DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Alp1 and Alpi

DIOPT Version :9

Sequence 1:	NP_001262159.1	Gene:	Alp1 / 40372	FlyBaseID:	FBgn0283479	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_001074551.1	Gene:	Alpi / 76768	MGIID:	1924018	Length:	554	Species:	Mus musculus

Alignment Length:	506	Identity:	223/506 - (44%)
Similarity:	290/506 - (57%)	Gaps:	35/506 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 SELKSKEFWFHDAQRTLYNKLSTPPNQYRAKNVIFFLGDGMSVPTVTAGRIFDGQLRGVVGERNR 99
            :|.::..||...|...|.......|.|..|||:|.||||||.||||||.||..|||.|.:|....
Mouse    24 AEEENPAFWNKKAAEALDAAKKLQPIQTSAKNLIIFLGDGMGVPTVTATRILKGQLEGHLGPETP 88

  Fly   100 LEFEKFNYVGLSKTYCVNKQVADSACTASAYLSGIKANYLTIGVTADVELNDCRGSRLPQNRLSS 164
            |..:.|.|:.|||||.|::||.|||.||:|||.|:||||.|||::|...|:.|..:.  .|.:.|
Mouse    89 LAMDLFPYMALSKTYNVDRQVPDSAGTATAYLCGVKANYKTIGLSAAARLDQCNTTF--GNEVFS 151

  Fly   165 IAAWALKGSKSAGLVTTTRVTHASPAGVYAHTSNRDFESDYDVTKLGQNPGNCPDIAQQLIDG-D 228
            :...|.|..||.|:||||||.||||||.||||.||::.||.::.......| |.|||.|||.. |
Mouse   152 VMYRAKKAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDAEMPASALQDG-CKDIATQLISNMD 215

  Fly   229 VGKRLRVVMGGGTIKFLPNTTNDV-----FGNKGQRLDNRNLIEEWQQTKPGNARVVFSRTDLL- 287
            :.    |::|||.....|..|.|.     ....|.|||::||::.|.....| ||.|::|::|:
Mouse   216 ID----VILGGGRKFMFPKGTPDPEYPSDSNQSGTRLDDQNLVQTWLSKHQG-ARYVWNRSELIQ 275

  Fly   288 -NNDAQNTDFLLGLFNASHLAY--HMDDSIDTPTLPEMTAAAINVLSRDPNGYFLFVEGGRIDHA 349
             :.|...| .|:|||..:.:.|  :.:.|:| |:|.|||..|:.:|||:|.|::|||||||||..
Mouse   276 ASQDPAVT-HLMGLFEPTEMKYDANRNPSVD-PSLAEMTEVAVRMLSRNPQGFYLFVEGGRIDQG 338

  Fly   350 HHETKAKKALDETVQFSDAVRKARQLTNPWDTLIVVSADHGHTVTISGYPDVNNSIVGLNSELSN 414
            ||...|..||.|.|.|..|:.||.||||..||||:::|||.|.....||.....||.|| :.|..
Mouse   339 HHAGTAYLALTEAVMFDSAIEKASQLTNEKDTLILITADHSHVFAFGGYTLRGTSIFGL-APLKA 402

  Fly   415 VDQLPYTSISYANGPAYERFYKSTDGVVERVDLRNLDFSKPDAIYPHGVPMTEETHGGGDVAVYA 479
            :|...||||.|.|||.||....:...|.|   .:::|   |:......||::.|||||.|||::|
Mouse   403 LDDKSYTSILYGNGPGYELKSGNRPNVTE---AQSVD---PNYKQQAAVPLSSETHGGEDVAIFA 461

  Fly   480 HVVEYLLQGPWSHLFTGVYEQSTLPHLMGFASCLGPGITYCDLQPKARYSP 530
                   :||.:||..||.||:.:.|:|.||.||.| .|.|.|.|.|..||
Mouse   462 -------RGPQAHLVHGVQEQNYIAHVMAFAGCLEP-YTDCGLAPPAGQSP 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alp1	NP_001262159.1	alkPPc	65..514	CDD:214515	206/458 (45%)
Alpi	NP_001074551.1	Alk_phosphatase	53..488	CDD:278666	206/458 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847900
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1785
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48882
OrthoDB	1	1.010	-	-		D216917at33208
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	1	1.000	-	-		mtm8903
orthoMCL	1	0.900	-	-		OOG6_100381
Panther	1	1.100	-	-	O	PTHR11596
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X159
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.760