DRSC/TRiP Functional Genomics Resources

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Protein Alignment LRP6 and LRP1

DIOPT Version :10

Sequence 1:NP_001401173.1 Gene:LRP6 / 4040 HGNCID:6698 Length:1644 Species:Homo sapiens
Sequence 2:NP_001260800.2 Gene:LRP1 / 35799 FlyBaseID:FBgn0053087 Length:4752 Species:Drosophila melanogaster


Alignment Length:1786 Identity:517/1786 - (28%)
Similarity:782/1786 - (43%) Gaps:359/1786 - (20%)


- Green bases have known domain annotations that are detailed below.


Human    21 PLLLYANRRDLRLVDATNGKENATIVVG----GLEDAAAVDFVF---SHGLIYWSDVSEEAIKRT 78
            |.:::.||:|::      |....|:.||    .|.:..|:||::   |:..|||:||.::.|.|.
  Fly  1365 PYVIFTNRQDIK------GINLKTLNVGNFYSSLRNIIALDFLYNNESNVEIYWTDVIDDKIYRG 1423

Human    79 EF--NKTESVQNVVVSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQPR 141
            ..  ....:|:.|:.|||.:.:|||.||:|:.|||.||..::|||:.|:||.|:.|....::.||
  Fly  1424 HLVGESLRNVEAVIHSGLSTTEGLAVDWVGKNLYWIDSNLDQIEVAKLNGSFRRTLIAGNMESPR 1488

Human   142 AIALDPSSGFMYWTDWGE-VPKIERAGMDGSSRFIIINS---EIYWPNGLTLDYEEQKLYWADAK 202
            ||||||..|.::||||.: .|:||||.|.|..|.:|..|   ...|||||||||.::::||.|||
  Fly  1489 AIALDPREGLLFWTDWDDNSPRIERASMSGDGRRMISTSWQLSAGWPNGLTLDYTQKRVYWVDAK 1553

Human   203 LNFIHKSNLDGTNRQAVVKGS--LPHPFALTLFEDILYWTDWSTHSILACNKYTGEGLREIHSDI 265
            .:.|..:..||:....|::..  |.||||:::||:.:|||||.|.|::..||:.|..::.:....
  Fly  1554 SDSISSTMYDGSEHHVVLRNKEILSHPFAISVFENYVYWTDWRTTSVIRANKWNGSDVQVLQRTQ 1618

Human   266 FSPMDIHAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKL-LENGKTCKDGATE 329
            ..|..|......|||...||||.:|||||||||:|. :..::|.||..::| ..|.:.|... .:
  Fly  1619 SQPFGIQVLHSSRQPWDRNPCGENNGGCSHLCLLSG-RGTFKCECPHVMRLDPANERNCVPN-EQ 1681

Human   330 LLLLARRTDLRRISLDTPDFTDI--VLQLEDIRHAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGS 392
            :||.....::|.|.|..|:...|  :.|...:.....||:...|..|:|:|.:...|..:.|...
  Fly  1682 VLLFVMVDEIRGIDLHQPNHHTIPTIRQSPRLVAPQRIDFLVDESRIFWSDIQQNEISSAGISNG 1746

Human   393 GSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEV--TRLNGTMRKILISEDLEEPRAIVLDP 455
            ..:.::...|..|.|.||||:|||:|:: :|..:..:  :.|.|....| |.|||....:|||||
  Fly  1747 LIEPIINTNIEKPYGFAVDWIARNMYFS-SGQIKCNILASNLKGEFASI-IHEDLNMVDSIVLDP 1809

Human   456 MVGYMYW----TDWGEIPKIERAALDGSDRVVLV--NTSLGWPNGLALDYDEGKIYWGDAKTDKI 514
            ..|.|||    :| |.:.::|::.||||.|.::.  ..:|   ..|.:|:|..::|:.       
  Fly  1810 ANGKMYWIHSASD-GSMSQLEQSNLDGSSRSLIYQHENNL---QSLTMDFDSQRLYYA------- 1863

Human   515 EVMNTDGTG-----------RRVLVEDKIPHIFGFTLLGDYVYWTDWQRRSIERVHKRS-AEREV 567
                .|.:|           |:|||...|..|...|:....:|:.:..:..|.:..|.: :....
  Fly  1864 ----YDNSGIAYYDIPRNETRKVLVASPITSISSLTVYNGTLYFPENIQSVIMQCEKEACSNMSY 1924

Human   568 IIDQLPDLMGLKATNVHRVIGSNPCAE--ENGGCSHLCLYRPQ-GLRCACPIGFELISDMKTCIV 629
            :......:..:|........|||.|||  ..|||..|||.... ...|.|.:|:::..:..|..|
  Fly  1925 LRVNTKSIQSMKMFYADAQTGSNTCAEWAYRGGCQQLCLATSSIDHVCRCALGYDVEPNNPTGCV 1989

Human   630 PEAFLLF--------------SRRADIRRISLETNNNNVAIPLTGVKEASALDFDVTDNRIYWTD 680
            |.|..:|              |.:.|....:|        :|::.|..||.:|:....:.:||.|
  Fly  1990 PRAEFIFYSIDVLQGVEMIDPSEQFDTPSPAL--------VPISRVSSASFIDYLANTDTLYWGD 2046

Human   681 ISLKTISRAFMNGSALEHVVE----FGL---DYPEGMAVDWLGKNLYWADTGTNRIEVSKLDGQH 738
            ..|.:|||...:|:..|.::|    .|.   |:..|:|:||:..|:||:||..|.|||::|||.|
  Fly  2047 NELGSISRVKRDGTQRETILEALNLVGYKQQDWLGGIAIDWVAGNIYWSDTKRNIIEVARLDGSH 2111

Human   739 RQVLVWKDLDSPRALALDPAEGFMYWTEWGGKPKIDRAAMDGSERTTLVPNVGRAN----GLTID 799
            |.|:| .:|:.|.|||:||.:|.:::..   :..|.|..:|||:...|| |..|||    .|.:|
  Fly  2112 RYVVV-SNLEKPTALAVDPLQGLLFYVT---QQHIGRVGLDGSQPFVLV-NQTRANWAVGSLVLD 2171

Human   800 YAKRRLYW----------TDLDTNLIESSNMLGLNREVIADDLPHPFGLTQYQDYIYWTD--WSR 852
            ....::||          .|.|.||.|         :::.:.|.:|..|.:..||:||.:  ::.
  Fly  2172 IEATKVYWCERYPDALMKVDYDGNLRE---------QLLNESLNNPVALAKMGDYLYWAENKYNE 2227

Human   853 RSIERANKTS-GQNRTIIQGHLDYVMDILVFHSSRQSGWNECASSNGHCSHLCLAVPVGGFVCGC 916
            ..|..|...: .|::.::|...|.:.|:.::....|.|.|.||.|||.|..|||...... ||.|
  Fly  2228 GIIRVAPLANLSQSKVVLQTEQDAIRDLKIYSKHLQRGSNPCAHSNGACEQLCLFNGTSA-VCAC 2291

Human   917 PAHYSLNADNRTCSAPTTFLLFSQKSAINRMVI----DEQQSPDIILPIHSLRNVRAIDYDPLDK 977
             ||..|.:|..:|.....|||||.:|.|..:.:    |:.....:|.....:|||.||.|:..::
  Fly  2292 -AHSRLASDGYSCEPYENFLLFSYRSNIESIHMTDHADKNWPVQMISNTSLMRNVIAITYNYEEQ 2355

Human   978 QLYWIDSRQNMIRKAQEDGSQGFTVVVSSVPSQNLEIQPYDLSIDIYSRYIYWTCEATNVINVTR 1042
            .:|:.|.:.:.|.:...:|: |..|::..  .|.:|    .|:.||.:..::||......|....
  Fly  2356 LVYYSDVQLSTINQVHFNGT-GHRVLLEQ--QQRVE----GLAYDIVNEQLFWTSNNNATIRSVE 2413

Human  1043 L-------DGRSVGV--VLK-GEQDRPRAVVVNPEKGYMYFTNLQERSPKIERAALDGTEREVLF 1097
            |       |...|.|  ||. .|.|:||.:.|.|..|.:|:||..|.||.|:|:.|.|...||:.
  Fly  2414 LRHLSEHADQNQVHVKKVLSLREDDKPRGIAVEPCLGMIYWTNWNEGSPCIQRSYLTGYGTEVII 2478

Human  1098 FSGLSKPIALALDSRLGKLFWADSDLRRIESSDLSEMAFCHVAQADVELLGSRDPPASASQITEI 1162
            .:.:..|.||.||....||:|||:.|.:||.                               |..
  Fly  2479 KTDIKMPNALTLDLEQQKLYWADARLDKIER-------------------------------TNY 2512

Human  1163 TGANRIVLEDSNILQPVGLTVFENWLYWIDKQQQMIEKID-MTG------REGRTKVQARIA-QL 1219
            .|:||:||..|.......:.|:.:.|:|.|.....:.:.: .||      ||..|:....:| |.
  Fly  2513 DGSNRVVLAHSTPKHAFAMAVYGDLLFWTDWVLHAVVRANKYTGTDVLFLREHVTRPMGIVAVQN 2577

Human  1220 SDIHAVKELNLQEYRQHPCAQDNGGCSHICLVKGDGTTRCSCPMHLVLLQDELSCGEP--PTCSP 1282
            :.|:.         ..:.|...||.|..:|::...|...|.|... ||..|...|..|  .:|..
  Fly  2578 TSINC---------DANQCKILNGQCEDVCILNKSGQATCHCTQG-VLAPDGRRCIAPVNTSCGL 2632

Human  1283 QQFTCFTGEIDCIPVAWRCDGFTECEDHSDELN--C--PVCSESQFQCASGQCIDGALRCNGDAN 1343
            .|:.|.:||  |||:...||..|.|.|.|||..  |  ..|.|:.|.|.:.:||....:|:|:..
  Fly  2633 SQYNCHSGE--CIPLELTCDNVTHCADGSDEFRSYCIFRQCPETHFMCQNHRCIPKEHKCDGEQQ 2695

Human  1344 CQDKSDEKNCEVLC------------------LIDQFRCANGQCIGKHKKCDHNVDCSDKSDELD 1390
            |.|.|||  ..:||                  :.|.|||.:|:||.:...||...||.|.|||..
  Fly  2696 CGDGSDE--TPLLCKCQSEDIDMHPSNNNTKEMPDMFRCGSGECIPRKFLCDSLKDCRDFSDEKM 2758

Human  1391 CYPTEEPAPQATNTVGSVIGVIVTIFVSGTVYFICQRMLCPRMKGDGETMTNDYVVHGPASVPLG 1455
            |    .|.|...|.:         .||......||   :.||.:.||:....|      .:..|.
  Fly  2759 C----APIPCEKNDM---------TFVHCGNSTIC---IMPRWRCDGDPDCPD------GTDELD 2801

Human  1456 YVPHPSSLSGSLPGMSR---GKSMISSLSIMGGSSGP-----------------PYDRAHV---- 1496
            ...| :|||.. ||..|   |..:..|....|....|                 ..|:..:    
  Fly  2802 CANH-TSLSCD-PGQFRCASGNCIAGSWHCDGEKDCPDGSDEINCRTECRHNQFACDKTCIPASW 2864

Human  1497 --TGASSSSSSSTKGTYFPAILNPPPSPATERSHYTMEFGYSSNSPSTHRSYSYRPYSYRHFAPP 1559
              .|.|.....|.:|...|                        |.|.       ||:.::     
  Fly  2865 QCDGKSDCEDGSDEGPQCP------------------------NRPC-------RPHLFQ----- 2893

Human  1560 TTPCSTD--------VCDSDY-APSRRMTSVATAKGYTSDLNYDSEP-------VPPPPTPR--- 1605
               |.:.        |||.:. .||          |...:.:.|..|       :|..|.|.   
  Fly  2894 ---CKSSGRCIPQKWVCDGEKDCPS----------GLGDEGSEDEGPQCGGVAHIPDCPPPAHLC 2945

Human  1606 -------SQYL--------SAEENYESCPPS 1621
                   |.|:        ..::.||.|.|:
  Fly  2946 TSGLCIDSHYVCDGDEDCPGGDDEYEGCVPA 2976

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LRP6NP_001401173.1 YncE 1..204 CDD:442618 81/195 (42%)
Beta-propeller 1 20..275 104/268 (39%)
LY 89..127 CDD:214531 19/37 (51%)
Ldl_recept_b 150..191 CDD:459654 22/44 (50%)
LY 175..216 CDD:214531 19/43 (44%)
LY 217..251 CDD:214531 15/35 (43%)
LDL-receptor class B 5 237..276 12/38 (32%)
FXa_inhibition 286..323 CDD:464251 17/37 (46%)
Beta-propeller 2 328..589 70/282 (25%)
LY 353..393 CDD:214531 9/39 (23%)
LY 397..437 CDD:214531 14/41 (34%)
Ldl_recept_b 458..499 CDD:459654 14/46 (30%)
LY 483..524 CDD:214531 7/53 (13%)
LY 525..558 CDD:214531 8/32 (25%)
FXa_inhibition 592..627 CDD:464251 12/37 (32%)
Beta-propeller 3 631..890 84/296 (28%)
YncE <654..813 CDD:442618 62/179 (35%)
LY 697..739 CDD:214531 20/48 (42%)
LY 827..866 CDD:214531 10/41 (24%)
FXa_inhibition 893..929 CDD:464251 16/35 (46%)
LY 958..998 CDD:214531 11/39 (28%)
YncE <968..1075 CDD:442618 31/116 (27%)
LY 1094..1132 CDD:214531 15/37 (41%)
FXa_inhibition 1238..1274 CDD:464251 11/35 (31%)
LDLa 1280..1316 CDD:238060 16/37 (43%)
LDLa 1319..1353 CDD:238060 13/33 (39%)
LDLa 1357..1391 CDD:238060 16/51 (31%)
PPPSP motif A 1518..1524 0/5 (0%)
PPPSP motif B 1558..1565 1/6 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1587..1644 11/60 (18%)
PPPSP motif C 1599..1606 3/16 (19%)
PPPSP motif D 1619..1624 1/3 (33%)
PPPSP motif E 1634..1641
LRP1NP_001260800.2 LDLa 87..118 CDD:197566
LDLa 126..163 CDD:238060
EGF_CA 246..283 CDD:214542
Ldl_recept_b 449..487 CDD:459654
LY 472..513 CDD:214531
LY 817..852 CDD:214531
LDLa 1057..1092 CDD:197566
LDLa 1104..1134 CDD:238060
LDLa 1191..1226 CDD:238060
FXa_inhibition 1289..1317 CDD:464251
LY 1434..1476 CDD:214531 21/41 (51%)
LY 1477..1521 CDD:214531 21/43 (49%)
LY 1533..1567 CDD:214531 17/33 (52%)
LY 1568..1611 CDD:214531 18/42 (43%)
FXa_inhibition 1639..1676 CDD:464251 17/37 (46%)
LY 1751..1789 CDD:214531 13/38 (34%)
LY 1794..1838 CDD:214531 21/45 (47%)
LY 2078..2112 CDD:214531 17/33 (52%)
NHL <2082..>2152 CDD:302697 33/73 (45%)
NHL repeat 2082..2120 CDD:271320 20/38 (53%)
FXa_inhibition 2269..2303 CDD:464251 16/35 (46%)
LY 2430..2471 CDD:214531 18/40 (45%)
LY 2475..2517 CDD:214531 17/72 (24%)
LDLa 2630..2661 CDD:238060 14/32 (44%)
LDLa 2671..2702 CDD:238060 11/30 (37%)
LDLa 2727..2759 CDD:238060 15/31 (48%)
LDLa 2773..2802 CDD:238060 8/37 (22%)
LDLa 2810..2844 CDD:238060 7/34 (21%)
LDLa 2848..2878 CDD:238060 4/29 (14%)
LDLa 2887..2916 CDD:197566 8/53 (15%)
LDLa 2938..2969 CDD:197566 4/30 (13%)
LDLa 2989..3015 CDD:197566
LDLa 3030..3061 CDD:238060
EGF_CA 3062..>3091 CDD:214542
EGF_CA 3103..3141 CDD:214542
LY 3212..3254 CDD:214531
Ldl_recept_b 3275..3314 CDD:459654
LY 3299..3340 CDD:214531
LY 3354..3389 CDD:214531
LDLa 3458..3490 CDD:238060
LDLa 3499..3533 CDD:238060
LDLa 3582..3616 CDD:238060
LDLa 3621..3652 CDD:197566
LDLa 3663..3697 CDD:238060
LDLa 3702..3736 CDD:238060
LDLa 3776..3808 CDD:197566
LDLa 3818..3849 CDD:197566
LDLa 3860..3894 CDD:238060
YncE 3935..4148 CDD:442618
LY 4108..4150 CDD:214531
EGF_CA <4386..4414 CDD:238011
EGF_CA 4415..4450 CDD:238011
Blue background indicates that the domain is not in the aligned region.

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