Protein Alignment TfAP-2 and TFAP2E

DIOPT Version :10

• Sequence 1: NP_001262178.1
• Gene: TfAP-2 / 40398
• FlyBaseID: FBgn0261953
• Length: 471
• Species: Drosophila melanogaster
• Sequence 2: NP_848643.2
• Gene: TFAP2E / 339488
• HGNCID: 30774
• Length: 442
• Species: Homo sapiens
• Alignment Length: 466
• Identity: 213/466 - (45%)
• Similarity: 263/466 - (56%)
• Gaps: 79/466 - (16%)

  Fly    19 MERLSGHGSLGLSSGSAAYTTHSGGHTGRSGPATGHSGHSSTHGSAATMHHQSLQSDFQPPYFPP 83
            |||..|   ||.::|.|..::......|.:.|.        .|..|||     ..::||||||||
Human     9 MERPDG---LGAAAGGARLSSLPQAAYGPAPPL--------CHTPAAT-----AAAEFQPPYFPP 57

  Fly    84 PFHHSTQSP-PQQQISGYLQNHGALEYLGTDPYG--------QPLSSLHHAPLHHYNQLAGLRST 139
            |:   .|.| |..|..   ....|..:|..||||        ||..:...||      .|..|:.
Human    58 PY---PQPPLPYGQAP---DAAAAFPHLAGDPYGGLAPLAQPQPPQAAWAAP------RAAARAH 110

  Fly   140 QDQLGIHRTHREAELQGHVTQLSHGFPYTDRRSDYGSAIS------AGAAHG---TRLGHEHESL 195
            ::..|:        |......|.     .|.|.||.:|:.      |..|||   ..||  ...|
Human   111 EEPPGL--------LAPPARALG-----LDPRRDYATAVPRLLHGLADGAHGLADAPLG--LPGL 160

  Fly   196 ALHQALQN--AVDDVQAPALDDNV----------AFMSDLPLIKSMKSGKEAGNIGSGSPSEVFC 248
            |....|::  |:|:.....||.:|          :.:|.|.|.|....|      |..:|.||||
Human   161 AAAPGLEDLQAMDEPGMSLLDQSVIKKVPIPSKASSLSALSLAKDSLVG------GITNPGEVFC 219

  Fly   249 AVPGRLSLLSSTSKYKVTIAEVQRRLSPPECLNASLLGGVLRRAKSKNGGRLLREKLEKIGLNLP 313
            :|||||||||||||||||:.|||||||||||||||||||||||||||||||.|||:|||||||||
Human   220 SVPGRLSLLSSTSKYKVTVGEVQRRLSPPECLNASLLGGVLRRAKSKNGGRCLRERLEKIGLNLP 284

  Fly   314 AGRRKAANVTLLTSLVEGEATHLAKDFHFVCETEFPARQLAEYIVRHQTEPQDSYRRKELILHSQ 378
            ||||||||||||||||||||.|||:||.:||||||||:..|||:.|...:|.:.:.||.::|.::
Human   285 AGRRKAANVTLLTSLVEGEAVHLARDFGYVCETEFPAKAAAEYLCRQHADPGELHSRKSMLLAAK 349

  Fly   379 QITKELMQILSQDRTTHFGTRSQHLLEPSMQRHLTHFSLITHGFGSPAIMAVLHAFQTFLNESLN 443
            ||.||...:::|||:....:|...:|||.:|..||||||||||||.|||.|.|.|||.:|.|||.
Human   350 QICKEFADLMAQDRSPLGNSRPALILEPGVQSCLTHFSLITHGFGGPAICAALTAFQNYLLESLK 414

  Fly   444 YLEKLYPSNGG 454
            .|:|::.|:.|
Human   415 GLDKMFLSSVG 425

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TfAP-2	NP_001262178.1	TF_AP-2	247..441	CDD:460877	136/193 (70%)
TFAP2E	NP_848643.2	PPxY motif. /evidence=ECO:0000255	54..59		4/4 (100%)
		TF_AP-2	218..412	CDD:460877	136/193 (70%)
		H-S-H (helix-span-helix), dimerization. /evidence=ECO:0000255	287..417		75/129 (58%)