DRSC/TRiP Functional Genomics Resources

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Protein Alignment LRP6 and Culd

DIOPT Version :10

Sequence 1:NP_001401173.1 Gene:LRP6 / 4040 HGNCID:6698 Length:1644 Species:Homo sapiens
Sequence 2:NP_729364.1 Gene:Culd / 38946 FlyBaseID:FBgn0035880 Length:965 Species:Drosophila melanogaster


Alignment Length:970 Identity:190/970 - (19%)
Similarity:268/970 - (27%) Gaps:411/970 - (42%)


- Green bases have known domain annotations that are detailed below.


Human   839 TQYQDYIYWTDW-SRRSIERANKTSGQNRTIIQGHLDYVMDILVFHSSRQSG--WNECASSNGHC 900
            :.|:|......| .||........:|:..........|....|||.:...:|  |.:|:.....|
  Fly    30 SSYRDLDICNHWDGRRHFLELGSPAGEVHARNVTTTAYRSSPLVFKNDAVAGDVWYQCSLELVTC 94

Human   901 SHLCLAVP------------VGG--FVCGC-------PAHYSLNADNRTCSAPTTF--------L 936
            :...:.|.            .||  .:|.|       |.:.|..:....|.....|        |
  Fly    95 AECVIRVAFTYANFSKSCGNTGGKSSMCPCEHIQFSEPPYDSTISGQEFCGDGKVFRSKTRTLQL 159

Human   937 LFSQKSAINRMVIDEQQSPDIILPIHSLRNVRAIDYDPLDKQLYWIDSRQNMIRKAQEDGSQGFT 1001
            .|..: |.|..|..        |...|.||||.:...|          :|:::    .:||....
  Fly   160 KFFYR-ASNAHVFS--------LQYFSERNVRIVSGSP----------KQSIV----GNGSTKSQ 201

Human  1002 VVVSSVPSQNLEIQPYDLSIDIYSRYIYWTCEATNVINVTRLDGR--------------SVGVVL 1052
            ..|.|.|...: ..|.|..|:    :|. ||||.|.  ..|||..              |.|.:|
  Fly   202 PQVISTPYFPM-AYPRDYGIE----HIL-TCEADNC--QVRLDFTDFQLGLTSTLEIFDSNGQML 258

Human  1053 ---KGEQDRPRAVVVNPEKGYMYFTNLQERSPKIERAALDGTEREVLFFSGLSKPIALALDSRLG 1114
               .||..|| .:.|:..|..:    ||.|.   ..|...|...||.|.|  ||.:         
  Fly   259 DSYTGEHFRP-PITVSSGKSLL----LQFRG---NSATGVGFRAEVSFVS--SKQL--------- 304

Human  1115 KLFWADSDLRRIESSDLSEMAFCHVAQADVELLGSRDPPASASQITEITGANRIVLEDSNILQPV 1179
                  .|.|.:..:|...|.              ..|..:.:.:..|..|..:.|.|       
  Fly   305 ------KDERLVPYTDCGGMV--------------TGPGGAITMMNMIENATDVRLFD------- 342

Human  1180 GLTVFENWLYWIDK--QQQMIEKIDMTGREGRTKVQARIAQLSDIHAVKELNLQEYRQHPCAQDN 1242
                    ..||.|  ...|:.|         |.:..|:.....:.|..||.:::          
  Fly   343 --------CIWIIKPGNNYMMMK---------THISLRVDDFYGMAARSELTIRQ---------- 380

Human  1243 GGCSHICLVKGDGTTRCSCPMHLVLLQDELSCGEPPTCSPQQFTCFTGEIDCIPVAWRCDGFTEC 1307
                        |||                               :..::...|.|..:|.:: 
  Fly   381 ------------GTT-------------------------------SDAVEIENVMWPNNGLSK- 401

Human  1308 EDH----------------------------SDELNCPVCSESQFQCASGQCIDGALRCNGDANC 1344
            |.|                            .:.|||.:.||  |.|.:..||...|.|:|..:|
  Fly   402 ESHVAPILNGYYIRLRGVFGMSSKLAIVYSVFNYLNCYIGSE--FLCGNNHCISIRLHCDGFDHC 464

Human  1345 QDKSDE-KNCE-------------------VLCLIDQF---RCANGQCI---------------- 1370
            .|.||| .:||                   ....|||:   :.|.|..|                
  Fly   465 GDGSDEPDSCEEDWAHLHHDRRWYSHKPNYYFPKIDQYPDLKTATGIFIISTLGIFGVLSGWMVI 529

Human  1371 -------GKHKK--CDHNVDCS---DKSDELDCYPTEEP-------------------------- 1397
                   .:|::  ..|....|   |:.|| |..|.|.|                          
  Fly   530 LYRMGVRARHQRELQSHLQTISELLDRQDE-DRTPDEPPSYEAPPDYEEVIKVGMQQELREPRRQ 593

Human  1398 -----AP--------QATN-TVGSVI------------------GVIVTIFVSGT--------VY 1422
                 ||        .|:| ||.||:                  ...:|..|:.|        |.
  Fly   594 RRARRAPPRDRSCSRAASNCTVQSVLPLHRSCTLERDQEQPSTSAAAMTHAVAATDTTEDAEHVQ 658

Human  1423 FICQRML-----C-------PRMKGDGETMTNDYVVHGPASVPLGYVPHPSSLS--GSLPGMSRG 1473
            .:.||||     |       |..|..|:.:.:           :|....|||||  |.||     
  Fly   659 TMAQRMLLATAICGTAGTSLPAAKESGQRVQS-----------VGISTSPSSLSAGGELP----- 707

Human  1474 KSMISSLSIMGGSSGPPYDRAH--VTGASSSSSSSTKGTYFPAILNPPPSPATERSHYTMEFGYS 1536
                    ..|||:..|...|.  ..|..|.|.|.|.|.         ||...|....|.:....
  Fly   708 --------TAGGSATTPGSTADECTQGGDSLSISLTLGL---------PSTTAESPVTTDQNQLQ 755

Human  1537 SNSPS------THRSYSYRPYSYRHFAPPTTPCSTDVCDSDYAPSRRMTSVATAKGYTSD 1590
            ..||.      |..::..|.:......||         ...|...|...:.::.:.:|||
  Fly   756 KQSPEQTISNCTEHTFLKRSWLVVQQVPP---------GRGYRVRRLRHTFSSPEAFTSD 806

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LRP6NP_001401173.1 YncE 1..204 CDD:442618
Beta-propeller 1 20..275
LY 89..127 CDD:214531
Ldl_recept_b 150..191 CDD:459654
LY 175..216 CDD:214531
LY 217..251 CDD:214531
LDL-receptor class B 5 237..276
FXa_inhibition 286..323 CDD:464251
Beta-propeller 2 328..589
LY 353..393 CDD:214531
LY 397..437 CDD:214531
Ldl_recept_b 458..499 CDD:459654
LY 483..524 CDD:214531
LY 525..558 CDD:214531
FXa_inhibition 592..627 CDD:464251
Beta-propeller 3 631..890 11/53 (21%)
YncE <654..813 CDD:442618
LY 697..739 CDD:214531
LY 827..866 CDD:214531 6/27 (22%)
FXa_inhibition 893..929 CDD:464251 9/56 (16%)
LY 958..998 CDD:214531 9/39 (23%)
YncE <968..1075 CDD:442618 29/123 (24%)
LY 1094..1132 CDD:214531 9/37 (24%)
FXa_inhibition 1238..1274 CDD:464251 3/35 (9%)
LDLa 1280..1316 CDD:238060 6/63 (10%)
LDLa 1319..1353 CDD:238060 14/34 (41%)
LDLa 1357..1391 CDD:238060 12/64 (19%)
PPPSP motif A 1518..1524 2/5 (40%)
PPPSP motif B 1558..1565 2/6 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1587..1644 3/4 (75%)
PPPSP motif C 1599..1606
PPPSP motif D 1619..1624
PPPSP motif E 1634..1641
CuldNP_729364.1 CUB 200..298 CDD:238001 31/113 (27%)
LDLa 442..472 CDD:238060 14/31 (45%)
Blue background indicates that the domain is not in the aligned region.

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