Sequence 1: | NP_002327.2 | Gene: | LRP6 / 4040 | HGNCID: | 6698 | Length: | 1613 | Species: | Homo sapiens |
---|---|---|---|---|---|---|---|---|---|
Sequence 2: | NP_524737.2 | Gene: | arr / 44279 | FlyBaseID: | FBgn0000119 | Length: | 1678 | Species: | Drosophila melanogaster |
Alignment Length: | 1658 | Identity: | 715/1658 - (43%) |
---|---|---|---|
Similarity: | 997/1658 - (60%) | Gaps: | 139/1658 - (8%) |
- Green bases have known domain annotations that are detailed below.
Human 23 LLYANRRDLRLVDAT--NGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKRTEFNKT-- 83
Human 84 -----ESVQNVVVSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQPRAI 143
Human 144 ALDPSSGFMYWTDWGEVPKIERAGMDGS--SRFIIINSEIYWPNGLTLDYEEQKLYWADAKLNFI 206
Human 207 HKSNLDGTNRQAVVKGSLPHPFALTLFEDILYWTDWSTHSILACNKYTGEGLREIHSDIFSPMDI 271
Human 272 HAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLENGKTCKDGATELLLLARR 336
Human 337 TDLRRISLDTPDFTDIVLQLEDIRHAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQ 401
Human 402 IAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRAIVLDPMVGYMYWTDWG 466
Human 467 E-IPKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEVMNTDGTGRRVLVED 530
Human 531 KIPHIFGFTLLGDYVYWTDWQRRSIERVHKRSA-EREVIIDQLPDLMGLKATNVHRVIGSNPCAE 594
Human 595 ENGGCSHLCLYRPQGLRCACPIGFELISDMKTCIVPEAFLLFSRRADIRRISL---ETNNNNVAI 656
Human 657 PLTGVKEASALDFDVTDNRIYWTDISLKTISRAFMNGSALEHVVEFGLDYPEGMAVDWLGKNLYW 721
Human 722 ADTGTNRIEVSKLDGQHRQVLVWKDLDSPRALALDPAEGFMYWTEWGGKPKIDRAAMDGSERTTL 786
Human 787 VPNVGRANGLTIDYAKRRLYW-TDLDTNLIESSNMLGLNREV-IADDLPHPFGLTQYQDYIYWTD 849
Human 850 WSRRSIERANKTSGQNRTIIQGHLDYVMDILVFHSSRQSGWNECASSNGHCSHLCLAVPVG--GF 912
Human 913 VCGCPAHYSLNADNRTCSAPTTFLLFSQKSAINRMVIDEQQSPDIILPIHSLRNVRAIDYDPLDK 977
Human 978 QLYWIDSRQNMIRKAQEDGSQGFTVVVSSVPSQNLEIQPYDLSIDIYSRYIYWTCEATNVINVTR 1042
Human 1043 LDGRSVGVVLKGEQDRPRAVVVNPEKGYMYFTNLQERSPKIERAALDGTEREVLFFSGLSKPIAL 1107
Human 1108 ALDSRLGKLFWADSDLRRIESSDLSGANRIVLEDSNILQPVGLTVFENWLYWIDKQQQMIEKIDM 1172
Human 1173 TGREGRTKVQARIAQLSDIHAVKELNLQEYRQHPCAQDNGGCSHICLVKGDGTTR----CSCPMH 1233
Human 1234 LVLLQDELSCGEPPTCSPQQFTC---FTG----EIDCIPVAWRCDGFTECEDHSDELNCPVCSES 1291
Human 1292 QFQCASGQCIDGALRCNGDANCQDKSDEKNCEVLC-LIDQFRC-ANGQCIGKHKKCDHNVDCSDK 1354
Human 1355 SDELDCYPTEEPAPQATNTVGSVI---GVIVTIFVSGTVYFICQRMLCPRMKGDGETMTNDYVVH 1416
Human 1417 GPASVPLGYVPHPSSLSGSLPGMSRGKSMISSL-------SIMGGSSGPPYDRAHVTGASSSSSS 1474
Human 1475 STKGTYFPAILNPPPSPATERSHYTMEFGYSSNSPSTHRSYSYRPYSYRHF-----APPTTPCST 1534
Human 1535 DVC---DSDY------------APSRRMTSVATAKGYTSDLNYDSEPVPPPPTPRSQYLS----A 1580
Human 1581 EENYESCPPSPYTERSYSHHLYPPPPSPCTDSS 1613 |
Gene | Sequence | Domain | Region | External ID | Identity |
---|---|---|---|---|---|
LRP6 | NP_002327.2 | Beta-propeller 1 | 20..275 | 109/262 (42%) | |
NHL | 55..272 | CDD:302697 | 99/225 (44%) | ||
NHL repeat | 55..93 | CDD:271320 | 11/44 (25%) | ||
LY | 89..127 | CDD:214531 | 22/37 (59%) | ||
NHL repeat | 97..132 | CDD:271320 | 21/34 (62%) | ||
NHL repeat | 140..176 | CDD:271320 | 22/37 (59%) | ||
Ldl_recept_b | 150..190 | CDD:278487 | 22/41 (54%) | ||
LY | 175..216 | CDD:214531 | 15/40 (38%) | ||
NHL repeat | 181..217 | CDD:271320 | 15/35 (43%) | ||
NHL repeat | 226..253 | CDD:271320 | 13/26 (50%) | ||
LDL-receptor class B 5 | 237..276 | 14/38 (37%) | |||
FXa_inhibition | 286..323 | CDD:291342 | 18/36 (50%) | ||
Beta-propeller 2 | 328..589 | 153/262 (58%) | |||
LY | 353..393 | CDD:214531 | 21/39 (54%) | ||
LY | 397..437 | CDD:214531 | 28/39 (72%) | ||
LY | 438..481 | CDD:214531 | 27/43 (63%) | ||
LY | 483..524 | CDD:214531 | 26/40 (65%) | ||
LY | 525..558 | CDD:214531 | 19/32 (59%) | ||
FXa_inhibition | 592..627 | CDD:291342 | 19/34 (56%) | ||
Beta-propeller 3 | 631..890 | 124/263 (47%) | |||
LY | 656..694 | CDD:214531 | 20/37 (54%) | ||
LY | 697..739 | CDD:214531 | 21/41 (51%) | ||
LY | 740..783 | CDD:214531 | 23/42 (55%) | ||
LY | 783..825 | CDD:214531 | 17/42 (40%) | ||
LY | 827..866 | CDD:214531 | 17/39 (44%) | ||
FXa_inhibition | 893..929 | CDD:291342 | 20/37 (54%) | ||
Beta-propeller 4 | 933..1202 | 87/268 (32%) | |||
LY | 958..998 | CDD:214531 | 16/39 (41%) | ||
Ldl_recept_b | 1069..1110 | CDD:278487 | 13/40 (33%) | ||
LY | 1094..1136 | CDD:214531 | 12/41 (29%) | ||
FXa_inhibition | 1207..1243 | CDD:291342 | 18/39 (46%) | ||
LDLa | 1249..1285 | CDD:238060 | 20/42 (48%) | ||
LDLa | 1288..1322 | CDD:238060 | 16/33 (48%) | ||
LDLa | 1326..1360 | CDD:238060 | 12/35 (34%) | ||
PPPSP motif A | 1487..1493 | 5/5 (100%) | |||
PPPSP motif B | 1527..1534 | 5/6 (83%) | |||
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1556..1613 | 30/60 (50%) | |||
PPPSP motif C | 1568..1575 | 6/6 (100%) | |||
PPPSP motif D | 1588..1593 | 4/4 (100%) | |||
PPPSP motif E | 1603..1610 | 6/6 (100%) | |||
arr | NP_524737.2 | LY | 162..201 | CDD:214531 | 22/38 (58%) |
NHL | 168..503 | CDD:302697 | 168/337 (50%) | ||
NHL repeat | 172..237 | CDD:271320 | 39/64 (61%) | ||
LY | 252..293 | CDD:214531 | 15/40 (38%) | ||
NHL repeat | 261..298 | CDD:271320 | 16/37 (43%) | ||
NHL repeat | 303..339 | CDD:271320 | 17/36 (47%) | ||
NHL repeat | 341..419 | CDD:271320 | 32/78 (41%) | ||
NHL repeat | 428..476 | CDD:271320 | 24/47 (51%) | ||
LY | 472..511 | CDD:214531 | 28/38 (74%) | ||
NHL repeat | 477..503 | CDD:271320 | 20/25 (80%) | ||
Ldl_recept_b | 534..573 | CDD:278487 | 26/38 (68%) | ||
LY | 558..599 | CDD:214531 | 26/40 (65%) | ||
LY | 600..641 | CDD:214531 | 22/40 (55%) | ||
FXa_inhibition | 668..703 | CDD:291342 | 19/34 (56%) | ||
LY | 739..773 | CDD:214531 | 18/33 (55%) | ||
LY | 776..818 | CDD:214531 | 21/41 (51%) | ||
LY | 819..860 | CDD:214531 | 22/41 (54%) | ||
FXa_inhibition | 973..1010 | CDD:291342 | 20/37 (54%) | ||
LY | 1122..1164 | CDD:214531 | 12/42 (29%) | ||
FXa_inhibition | 1273..1313 | CDD:291342 | 18/39 (46%) | ||
LDLa | 1319..1362 | CDD:238060 | 20/42 (48%) | ||
LDLa | 1365..1399 | CDD:238060 | 16/33 (48%) | ||
LDLa | 1399..1433 | CDD:197566 | 11/36 (31%) |
Tool | Simple Score | Weighted Score | Original Tool Information | |||
---|---|---|---|---|---|---|
BLAST Result | Score | Score Type | Cluster ID | |||
Compara | 1 | 0.930 | - | - | C165155343 | |
Domainoid | 1 | 1.000 | 124 | 1.000 | Domainoid score | I5536 |
eggNOG | 1 | 0.900 | - | - | E1_KOG1215 | |
Hieranoid | 1 | 1.000 | - | - | ||
Homologene | 1 | 1.000 | - | - | H1747 | |
Inparanoid | 1 | 1.050 | 1329 | 1.000 | Inparanoid score | I146 |
Isobase | 1 | 0.950 | - | 0 | Normalized mean entropy | S5302 |
OMA | 1 | 1.010 | - | - | QHG48457 | |
OrthoDB | 1 | 1.010 | - | - | D121310at2759 | |
OrthoFinder | 1 | 1.000 | - | - | FOG0004181 | |
OrthoInspector | 1 | 1.000 | - | - | otm42137 | |
orthoMCL | 1 | 0.900 | - | - | OOG6_100345 | |
Panther | 0 | 0.000 | Not matched by this tool. | |||
Phylome | 1 | 0.910 | - | - | ||
RoundUp | 0 | 0.000 | Not matched by this tool. | |||
SonicParanoid | 1 | 1.000 | - | - | X3498 | |
SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
TreeFam | 1 | 0.960 | - | - | ||
User_Submission | 0 | 0.000 | Not matched by this tool. | |||
15 | 14.620 |