DRSC/TRiP Functional Genomics Resources

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Protein Alignment: LRP6 and CG6553

Sequence 1:NP_002327.2 Gene:LRP6 HGNCID:6698 Length:1613 Species:Homo sapiens
Sequence 2:NP_610911.1 Gene:CG6553 FlyBaseID:FBgn0033880 Length:319 Species:Drosophila melanogaster

Alignment Length:249 Identity:66/250 (26%)
Similarity:87/250 (35%) Gaps:101/250 (40%)


Human  1238 QDELSCGEPPTCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDE--LNCPV--CSESQFQCASG 1298
            |:..|||.         .|..|  |||.:...|||...|.|.|||  ..|..  |....|:|:.|
  Fly    27 QNATSCGH---------RCGGG--DCIQLDQLCDGSANCLDGSDETVAMCEKVWCPGYAFRCSYG 80

Human  1299 QCIDGALRCNGDANCQDKSDEK-----------NCEVLCLIDQFRCANGQCIGKHKKCDHNVDCS 1352
            .||.....|:|..:|.|.|||:           ||:..    :..|::|||:...|.||...||.
  Fly    81 ACIASTAVCDGVQDCVDGSDEQGWLCRAQMQQANCDNW----EMYCSSGQCMTYSKLCDGIRDCR 141

Human  1353 DKSDELD--C----YPT--------------------------------------EEPAPQATN- 1372
            |..|||:  |    .||                                      |...||..| 
  Fly   142 DGDDELESLCEGVTIPTTTVSSTTSTTTESSIHRITPTVPVTRKASRPNPLQENGECVVPQLPNV 206

Human  1373 ----------TVGSVIGVIVTIFVSGT-VYFICQRMLCP---RMKGDGETMTND 1412
                      ||||.:       .:|| :|:.     ||   |:||:.:.:..|
  Fly   207 MVKHFTDAILTVGSRV-------ANGTRIYYD-----CPAEHRLKGENQNICQD 248

Known Domains:


GeneSequenceDomainRegion External IDIdentity
LRP6NP_002327.2 Beta-propeller 1 20..275
NHL 55..272 CDD:302697
NHL repeat 55..93 CDD:271320
LY 89..127 CDD:214531
NHL repeat 97..132 CDD:271320
NHL repeat 140..176 CDD:271320
Ldl_recept_b 150..190 CDD:278487
LY 175..216 CDD:214531
NHL repeat 181..217 CDD:271320
NHL repeat 226..253 CDD:271320
LDL-receptor class B 5 237..276
FXa_inhibition 286..323 CDD:291342
Beta-propeller 2 328..589
LY 353..393 CDD:214531
LY 397..437 CDD:214531
LY 438..481 CDD:214531
LY 483..524 CDD:214531
LY 525..558 CDD:214531
FXa_inhibition 592..627 CDD:291342
Beta-propeller 3 631..890
LY 656..694 CDD:214531
LY 697..739 CDD:214531
LY 740..783 CDD:214531
LY 783..825 CDD:214531
LY 827..866 CDD:214531
FXa_inhibition 893..929 CDD:291342
Beta-propeller 4 933..1202
LY 958..998 CDD:214531
Ldl_recept_b 1069..1110 CDD:278487
LY 1094..1136 CDD:214531
FXa_inhibition 1207..1243 CDD:291342 2/5 (40%)
LDLa 1249..1285 CDD:238060 13/38 (34%)
LDLa 1288..1322 CDD:238060 14/45 (31%)
LDLa 1326..1360 CDD:238060 13/36 (36%)
PPPSP motif A 1487..1493
PPPSP motif B 1527..1534
PPPSP motif C 1568..1575
PPPSP motif D 1588..1593
PPPSP motif E 1603..1610
CG6553NP_610911.1 LDLa 34..60 CDD:197566 12/37 (32%)
LDLa 70..101 CDD:197566 12/31 (39%)
LDLa 115..146 CDD:197566 12/35 (34%)
Frag1 <260..>303 CDD:287278
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
eggNOG 1 0.900 E1_KOG1215
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 O PTHR24270
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
22.000

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