Protein Alignment: LRP6 and LpR1

• Sequence 1: NP_002327.2
• Gene: LRP6
• HGNCID: 6698
• Length: 1613
• Species: Homo sapiens
• Sequence 2: NP_001097934.2
• Gene: LpR1
• FlyBaseID: FBgn0066101
• Length: 1076
• Species: Drosophila melanogaster
• Alignment Length: 419
• Identity: 160/420 (38%)
• Similarity: 226/420 (54%)
• Gaps: 40/420 (10%)

Human    23 LLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKRTEFNKTESVQ 87
            ||.|.|.|:|.: |.:..| .|.:|...:.|.|:||||..|:|:||||:.::|.:...::.....
  Fly   599 LLLARRHDIRKI-ALDHME-MTSIVNSTKAATALDFVFRTGMIFWSDVTTQSIYKAPIDEGNEKT 661

Human    88 NVVVSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQPRAIALDPSSGFM 152
            .|:....::.||||.||:...:|:||:....||::|.:||:.|||....||.||:|||||..|:|
  Fly   662 VVLTKSSVTSDGLAVDWIYNHVYFTDTHKCTIELTNFEGSMGKVLVKDSLDIPRSIALDPIEGWM 726

Human   153 YWTDWGEVPKIERAGMDGSSRFIIINSEIYWPNGLTLDYEEQKLYWADAKLNFIHKSNLDGTNRQ 217
            ||:|||..|:|||||||||.|..||:.::.||||:|||..::::||.|.|||.|..:|.||:.|.
  Fly   727 YWSDWGASPRIERAGMDGSHRTTIISYDVKWPNGITLDLVKKRIYWVDGKLNVISSANYDGSQRS 791

Human   218 AVVKGS--LPHPFALTLFEDILYWTDWSTHSILACNKYTGEGLREI---HSDIFSPMDIHAFSQQ 277
            .|:...  |.|||::|.|||.:|||||...::...||:|||.:..:   |. :..||.:|.:...
  Fly   792 QVLYSGEYLRHPFSITTFEDNVYWTDWDKQAVFKANKFTGEDVEPVTAMHM-LQHPMVVHVYHPY 855

Human   278 RQPNATNPCGIDNGGCSHLCLMSP----VKPFYQCACPTGVKLLENGKTCKDGATELLLL----- 333
            |||:..|.|...||.||||||.:|    ..|...||||||:||:.:|..|.:....|..:
  Fly   856 RQPDGVNHCQSVNGHCSHLCLPAPRINERSPRISCACPTGLKLMVDGLMCVEDPLYLPPVTRPPR 920

Human   334 ARRTDLR----RISLDT---PDFTDIVLQLED----------IRHAIAIDYDPVEGYIYWTDDEV 381
            ||:|..|    |..|.|   ....||.:::.|          :......|..||:.:   |..|.
  Fly   921 ARKTKPRPKSPRRRLPTGVQVGHADIRIEINDDLQLSTRLPLLPTTFVADQRPVKNH---TQIEK 982

Human   382 RAIRRSFIDGSGSQFVVTAQIAHPDGIAV 410
            ........|   |.|:....||...|.||
  Fly   983 TTTPSEQPD---SGFIALVVIASLSGFAV 1008

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LRP6	NP_002327.2	Beta-propeller 1	20..275		111/257 (43%)
		NHL	55..272	CDD:302697	99/222 (45%)
		NHL repeat	55..93	CDD:271320	13/38 (34%)
		LY	89..127	CDD:214531	14/38 (37%)
		NHL repeat	97..132	CDD:271320	16/35 (46%)
		NHL repeat	140..176	CDD:271320	25/36 (69%)
		Ldl_recept_b	150..190	CDD:278487	26/40 (65%)
		LY	175..216	CDD:214531	19/41 (46%)
		NHL repeat	181..217	CDD:271320	18/36 (50%)
		NHL repeat	226..253	CDD:271320	14/27 (52%)
		LDL-receptor class B 5	237..276		14/42 (33%)
		FXa_inhibition	286..323	CDD:291342	20/41 (49%)
		Beta-propeller 2	328..589		24/106 (23%)
		LY	353..393	CDD:214531	7/50 (14%)
		LY	397..437	CDD:214531	5/15 (33%)
		LY	438..481	CDD:214531
		LY	483..524	CDD:214531
		LY	525..558	CDD:214531
		FXa_inhibition	592..627	CDD:291342
		Beta-propeller 3	631..890
		LY	656..694	CDD:214531
		LY	697..739	CDD:214531
		LY	740..783	CDD:214531
		LY	783..825	CDD:214531
		LY	827..866	CDD:214531
		FXa_inhibition	893..929	CDD:291342
		Beta-propeller 4	933..1202
		LY	958..998	CDD:214531
		Ldl_recept_b	1069..1110	CDD:278487
		LY	1094..1136	CDD:214531
		FXa_inhibition	1207..1243	CDD:291342
		LDLa	1249..1285	CDD:238060
		LDLa	1288..1322	CDD:238060
		LDLa	1326..1360	CDD:238060
		PPPSP motif A	1487..1493
		PPPSP motif B	1527..1534
		PPPSP motif C	1568..1575
		PPPSP motif D	1588..1593
		PPPSP motif E	1603..1610
LpR1	NP_001097934.2	LDLa	135..167	CDD:197566
		LDLa	178..210	CDD:197566
		LDLa	219..254	CDD:238060
		LDLa	259..295	CDD:238060
		LDLa	343..373	CDD:238060
		LDLa	383..415	CDD:197566
		Ldl_recept_a	423..459	CDD:278486
		LDLa	476..504	CDD:197566
		FXa_inhibition	514..549	CDD:291342
		EGF_CA	551..581	CDD:214542
		LY	662..702	CDD:214531	15/40 (38%)
		LY	704..747	CDD:214531	29/43 (67%)
		LY	749..790	CDD:214531	19/41 (46%)
		FXa_inhibition	864..905	CDD:291342	20/41 (49%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100			O	PTHR24270
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100