Protein Alignment TfAP-2 and TFAP2D

DIOPT Version :10

• Sequence 1: NP_001262178.1
• Gene: TfAP-2 / 40398
• FlyBaseID: FBgn0261953
• Length: 471
• Species: Drosophila melanogaster
• Sequence 2: NP_758438.2
• Gene: TFAP2D / 83741
• HGNCID: 15581
• Length: 452
• Species: Homo sapiens
• Alignment Length: 474
• Identity: 202/474 - (42%)
• Similarity: 264/474 - (55%)
• Gaps: 88/474 - (18%)

  Fly    21 RLSGHGSL-GLSSGSAAYT-----THSGGHTGRSGPATGHSGHSSTHGSAATMHHQSLQSDFQ-- 77
            ||...|.| .:::.:.||:     |:|...|..:.|      :.||:.....:||||...:||
Human    23 RLMQLGCLESVANSTVAYSSSSPLTYSTTGTEFASP------YFSTNHQYTPLHHQSFHYEFQHS 81

  Fly    78 -PPYFPPPF-----HHSTQSPPQQQISGYLQNHGALEYLGTDPYGQPLSSLHHAPLHHYNQLAG- 135
             |...|..:     |||.|.        |.|.|          :|:|...::   ||:...|..
Human    82 HPAVTPDAYSLNSLHHSQQY--------YQQIH----------HGEPTDFIN---LHNARALKSS 125

  Fly   136 -LRSTQDQLGIHRTHREAELQGHVTQLSHGFPY---TDRRSDYGSAISAGAAHGTRLGHEHESLA 196
             |...:.:||....:|..:|    :.:|||..|   .|:|...|.::...||
Human   126 CLDEQRRELGCLDAYRRHDL----SLMSHGSQYGMHPDQRLLPGPSLGLAAA------------- 173

  Fly   197 LHQALQNAVDDVQAPALDDNVAFMSDLPLIKSMKSGKEAGNIGSG-----SPSEVFCAVPGRLSL 256
                   ..||:|.     :|.....|.|      ..:.|.|..|     :|:::||:|||||||
Human   174 -------GADDLQG-----SVEAQCGLVL------NGQGGVIRRGGTCVVNPTDLFCSVPGRLSL 220

  Fly   257 LSSTSKYKVTIAEVQRRLSPPECLNASLLGGVLRRAKSKNGGRLLREKLEKIGLNLPAGRRKAAN 321
            ||||||||||||||:||||||||||||||||:|||||||||||.|||||:::|||||||||||||
Human   221 LSSTSKYKVTIAEVKRRLSPPECLNASLLGGILRRAKSKNGGRCLREKLDRLGLNLPAGRRKAAN 285

  Fly   322 VTLLTSLVEGEATHLAKDFHFVCETEFPARQLAEYIVRHQTEPQDSYRRKELILHSQQITKELMQ 386
            ||||||||||||.|||:||.:.|||||||:.:.|::.|...|.::...||::||.::||.||...
Human   286 VTLLTSLVEGEALHLARDFGYTCETEFPAKAVGEHLARQHMEQKEQTARKKMILATKQICKEFQD 350

  Fly   387 ILSQDRTTHFGTRSQHLLEPSMQRHLTHFSLITHGFGSPAIMAVLHAFQTFLNESLNYLEKLYPS 451
            :|||||:....:|...:|:..:|||||||||||||||:|||.|.|..|||.|:|.||||||....
Human   351 LLSQDRSPLGSSRPTPILDLDIQRHLTHFSLITHGFGTPAICAALSTFQTVLSEMLNYLEKHTTH 415

  Fly   452 NGGGMVSSSLDKSKIDNEK 470
            ..||...|.  :...::||
Human   416 KNGGAADSG--QGHANSEK 432

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TfAP-2	NP_001262178.1	TF_AP-2	247..441	CDD:460877	134/193 (69%)
TFAP2D	NP_758438.2	TF_AP-2	211..405	CDD:460877	134/193 (69%)
		H-S-H (helix-span-helix), dimerization. /evidence=ECO:0000255	280..410		76/129 (59%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	416..452		5/19 (26%)