531 13/37 (35%)
FXa_inhibition 1238..1274 CDD:464251 9/35 (26%)
LDLa 1280..1316 CDD:238060 15/37 (41%)
LDLa 1319..1353 CDD:238060 13/33 (39%)
LDLa 1357..1391 CDD:238060 15/35 (43%)
PPPSP motif A 1518..1524
PPPSP motif B 1558..1565
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1587..1644
PPPSP motif C 1599..1606
PPPSP motif D 1619..1624
PPPSP motif E 1634..1641
mglNP_572563.3 LDLa 157..189 CDD:238060
LDLa 204..236 CDD:238060
LDLa 292..327 CDD:238060
LDLa 332..366 CDD:238060
LDLa 371..412 CDD:238060
vWFA <447..488 CDD:469594
YncE <492..634 CDD:442618
NHL 573..>716 CDD:302697
NHL repeat 573..610 CDD:271320
NHL repeat 616..654 CDD:271320
NHL repeat 657..693 CDD:271320
FXa_inhibition 763..805 CDD:464251
YvrE 854..>992 CDD:442613
LY 922..964 CDD:214531
LY 973..1007 CDD:214531
Ldl_recept_a 1188..1223 CDD:395011
LDLa 1227..1259 CDD:197566
LDLa 1268..1303 CDD:238060
LDLa 1308..1343 CDD:238060
LDLa 1356..1387 CDD:238060
LDLa 1391..1423 CDD:197566
LDLa 1435..1469 CDD:197566
FXa_inhibition 1522..1553 CDD:464251
LY 1625..1665 CDD:214531 19/39 (49%)
LY 1667..1711 CDD:214531 22/43 (51%)
Ldl_recept_b 1690..1729 CDD:459654 26/38 (68%)
LY 1712..1754 CDD:214531 22/41 (54%)
LY 1986..2037 CDD:214531 18/50 (36%)
FXa_inhibition 2151..>2179 CDD:464251 15/27 (56%)
LY 2259..2305 CDD:214531 15/45 (33%)
Ldl_recept_b 2326..2366 CDD:459654 14/39 (36%)
LY 2352..2392 CDD:214531 11/39 (28%)
NHL 2579..>2711 CDD:302697 46/170 (27%)
NHL repeat 2593..2622 CDD:271320 9/28 (32%)
NHL repeat 2634..2678 CDD:271320 13/43 (30%)
LY 2671..2713 CDD:214531 15/72 (21%)
LDLa 2867..2901 CDD:238060 13/33 (39%)
LDLa 2906..2941 CDD:238060 15/39 (38%)
LDLa 2950..2983 CDD:238060
LDLa 3034..3066 CDD:197566
LDLa 3080..3115 CDD:197566
LDLa 3128..3159 CDD:238060
LDLa 3170..3204 CDD:238060
LDLa 3210..3242 CDD:197566
FXa_inhibition 3259..3287 CDD:464251
FXa_inhibition 3293..3329 CDD:464251
LY 3362..3394 CDD:214531
LY 3406..3448 CDD:214531
Ldl_recept_b 3468..3511 CDD:459654
LY 3498..3536 CDD:214531
LY 3536..3578 CDD:214531
FXa_inhibition 3607..3659 CDD:464251
LDLa 3663..3696 CDD:238060
LDLa 3705..3739 CDD:238060
LDLa 3743..3775 CDD:197566
LDLa 3784..3817 CDD:197566
LDLa 3827..3861 CDD:197566
LDLa 3871..3901 CDD:197566
LDLa 3913..3947 CDD:238060
LDLa 3952..3986 CDD:238060
LDLa 3996..4027 CDD:197566
LDLa 4043..4071 CDD:238060
LDLa 4086..4117 CDD:238060
EGF_CA 4163..4194 CDD:214542
NHL 4276..>4426 CDD:302697
NHL repeat 4291..4336 CDD:271320
Ldl_recept_b 4350..4391 CDD:459654
LY 4374..4417 CDD:214531
NHL repeat 4376..4422 CDD:271320
Blue background indicates that the domain is not in the aligned region.

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