DRSC/TRiP Functional Genomics Resources

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Protein Alignment LRP6 and LpR2

DIOPT Version :10

Sequence 1:NP_001401173.1 Gene:LRP6 / 4040 HGNCID:6698 Length:1644 Species:Homo sapiens
Sequence 2:NP_001097928.1 Gene:LpR2 / 43105 FlyBaseID:FBgn0051092 Length:1064 Species:Drosophila melanogaster


Alignment Length:309 Identity:132/309 - (42%)
Similarity:187/309 - (60%) Gaps:10/309 - (3%)


- Green bases have known domain annotations that are detailed below.


Human    23 LLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKRTEFNKTESVQ 87
            ||.|.|.|:|.:  ...:...|.:|...:.|.|:||||..|:|:||||:.::|.:...::.....
  Fly   612 LLLARRHDIRKI--ALDRPEMTSIVNSTKAATALDFVFRTGMIFWSDVATQSIYKAPIDEGNDRT 674

Human    88 NVVVSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQPRAIALDPSSGFM 152
            .|:....::.||||.||:...:|:||:....||::|.:||:.|||....||.||:|||||..|:|
  Fly   675 VVLTKSSVTSDGLAVDWIYNHVYFTDTHKCTIELTNFEGSMGKVLVKDSLDIPRSIALDPIEGWM 739

Human   153 YWTDWGEVPKIERAGMDGSSRFIIINSEIYWPNGLTLDYEEQKLYWADAKLNFIHKSNLDGTNRQ 217
            ||:|||..|:||||||||:.|..||..::.||||:|||..:::|||.|.|||.|..||.||:.|.
  Fly   740 YWSDWGASPRIERAGMDGTHRTAIITYDVKWPNGITLDLVQKRLYWVDGKLNTISSSNYDGSQRH 804

Human   218 AVVKGS--LPHPFALTLFEDILYWTDWSTHSILACNKYTGEGLREIHSD--IFSPMDIHAFSQQR 278
            .|:...  |.|||::|.|||.:|||||...::...||:.|..:..:.:.  :..||.:|.:...|
  Fly   805 QVLYSGEYLRHPFSITTFEDYVYWTDWDKQAVFKANKFNGMDVEPVTATHMLEHPMVVHVYHPYR 869

Human   279 QPNATNPCGIDNGGCSHLCLMSP----VKPFYQCACPTGVKLLENGKTC 323
            ||:..|.|...||.||||||.:|    ..|...||||||:||:.:|..|
  Fly   870 QPDGVNHCQSVNGHCSHLCLPAPRINERSPRISCACPTGLKLMPDGLMC 918

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LRP6NP_001401173.1 YncE 1..204 CDD:442618 79/180 (44%)
Beta-propeller 1 20..275 107/255 (42%)
LY 89..127 CDD:214531 13/37 (35%)
Ldl_recept_b 150..191 CDD:459654 25/40 (63%)
LY 175..216 CDD:214531 21/40 (53%)
LY 217..251 CDD:214531 14/35 (40%)
LDL-receptor class B 5 237..276 11/40 (28%)
FXa_inhibition 286..323 CDD:464251 20/40 (50%)
Beta-propeller 2 328..589
LY 353..393 CDD:214531
LY 397..437 CDD:214531
Ldl_recept_b 458..499 CDD:459654
LY 483..524 CDD:214531
LY 525..558 CDD:214531
FXa_inhibition 592..627 CDD:464251
Beta-propeller 3 631..890
YncE <654..813 CDD:442618
LY 697..739 CDD:214531
LY 827..866 CDD:214531
FXa_inhibition 893..929 CDD:464251
LY 958..998 CDD:214531
YncE <968..1075 CDD:442618
LY 1094..1132 CDD:214531
FXa_inhibition 1238..1274 CDD:464251
LDLa 1280..1316 CDD:238060
LDLa 1319..1353 CDD:238060
LDLa 1357..1391 CDD:238060
PPPSP motif A 1518..1524
PPPSP motif B 1558..1565
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1587..1644
PPPSP motif C 1599..1606
PPPSP motif D 1619..1624
PPPSP motif E 1634..1641
LpR2NP_001097928.1 LDLa 193..224 CDD:197566
LDLa 235..267 CDD:197566
LDLa 277..313 CDD:238060
LDLa 356..388 CDD:197566
LDLa 400..432 CDD:197566
LDLa 442..476 CDD:238060
LDLa 484..517 CDD:197566
FXa_inhibition 527..562 CDD:464251
EGF_CA 564..594 CDD:214542
LY 675..715 CDD:214531 14/39 (36%)
LY 717..760 CDD:214531 28/42 (67%)
LY 763..803 CDD:214531 21/39 (54%)
Ldl_recept_b 782..828 CDD:459654 22/45 (49%)
Ldl_recept_b 824..866 CDD:459654 12/41 (29%)
FXa_inhibition 877..918 CDD:464251 20/40 (50%)
Blue background indicates that the domain is not in the aligned region.

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