DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment LRP6 and arr

DIOPT Version :10

Sequence 1:NP_001401173.1 Gene:LRP6 / 4040 HGNCID:6698 Length:1644 Species:Homo sapiens
Sequence 2:NP_524737.2 Gene:arr / 44279 FlyBaseID:FBgn0000119 Length:1678 Species:Drosophila melanogaster


Alignment Length:1689 Identity:716/1689 - (42%)
Similarity:996/1689 - (58%) Gaps:170/1689 - (10%)


- Green bases have known domain annotations that are detailed below.


Human    23 LLYANRRDLRLVDAT--NGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKRTEFNKT-- 83
            ||:..|.|:::.:.|  .|.....::|..|.:|.|:||.::..|:.|:|...|.|:..:.|.:  
  Fly    89 LLFTTRHDIQVANITRPTGGPQIDVIVRDLAEAMAIDFYYAKNLVCWTDSGREIIECAQTNSSAL 153

Human    84 -----ESVQNVVVSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQPRAI 143
                 ...|.|:.:||..|:|||.||..:|:||||.|.|||||:.|||..:|||||.:||||||:
  Fly   154 QPLLRAPKQTVISTGLDKPEGLAMDWYTDKIYWTDGEKNRIEVATLDGRYQKVLFWTDLDQPRAV 218

Human   144 ALDPSSGFMYWTDWGEVPKIERAGMDGS--SRFIIINSEIYWPNGLTLDYEEQKLYWADAKLNFI 206
            |:.|:...:.||||||.||||||.|||.  ||..::...::|||||.:|.:.:.:||.|.|.:||
  Fly   219 AVVPARKLLIWTDWGEYPKIERASMDGDPLSRMTLVKEHVFWPNGLAVDLKNELIYWTDGKHHFI 283

Human   207 HKSNLDGTNRQAVVKGSLPHPFALTLFEDILYWTDWSTHSILACNKYTGEGLREIHSDIFSPMDI 271
            ....|||::|:.:| .:|.:||:||.::|.||||||...|:.|.:..|.| |:|:.....:|..:
  Fly   284 DVMRLDGSSRRTIV-NNLKYPFSLTFYDDRLYWTDWQRGSLNALDLQTRE-LKELIDTPKAPNSV 346

Human   272 HAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLENGKTCKDGATELLLLARR 336
            .|:....||...|||..:||.||||||::.....:.|||||||||: :..||.:|:.|::.:.:|
  Fly   347 RAWDPSLQPYEDNPCAHNNGNCSHLCLLATNSQGFSCACPTGVKLI-SANTCANGSQEMMFIVQR 410

Human   337 TDLRRISLDTPDFTDIVLQLEDIRHAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQ 401
            |.:.:||||:||:|...|.|..:::||||||||||.:|||:|.|...|:|:..||:|....||::
  Fly   411 TQISKISLDSPDYTIFPLPLGKVKYAIAIDYDPVEEHIYWSDVETYTIKRAHADGTGVTDFVTSE 475

Human   402 IAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRAIVLDPMVGYMYWTDWG 466
            :.||||:|:||:|||||||||.||||||.||:||.||:||.|.|||||||.:.|.:|:|:|:||.
  Fly   476 VRHPDGLALDWLARNLYWTDTVTDRIEVCRLDGTARKVLIYEHLEEPRAIAVAPSLGWMFWSDWN 540

Human   467 E-IPKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEVMNTDGTGRRVLVED 530
            | .||:|||:||||:|||||:.:||||||:|||.:...|||.|.|||||||.|.||:||||::.|
  Fly   541 ERKPKVERASLDGSERVVLVSENLGWPNGIALDIEAKAIYWCDGKTDKIEVANMDGSGRRVVISD 605

Human   531 KIPHIFGFTLLGDYVYWTDWQRRSIERVHKRSA-EREVIIDQLPDLMGLKATNVHRVIGSNPCAE 594
            .:.|:||.::|.||:||||||||||:|.||.:. .|.|::||.|||||||.|.:..|.|.|.||.
  Fly   606 NLKHLFGLSILDDYLYWTDWQRRSIDRAHKITGNNRIVVVDQYPDLMGLKVTRLREVRGQNACAV 670

Human   595 ENGGCSHLCLYRPQGLRCACPIGFELISDMKTCIVPEAFLLFSRRADIRRISL---ETNNNNVAI 656
            .|||||||||.||:...|.|.|.:||.:|.:||:||.|||||||:..|.|||:   |.|:|:..|
  Fly   671 RNGGCSHLCLNRPRDYVCRCAIDYELANDKRTCVVPAAFLLFSRQEHIGRISIEYNEGNHNDERI 735

Human   657 PLTGVKEASALDFDVTDNRIYWTDISLKTISRAFMNGSALEHVVEFGLDYPEGMAVDWLGKNLYW 721
            |...|::|.|||..|.:.||||||...|.|.|||:|||.::.:|:.||..|:|:|||||..|:||
  Fly   736 PFKDVRDAHALDVSVAERRIYWTDQKSKCIFRAFLNGSYVQRIVDSGLIGPDGIAVDWLANNIYW 800

Human   722 ADTGTNRIEVSKLDGQHRQVLVWKDLDSPRALALDPAEGFMYWTEWGGKPKIDRAAMDGSERTTL 786
            :|....||||::|||..|:||:||.::.||:|.|:|..|:||||| .....|.|||||||:..|:
  Fly   801 SDAEARRIEVARLDGSSRRVLLWKGVEEPRSLVLEPRRGYMYWTE-SPTDSIRRAAMDGSDLQTI 864

Human   787 VPNVGRANGLTIDYAKRRLYW-TDLDTNLIESSNMLGLNREV-IADDLPHPFGLTQYQDYIYWTD 849
            |.....|.|||.|...||||| |......|||::..|..|:: :..|:..|:.::.||||:||:|
  Fly   865 VAGANHAAGLTFDQETRRLYWATQSRPAKIESADWDGKKRQILVGSDMDEPYAVSLYQDYVYWSD 929

Human   850 WSRRSIERANKTSGQNRTIIQGHLDYVMDILVFHSSRQSGWNECASSNGHCSHLCLAVPVG--GF 912
            |:...|||.:||:||||:::...:.|:..:|||:..||:|.|.|..:||.|||||||.| |  |.
  Fly   930 WNTGDIERVHKTTGQNRSLVHSGMTYITSLLVFNDKRQTGVNPCKVNNGGCSHLCLAQP-GRRGM 993

Human   913 VCGCPAHYSLNADNRTCSAPTTFLLFSQKSAINRMVIDEQQSPDIILPIHSLRNVRAIDYDPLDK 977
            .|.||.||.|..|..:|..|..:::|||::...|::.:....|:|.||: |.:|:||:||||:..
  Fly   994 TCACPTHYQLAKDGVSCIPPRNYIIFSQRNCFGRLLPNTTDCPNIPLPV-SGKNIRAVDYDPITH 1057

Human   978 QLYWIDSRQNMIRKAQEDGSQGFTVVVSSVPSQNLEIQPYDLSIDIYSRYIYWTCEATNVINVTR 1042
            .:|||:.|.:.|:::..:|::     ||.:.:..   ||:||:|||..|.::|||..:|.||||.
  Fly  1058 HIYWIEGRSHSIKRSLANGTK-----VSLLANSG---QPFDLAIDIIGRLLFWTCSQSNSINVTS 1114

Human  1043 LDGRSVGVVLKGEQDRPRAVVVNPEKGYMYFTNLQERSPKIERAALDGTEREVLFFSGLSKPIAL 1107
            ..|.||||:..|:.::||.:.|:..|..:::|::.... .|.||.:||.||..|.:. |....||
  Fly  1115 FLGESVGVIDTGDSEKPRNIAVHAMKRLLFWTDVGSHQ-AIIRARVDGNERVELAYK-LEGVTAL 1177

Human  1108 ALDSRLGKLFWADSDLRRIESSDLSEMAFCHVAQADVELLGSRDPPASASQITEITGANRIVLED 1172
            |||.:...:::|..  :||::.|                               |.|.|:..|..
  Fly  1178 ALDQQSDMIYYAHG--KRIDAID-------------------------------INGKNKKTLVS 1209

Human  1173 SNILQPVGLTVFENWLYWIDKQQQMIEKIDMTGREGRTKVQARIAQLSDIHAVKELNLQEYRQHP 1237
            .:|.|.:.:.....::||:| .:..:|:|.:.|.....::| |:.|::||.||...:.:..|.|.
  Fly  1210 MHISQVINIAALGGFVYWLD-DKTGVERITVNGERRSAELQ-RLPQITDIRAVWTPDPKVLRNHT 1272

Human  1238 CAQDNGGCSHICLVKGDGTTR----CSCPMHLVLLQDELSCGEPPTCSPQQFTC---FTG----E 1291
            |......|||||:..|:|..|    ||||.||:||:|:.:||..|.|.|..|||   .:|    .
  Fly  1273 CMHSRTKCSHICIASGEGIARTRDVCSCPKHLMLLEDKENCGAFPACGPDHFTCAAPVSGISDVN 1337

Human  1292 IDCIPVAWRCDGFTECEDHSDELNCPVCSESQFQCASGQCIDGALRCNGDANCQDKSDEKNCEVL 1356
            .||||.:|||||..:|.|.|||:.||.|...||.|.||:|||.:|.|:|..||.:..||.:|   
  Fly  1338 KDCIPASWRCDGQKDCPDKSDEVGCPTCRADQFSCQSGECIDKSLVCDGTTNCANGHDEADC--- 1399

Human  1357 C-LIDQFRC-ANGQCIGKHKKCDHNVDCSDKSDELDCYPTEEPAPQATNTVGSVI---GVIVTIF 1416
            | ...:|:| .|..||.....||...:|:|.:||......:.....||:....:|   ..::|||
  Fly  1400 CKRPGEFQCPINKLCISAALLCDGWENCADGADESSDICLQRRMAPATDKRAFMILIGATMITIF 1464

Human  1417 VSGTVYFICQRMLCPRMKGDGETMTNDYVVHGPASVPLGYVPHPSSLSGSLPGMSRGKSMISSL- 1480
              ..||.:   ..|....|...|...|.....|.|        ||:||     .|:..|.|:|: 
  Fly  1465 --SIVYLL---QFCRTRIGKSRTEPKDDQATDPLS--------PSTLS-----KSQRVSKIASVA 1511

Human  1481 ------SIMGGSSGPPYDRAHVTGASSSSSSSTKGTYFPAILNPPPSPATERSHYTMEFGYSSNS 1539
                  ::...:|...|||.|:||||||:::.:....:|  :||||||||.              
  Fly  1512 DAVRMSTLNSRNSMNSYDRNHITGASSSTTNGSSMVAYP--INPPPSPATR-------------- 1560

Human  1540 PSTHRSYSYRPYSYRHF-----APPTTPCSTDVC---DSDY------------APSRRMTSVATA 1584
                   |.||  |||:     .||.||||||:|   ||:|            |.....:|.|..
  Fly  1561 -------SRRP--YRHYKIINQPPPPTPCSTDICDESDSNYTSKSNSNNSNGGATKHSSSSAAAC 1616

Human  1585 KGYTSDLNYDSEPVPPPPTPRSQYLS----AEENYESCPPSPYTERSYSHHLYPPPPSPCTDSS 1644
            ..|    .|||||.||||||||.|.|    ..|:  ||||||.:..|......||||||....|
  Fly  1617 LQY----GYDSEPYPPPPTPRSHYHSDVRIVPES--SCPPSPSSRSSTYFSPLPPPPSPVQSPS 1674

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LRP6NP_001401173.1 YncE 1..204 CDD:442618 82/191 (43%)
Beta-propeller 1 20..275 109/262 (42%)
LY 89..127 CDD:214531 22/37 (59%)
Ldl_recept_b 150..191 CDD:459654 22/42 (52%)
LY 175..216 CDD:214531 15/40 (38%)
LY 217..251 CDD:214531 15/33 (45%)
LDL-receptor class B 5 237..276 14/38 (37%)
FXa_inhibition 286..323 CDD:464251 18/36 (50%)
Beta-propeller 2 328..589 153/262 (58%)
LY 353..393 CDD:214531 21/39 (54%)
LY 397..437 CDD:214531 28/39 (72%)
Ldl_recept_b 458..499 CDD:459654 28/41 (68%)
LY 483..524 CDD:214531 26/40 (65%)
LY 525..558 CDD:214531 19/32 (59%)
FXa_inhibition 592..627 CDD:464251 19/34 (56%)
Beta-propeller 3 631..890 124/263 (47%)
YncE <654..813 CDD:442618 80/159 (50%)
LY 697..739 CDD:214531 21/41 (51%)
LY 827..866 CDD:214531 17/39 (44%)
FXa_inhibition 893..929 CDD:464251 20/37 (54%)
LY 958..998 CDD:214531 16/39 (41%)
YncE <968..1075 CDD:442618 40/106 (38%)
LY 1094..1132 CDD:214531 11/37 (30%)
FXa_inhibition 1238..1274 CDD:464251 18/39 (46%)
LDLa 1280..1316 CDD:238060 20/42 (48%)
LDLa 1319..1353 CDD:238060 16/33 (48%)
LDLa 1357..1391 CDD:238060 12/35 (34%)
PPPSP motif A 1518..1524 5/5 (100%)
PPPSP motif B 1558..1565 5/6 (83%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1587..1644 30/60 (50%)
PPPSP motif C 1599..1606 6/6 (100%)
PPPSP motif D 1619..1624 4/4 (100%)
PPPSP motif E 1634..1641 6/6 (100%)
arrNP_524737.2 LY 162..201 CDD:214531 22/38 (58%)
NHL 168..503 CDD:302697 168/337 (50%)
NHL repeat 172..237 CDD:271320 39/64 (61%)
LY 252..293 CDD:214531 15/40 (38%)
NHL repeat 261..298 CDD:271320 16/37 (43%)
NHL repeat 303..339 CDD:271320 17/36 (47%)
NHL repeat 341..419 CDD:271320 32/78 (41%)
NHL repeat 428..476 CDD:271320 24/47 (51%)
LY 472..511 CDD:214531 28/38 (74%)
NHL repeat 477..503 CDD:271320 20/25 (80%)
Ldl_recept_b 534..574 CDD:459654 27/39 (69%)
LY 558..599 CDD:214531 26/40 (65%)
LY 600..641 CDD:214531 22/40 (55%)
FXa_inhibition 668..703 CDD:464251 19/34 (56%)
YncE <736..886 CDD:442618 77/150 (51%)
LY 776..818 CDD:214531 21/41 (51%)
LY 905..946 CDD:214531 17/40 (43%)
FXa_inhibition 973..1010 CDD:464251 20/37 (54%)
YncE <1047..1191 CDD:442618 56/153 (37%)
LDLa 1319..1362 CDD:238060 20/42 (48%)
LDLa 1365..1399 CDD:238060 16/33 (48%)
LDLa 1399..1433 CDD:197566 11/36 (31%)

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