Protein Alignment LRP6 and LpR1

DIOPT Version :10

• Sequence 1: NP_001401173.1
• Gene: LRP6 / 4040
• HGNCID: 6698
• Length: 1644
• Species: Homo sapiens
• Sequence 2: NP_001097934.2
• Gene: LpR1 / 2768687
• FlyBaseID: FBgn0066101
• Length: 1076
• Species: Drosophila melanogaster
• Alignment Length: 419
• Identity: 160/419 - (38%)
• Similarity: 226/419 - (53%)
• Gaps: 40/419 - (9%)

Human    23 LLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKRTEFNKTESVQ 87
            ||.|.|.|:|.: |.:..| .|.:|...:.|.|:||||..|:|:||||:.::|.:...::.....
  Fly   599 LLLARRHDIRKI-ALDHME-MTSIVNSTKAATALDFVFRTGMIFWSDVTTQSIYKAPIDEGNEKT 661

Human    88 NVVVSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQPRAIALDPSSGFM 152
            .|:....::.||||.||:...:|:||:....||::|.:||:.|||....||.||:|||||..|:|
  Fly   662 VVLTKSSVTSDGLAVDWIYNHVYFTDTHKCTIELTNFEGSMGKVLVKDSLDIPRSIALDPIEGWM 726

Human   153 YWTDWGEVPKIERAGMDGSSRFIIINSEIYWPNGLTLDYEEQKLYWADAKLNFIHKSNLDGTNRQ 217
            ||:|||..|:|||||||||.|..||:.::.||||:|||..::::||.|.|||.|..:|.||:.|.
  Fly   727 YWSDWGASPRIERAGMDGSHRTTIISYDVKWPNGITLDLVKKRIYWVDGKLNVISSANYDGSQRS 791

Human   218 AVVKGS--LPHPFALTLFEDILYWTDWSTHSILACNKYTGEGLREI---HSDIFSPMDIHAFSQQ 277
            .|:...  |.|||::|.|||.:|||||...::...||:|||.:..:   |. :..||.:|.:...
  Fly   792 QVLYSGEYLRHPFSITTFEDNVYWTDWDKQAVFKANKFTGEDVEPVTAMHM-LQHPMVVHVYHPY 855

Human   278 RQPNATNPCGIDNGGCSHLCLMSP----VKPFYQCACPTGVKLLENGKTCKDGATELLLL----- 333
            |||:..|.|...||.||||||.:|    ..|...||||||:||:.:|..|.:....|..:
  Fly   856 RQPDGVNHCQSVNGHCSHLCLPAPRINERSPRISCACPTGLKLMVDGLMCVEDPLYLPPVTRPPR 920

Human   334 ARRTDLR----RISLDT---PDFTDIVLQLED----------IRHAIAIDYDPVEGYIYWTDDEV 381
            ||:|..|    |..|.|   ....||.:::.|          :......|..||:.:   |..|.
  Fly   921 ARKTKPRPKSPRRRLPTGVQVGHADIRIEINDDLQLSTRLPLLPTTFVADQRPVKNH---TQIEK 982

Human   382 RAIRRSFIDGSGSQFVVTAQIAHPDGIAV 410
            ........|   |.|:....||...|.||
  Fly   983 TTTPSEQPD---SGFIALVVIASLSGFAV 1008

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LRP6	NP_001401173.1	YncE	1..204	CDD:442618	81/180 (45%)
		Beta-propeller 1	20..275		111/256 (43%)
		LY	89..127	CDD:214531	13/37 (35%)
		Ldl_recept_b	150..191	CDD:459654	26/40 (65%)
		LY	175..216	CDD:214531	19/40 (48%)
		LY	217..251	CDD:214531	14/35 (40%)
		LDL-receptor class B 5	237..276		14/41 (34%)
		FXa_inhibition	286..323	CDD:464251	20/40 (50%)
		Beta-propeller 2	328..589		24/105 (23%)
		LY	353..393	CDD:214531	7/49 (14%)
		LY	397..437	CDD:214531	5/14 (36%)
		Ldl_recept_b	458..499	CDD:459654
		LY	483..524	CDD:214531
		LY	525..558	CDD:214531
		FXa_inhibition	592..627	CDD:464251
		Beta-propeller 3	631..890
		YncE	<654..813	CDD:442618
		LY	697..739	CDD:214531
		LY	827..866	CDD:214531
		FXa_inhibition	893..929	CDD:464251
		LY	958..998	CDD:214531
		YncE	<968..1075	CDD:442618
		LY	1094..1132	CDD:214531
		FXa_inhibition	1238..1274	CDD:464251
		LDLa	1280..1316	CDD:238060
		LDLa	1319..1353	CDD:238060
		LDLa	1357..1391	CDD:238060
		PPPSP motif A	1518..1524
		PPPSP motif B	1558..1565
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1587..1644
		PPPSP motif C	1599..1606
		PPPSP motif D	1619..1624
		PPPSP motif E	1634..1641
LpR1	NP_001097934.2	LDLa	135..167	CDD:197566
		LDLa	178..210	CDD:197566
		LDLa	219..254	CDD:238060
		LDLa	259..295	CDD:238060
		LDLa	343..373	CDD:238060
		LDLa	383..415	CDD:197566
		Ldl_recept_a	423..459	CDD:395011
		LDLa	476..504	CDD:197566
		FXa_inhibition	514..549	CDD:464251
		EGF_CA	551..581	CDD:214542
		LY	662..702	CDD:214531	14/39 (36%)
		LY	704..747	CDD:214531	29/42 (69%)
		LY	749..790	CDD:214531	19/40 (48%)
		Ldl_recept_b	769..815	CDD:459654	20/45 (44%)
		FXa_inhibition	864..905	CDD:464251	20/40 (50%)