DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment LRP6 and Lrp4

DIOPT Version :10

Sequence 1:NP_001401173.1 Gene:LRP6 / 4040 HGNCID:6698 Length:1644 Species:Homo sapiens
Sequence 2:NP_727914.1 Gene:Lrp4 / 32552 FlyBaseID:FBgn0030706 Length:2009 Species:Drosophila melanogaster


Alignment Length:1301 Identity:507/1301 - (38%)
Similarity:763/1301 - (58%) Gaps:80/1301 - (6%)


- Green bases have known domain annotations that are detailed below.


Human     2 GAVLRSLLACSFCVLLRAAPLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIY 66
            |.:||..|..  |..|..|..||.|||.|:|.|..:|.:.:|  :|.||.:|.|:||....||::
  Fly   594 GYILRPDLRS--CKALGGAMTLLVANRWDIRRVTLSNNRYSA--IVKGLHNAIALDFHHRKGLMF 654

Human    67 WSDVSEEAIKRTEFNKTESVQNVVVSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKV 131
            |||||.:.||....|.|. |::|:..||.||.|:|.||:.:.|:||||.|.|:||||..|:||.|
  Fly   655 WSDVSTDVIKMVYMNGTR-VRDVIKWGLESPGGIAVDWIHDLLFWTDSGTRRVEVSNFQGNLRTV 718

Human   132 LFWQELDQPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSEIYWPNGLTLDYEEQKL 196
            :...:||:||||.:.|.....:|:|||..||||||.|||:.|.:||:..:.|||||.:|:...|:
  Fly   719 IASYDLDKPRAIVVHPGEALAFWSDWGPNPKIERAYMDGTQRKVIISKGVTWPNGLAIDFPNSKI 783

Human   197 YWADAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDILYWTDWSTHSILACNKYTGEGLREI 261
            ||||||.:.|..|||||::|..::...||||||||||||.:|||||:|.::.|.:|.||:..|.:
  Fly   784 YWADAKQHAIECSNLDGSDRNKILSTHLPHPFALTLFEDTMYWTDWNTKTVSAADKITGKEFRAV 848

Human   262 HSDIFSPMDIHAFSQQRQPNATNPCGID----NGGCSHLCLMSPVKPFYQCACPTGVKLLENGKT 322
            |.:...||||||:...|||...:.|..|    .||||||||  |.|...:|.||.|:.|.|:|||
  Fly   849 HENFHFPMDIHAYHPARQPEYADRCQKDRRGLRGGCSHLCL--PNKTSRRCGCPIGLSLKEDGKT 911

Human   323 CKDGATELLLLARRTDLR----RISLDTPDFTDIVLQLEDIRHAIAIDYDPVEGYIYWTDDEVRA 383
            ||..|.:|:|:|||.|:|    |.:...|:..|:::.|::::||:|:|:.....:|||||.|...
  Fly   912 CKSTADKLVLVARRKDIRLRHLRDNQADPNDVDMIVPLDNLKHAVALDWCSDTDFIYWTDVERST 976

Human   384 IRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEP 448
            |.::.::||..|.||.:.:..|.|:|:||:...|||||..|:||||...||.||.:||.|.|.:|
  Fly   977 INKAHLNGSYQQRVVHSNLVSPVGLALDWITDKLYWTDPSTNRIEVATTNGKMRTLLIWEKLYKP 1041

Human   449 RAIVLDPMVGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDK 513
            |.||::|:.|:|:|:|||:.|.||||.:||.:||.:.:..|.:|||||:||::.|||:.|..|..
  Fly  1042 RDIVVNPIEGFMFWSDWGDDPMIERANMDGHERVTITSKKLIYPNGLAIDYEKSKIYFVDGGTKT 1106

Human   514 IEVMNTDGTGRRVLVEDKIPHIFGFTLLGDYVYWTDWQRRSIERVHKRSA-EREVIIDQLPDLMG 577
            :|.||.||:||:|:: :.:.|.||..:....|:||||..:|:...:|.:. :..|||....|||.
  Fly  1107 LENMNFDGSGRQVIL-NGLGHPFGLDVNEGRVFWTDWDTKSVMSANKLTGKDTNVIIANSTDLMD 1170

Human   578 LKATNVHRVIGSNPCAEENGGCSHLCLYRPQGLRCACPIGFELISDMKTCIV-PEAFLLFSRRAD 641
            ::..:..|....|.|.:.|||||||||..|....|||.:|.:|..|..||.. |..::||:.|.|
  Fly  1171 IRVFHRTRRRIFNACDKLNGGCSHLCLLNPTSYTCACTVGVQLKEDRHTCSEGPTQYILFAHRID 1235

Human   642 IRRISLETNN-NNVAIPLTGVKEASALDFDVTDNRIYWTDISLKTISRAFMNGSALEHVVEFGLD 705
            ||:|||:.:: .:|.:||..:..|.|||.|.....|||:|.....|..:..:|..::.:|...|:
  Fly  1236 IRQISLDFDHLIDVVLPLPPISNAVALDVDRKTGYIYWSDTIENVIMSSSPDGLHVQKIVGDSLE 1300

Human   706 YPEGMAVDWLGKNLYWADTGTNRIEVSKLDGQHRQVLVWKDLDSPRALALDPAEGFMYWTEWGGK 770
            .|:|:.||.:|:.:||||.|.:.|||:.|||.:|.|:.:|||:|||.||||...|.::||:||..
  Fly  1301 NPDGLVVDSIGRTIYWADAGRHTIEVASLDGSNRHVIAYKDLESPRGLALDYEAGLLFWTDWGHY 1365

Human   771 PKIDRAAMDGSERTTLV-PNVGRANGLTIDYAKRRLYWTDLDTNLIESSNMLGLNREVIADDLPH 834
            .||:|:.:||:||:.:| .|:|..|||::|...:|:||.|.....|:|.:..|..|::|...|.|
  Fly  1366 RKIERSHLDGNERSRIVTANLGWPNGLSLDLKSKRIYWVDARLKTIDSCDYTGNQRKLIMSSLHH 1430

Human   835 PFGLTQYQDYIYWTDWSRRSI---ERANKTSGQNRTIIQGHLDYVMDI-LVFHSSRQSGW-NECA 894
            |:.|....|.||||||..:::   ||.|.::  .|.||. ::|.:||| :::.:..||.. |.|.
  Fly  1431 PYALALSDDNIYWTDWKSKALHMTERRNISA--KRDIIT-NIDGLMDIKIIYQNQNQSTMKNACG 1492

Human   895 SSNGHCSHLCLAVPVGGFVCGCPAHYSLNADNRT-C-SAPTTFLLFSQKSAINRMVIDEQQSPDI 957
            ::||:||||||..| .|:.|.||....|..::.| | :.|..:||.:.:|.|..:.::.....|:
  Fly  1493 NNNGNCSHLCLRNP-SGYSCQCPIGLRLRQNSTTQCQNLPEDYLLIALRSGIGMISLNSGDFMDV 1556

Human   958 ILPIHSLRNVRAIDYDPLDKQLYWIDSRQNMIRKAQ-EDGSQGFTVVVSSVPSQNLEIQPYDLSI 1021
            :|||:.:.....:||......|::.|...::||:.. .:.::...:|.:.|      :.|..:::
  Fly  1557 VLPINGVHGAVVLDYHYRKNLLFFADVNLDVIRRVNLLNLTESKVIVGTDV------LTPNGIAV 1615

Human  1022 DIYSRYIYWTCEATNVINVTRLDGRSVGVVLKGEQDRPRAVVVNPEKGYMYFTNLQERSP-KIER 1085
            |..:..:||:.....:|.|:||||.....:::.....||:::|:|:|.|:::::..  || ||||
  Fly  1616 DWIADNLYWSDTDRKLIEVSRLDGSCRKRIVEDNLGDPRSLIVHPKKAYLFWSDWS--SPAKIER 1678

Human  1086 AALDGTEREVLFFSGLSKPIALALDSRLGKLFWADSDLRRIESSDLSEMAFCHVAQADVELLGSR 1150
            :.|||:.|.|:..||:..|..|.:|....:|.|||:    :|.         ::.|.|..  |.|
  Fly  1679 SYLDGSNRTVIITSGIGFPTGLTIDFTNRRLLWADA----LED---------NIGQVDFN--GKR 1728

Human  1151 DPPASASQITEITGANRIVLEDSNILQPVGLTVFEN---WLYWIDKQQQMIEKIDMTGREGRTKV 1212
                   :.|.:..|.          .|.|||:|||   |..|.:|.....:|:..:|.....:|
  Fly  1729 -------RQTIVPYAP----------HPFGLTLFENSIFWTDWYNKSVYRSQKLARSGYGNPFEV 1776

Human  1213 QARIAQLSDIHAVKELNLQEYRQHPCAQDNGGCSHICLVKGDGTTRCSCPMHLVLLQDELSCGEP 1277
            :..::...||.|| .|:.|....:.||||||||:|:||.:..... |:||.  |:...:::|...
  Fly  1777 RDALSGALDIRAV-SLSRQPKSVNHCAQDNGGCTHLCLNRNVDYV-CACPD--VMDPKDVACSIK 1837

Human  1278 P 1278
            |
  Fly  1838 P 1838

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LRP6NP_001401173.1 YncE 1..204 CDD:442618 96/201 (48%)
Beta-propeller 1 20..275 127/254 (50%)
LY 89..127 CDD:214531 20/37 (54%)
Ldl_recept_b 150..191 CDD:459654 21/40 (53%)
LY 175..216 CDD:214531 21/40 (53%)
LY 217..251 CDD:214531 19/33 (58%)
LDL-receptor class B 5 237..276 18/38 (47%)
FXa_inhibition 286..323 CDD:464251 20/40 (50%)
Beta-propeller 2 328..589 108/265 (41%)
LY 353..393 CDD:214531 13/39 (33%)
LY 397..437 CDD:214531 19/39 (49%)
Ldl_recept_b 458..499 CDD:459654 21/40 (53%)
LY 483..524 CDD:214531 18/40 (45%)
LY 525..558 CDD:214531 10/32 (31%)
FXa_inhibition 592..627 CDD:464251 17/34 (50%)
Beta-propeller 3 631..890 104/264 (39%)
YncE <654..813 CDD:442618 67/159 (42%)
LY 697..739 CDD:214531 18/41 (44%)
LY 827..866 CDD:214531 15/41 (37%)
FXa_inhibition 893..929 CDD:464251 16/36 (44%)
LY 958..998 CDD:214531 9/40 (23%)
YncE <968..1075 CDD:442618 24/107 (22%)
LY 1094..1132 CDD:214531 11/37 (30%)
FXa_inhibition 1238..1274 CDD:464251 15/35 (43%)
LDLa 1280..1316 CDD:238060
LDLa 1319..1353 CDD:238060
LDLa 1357..1391 CDD:238060
PPPSP motif A 1518..1524
PPPSP motif B 1558..1565
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1587..1644
PPPSP motif C 1599..1606
PPPSP motif D 1619..1624
PPPSP motif E 1634..1641
Lrp4NP_727914.1 LDLa 267..301 CDD:238060
LDLa 306..340 CDD:238060
LDLa 347..390 CDD:238060
LDLa 397..431 CDD:238060
LDLa 442..476 CDD:238060
LDLa 480..521 CDD:238060
FXa_inhibition 576..604 CDD:464251 4/11 (36%)
LY 634..671 CDD:214531 17/36 (47%)
LY 680..714 CDD:214531 19/33 (58%)
LY 718..760 CDD:214531 21/41 (51%)
Ldl_recept_b 740..777 CDD:459654 21/36 (58%)
LY 761..803 CDD:214531 21/41 (51%)
LY 806..838 CDD:214531 19/31 (61%)
FXa_inhibition 882..912 CDD:464251 18/31 (58%)
LY 946..985 CDD:214531 12/38 (32%)
NHL <967..1142 CDD:302697 82/175 (47%)
LY 988..1030 CDD:214531 20/41 (49%)
NHL repeat 998..1037 CDD:271333 21/38 (55%)
NHL repeat 1038..1080 CDD:271333 21/41 (51%)
NHL repeat 1084..1119 CDD:271333 19/34 (56%)
FXa_inhibition 1185..1220 CDD:464251 17/34 (50%)
NHL 1260..>1445 CDD:302697 76/184 (41%)
NHL repeat 1260..1296 CDD:271320 10/35 (29%)
LY 1292..1334 CDD:214531 18/41 (44%)
NHL repeat 1302..1337 CDD:271320 17/34 (50%)
NHL repeat 1345..1383 CDD:271320 18/37 (49%)
FXa_inhibition <1499..1525 CDD:464251 11/26 (42%)
LY 1600..1640 CDD:214531 11/45 (24%)
LY 1643..1686 CDD:214531 15/44 (34%)
LY 1688..1729 CDD:214531 15/62 (24%)
FXa_inhibition 1801..>1825 CDD:464251 13/24 (54%)
Blue background indicates that the domain is not in the aligned region.

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