DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment LRP6 and LpR1

DIOPT Version :9

Sequence 1:	NP_002327.2	Gene:	LRP6 / 4040	HGNCID:	6698	Length:	1613	Species:	Homo sapiens
Sequence 2:	NP_001097934.2	Gene:	LpR1 / 2768687	FlyBaseID:	FBgn0066101	Length:	1076	Species:	Drosophila melanogaster

Alignment Length:	419	Identity:	160/419 - (38%)
Similarity:	226/419 - (53%)	Gaps:	40/419 - (9%)

- Green bases have known domain annotations that are detailed below.

Human    23 LLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKRTEFNKTESVQ 87
            ||.|.|.|:|.: |.:..| .|.:|...:.|.|:||||..|:|:||||:.::|.:...::.....
  Fly   599 LLLARRHDIRKI-ALDHME-MTSIVNSTKAATALDFVFRTGMIFWSDVTTQSIYKAPIDEGNEKT 661

Human    88 NVVVSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQPRAIALDPSSGFM 152
            .|:....::.||||.||:...:|:||:....||::|.:||:.|||....||.||:|||||..|:|
  Fly   662 VVLTKSSVTSDGLAVDWIYNHVYFTDTHKCTIELTNFEGSMGKVLVKDSLDIPRSIALDPIEGWM 726

Human   153 YWTDWGEVPKIERAGMDGSSRFIIINSEIYWPNGLTLDYEEQKLYWADAKLNFIHKSNLDGTNRQ 217
            ||:|||..|:|||||||||.|..||:.::.||||:|||..::::||.|.|||.|..:|.||:.|.
  Fly   727 YWSDWGASPRIERAGMDGSHRTTIISYDVKWPNGITLDLVKKRIYWVDGKLNVISSANYDGSQRS 791

Human   218 AVVKGS--LPHPFALTLFEDILYWTDWSTHSILACNKYTGEGLREI---HSDIFSPMDIHAFSQQ 277
            .|:...  |.|||::|.|||.:|||||...::...||:|||.:..:   |. :..||.:|.:...
  Fly   792 QVLYSGEYLRHPFSITTFEDNVYWTDWDKQAVFKANKFTGEDVEPVTAMHM-LQHPMVVHVYHPY 855

Human   278 RQPNATNPCGIDNGGCSHLCLMSP----VKPFYQCACPTGVKLLENGKTCKDGATELLLL----- 333
            |||:..|.|...||.||||||.:|    ..|...||||||:||:.:|..|.:....|..:
  Fly   856 RQPDGVNHCQSVNGHCSHLCLPAPRINERSPRISCACPTGLKLMVDGLMCVEDPLYLPPVTRPPR 920

Human   334 ARRTDLR----RISLDT---PDFTDIVLQLED----------IRHAIAIDYDPVEGYIYWTDDEV 381
            ||:|..|    |..|.|   ....||.:::.|          :......|..||:.:   |..|.
  Fly   921 ARKTKPRPKSPRRRLPTGVQVGHADIRIEINDDLQLSTRLPLLPTTFVADQRPVKNH---TQIEK 982

Human   382 RAIRRSFIDGSGSQFVVTAQIAHPDGIAV 410
            ........|   |.|:....||...|.||
  Fly   983 TTTPSEQPD---SGFIALVVIASLSGFAV 1008

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LRP6	NP_002327.2	Beta-propeller 1	20..275		111/256 (43%)
		NHL	55..272	CDD:302697	99/221 (45%)
		NHL repeat	55..93	CDD:271320	13/37 (35%)
		LY	89..127	CDD:214531	13/37 (35%)
		NHL repeat	97..132	CDD:271320	15/34 (44%)
		NHL repeat	140..176	CDD:271320	25/35 (71%)
		Ldl_recept_b	150..190	CDD:278487	25/39 (64%)
		LY	175..216	CDD:214531	19/40 (48%)
		NHL repeat	181..217	CDD:271320	17/35 (49%)
		NHL repeat	226..253	CDD:271320	13/26 (50%)
		LDL-receptor class B 5	237..276		14/41 (34%)
		FXa_inhibition	286..323	CDD:291342	20/40 (50%)
		Beta-propeller 2	328..589		24/105 (23%)
		LY	353..393	CDD:214531	7/49 (14%)
		LY	397..437	CDD:214531	5/14 (36%)
		LY	438..481	CDD:214531
		LY	483..524	CDD:214531
		LY	525..558	CDD:214531
		FXa_inhibition	592..627	CDD:291342
		Beta-propeller 3	631..890
		LY	656..694	CDD:214531
		LY	697..739	CDD:214531
		LY	740..783	CDD:214531
		LY	783..825	CDD:214531
		LY	827..866	CDD:214531
		FXa_inhibition	893..929	CDD:291342
		Beta-propeller 4	933..1202
		LY	958..998	CDD:214531
		Ldl_recept_b	1069..1110	CDD:278487
		LY	1094..1136	CDD:214531
		FXa_inhibition	1207..1243	CDD:291342
		LDLa	1249..1285	CDD:238060
		LDLa	1288..1322	CDD:238060
		LDLa	1326..1360	CDD:238060
		PPPSP motif A	1487..1493
		PPPSP motif B	1527..1534
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1556..1613
		PPPSP motif C	1568..1575
		PPPSP motif D	1588..1593
		PPPSP motif E	1603..1610
LpR1	NP_001097934.2	LDLa	135..167	CDD:197566
		LDLa	178..210	CDD:197566
		LDLa	219..254	CDD:238060
		LDLa	259..295	CDD:238060
		LDLa	343..373	CDD:238060
		LDLa	383..415	CDD:197566
		Ldl_recept_a	423..459	CDD:278486
		LDLa	476..504	CDD:197566
		FXa_inhibition	514..549	CDD:291342
		EGF_CA	551..581	CDD:214542
		LY	662..702	CDD:214531	14/39 (36%)
		LY	704..747	CDD:214531	29/42 (69%)
		LY	749..790	CDD:214531	19/40 (48%)
		FXa_inhibition	864..905	CDD:291342	20/40 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910