DRSC/TRiP Functional Genomics Resources

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Protein Alignment LRP6 and CG6553

DIOPT Version :10

Sequence 1:NP_001401173.1 Gene:LRP6 / 4040 HGNCID:6698 Length:1644 Species:Homo sapiens
Sequence 2:NP_610911.1 Gene:CG6553 / 36537 FlyBaseID:FBgn0033880 Length:319 Species:Drosophila melanogaster


Alignment Length:249 Identity:66/249 - (26%)
Similarity:87/249 - (34%) Gaps:101/249 - (40%)


- Green bases have known domain annotations that are detailed below.


Human  1269 QDELSCGEPPTCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDE--LNCPV--CSESQFQCASG 1329
            |:..|||.         .|..|  |||.:...|||...|.|.|||  ..|..  |....|:|:.|
  Fly    27 QNATSCGH---------RCGGG--DCIQLDQLCDGSANCLDGSDETVAMCEKVWCPGYAFRCSYG 80

Human  1330 QCIDGALRCNGDANCQDKSDEK-----------NCEVLCLIDQFRCANGQCIGKHKKCDHNVDCS 1383
            .||.....|:|..:|.|.|||:           ||:..    :..|::|||:...|.||...||.
  Fly    81 ACIASTAVCDGVQDCVDGSDEQGWLCRAQMQQANCDNW----EMYCSSGQCMTYSKLCDGIRDCR 141

Human  1384 DKSDELD--C----YPT--------------------------------------EEPAPQATN- 1403
            |..|||:  |    .||                                      |...||..| 
  Fly   142 DGDDELESLCEGVTIPTTTVSSTTSTTTESSIHRITPTVPVTRKASRPNPLQENGECVVPQLPNV 206

Human  1404 ----------TVGSVIGVIVTIFVSGT-VYFICQRMLCP---RMKGDGETMTND 1443
                      ||||.:       .:|| :|:.     ||   |:||:.:.:..|
  Fly   207 MVKHFTDAILTVGSRV-------ANGTRIYYD-----CPAEHRLKGENQNICQD 248

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LRP6NP_001401173.1 YncE 1..204 CDD:442618
Beta-propeller 1 20..275
LY 89..127 CDD:214531
Ldl_recept_b 150..191 CDD:459654
LY 175..216 CDD:214531
LY 217..251 CDD:214531
LDL-receptor class B 5 237..276
FXa_inhibition 286..323 CDD:464251
Beta-propeller 2 328..589
LY 353..393 CDD:214531
LY 397..437 CDD:214531
Ldl_recept_b 458..499 CDD:459654
LY 483..524 CDD:214531
LY 525..558 CDD:214531
FXa_inhibition 592..627 CDD:464251
Beta-propeller 3 631..890
YncE <654..813 CDD:442618
LY 697..739 CDD:214531
LY 827..866 CDD:214531
FXa_inhibition 893..929 CDD:464251
LY 958..998 CDD:214531
YncE <968..1075 CDD:442618
LY 1094..1132 CDD:214531
FXa_inhibition 1238..1274 CDD:464251 1/4 (25%)
LDLa 1280..1316 CDD:238060 13/37 (35%)
LDLa 1319..1353 CDD:238060 13/44 (30%)
LDLa 1357..1391 CDD:238060 13/35 (37%)
PPPSP motif A 1518..1524
PPPSP motif B 1558..1565
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1587..1644
PPPSP motif C 1599..1606
PPPSP motif D 1619..1624
PPPSP motif E 1634..1641
CG6553NP_610911.1 LDLa 34..60 CDD:197566 11/36 (31%)
LDLa 70..101 CDD:197566 11/30 (37%)
LDLa 115..146 CDD:197566 11/34 (32%)
Blue background indicates that the domain is not in the aligned region.

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