Protein Alignment Pc and CBX7

DIOPT Version :10

• Sequence 1: NP_524199.1
• Gene: Pc / 40358
• FlyBaseID: FBgn0003042
• Length: 390
• Species: Drosophila melanogaster
• Sequence 2: NP_783640.1
• Gene: CBX7 / 23492
• HGNCID: 1557
• Length: 251
• Species: Homo sapiens
• Alignment Length: 387
• Identity: 98/387 - (25%)
• Similarity: 128/387 - (33%)
• Gaps: 174/387 - (44%)

  Fly    25 VYAAEKIIQKRVKKGVVEYRVKWKGWNQRYNTWEPEVNILDRRLIDIYEQTNKSSGTPSKRGIKK 89
            |:|.|.|.:|||:||.|||.||||||..:|:|||||.:|||.||:..||
Human    10 VFAVESIRKKRVRKGKVEYLVKWKGWPPKYSTWEPEEHILDPRLVMAYE---------------- 58

  Fly    90 KEKEPDPEPESEEDEYTFTENDVDTHQATTSSATHDKESKKEKKHHHHHHHHHHIKSERNSGRRS 154
             |||                                                   :.:|.||.|.
Human    59 -EKE---------------------------------------------------ERDRASGYRK 71

  Fly   155 ESPLTHHHHHHHHESKRQRIDHSSSSNSSFTH----------------NSFVPEPDSNSSSSE-- 201
            ..|          :.||..:....|.:...:|                .|..||....:.:.|
Human    72 RGP----------KPKRLLLQRLYSMDLRSSHKAKGKEKLCFSLTCPLGSGSPEGVVKAGAPELV 126

  Fly   202 DQ-PLIGT-------KRKA-EVLKESGKIGVTIKTSPDGPTIKPQPTQQVTPSQQQPFQDQQQAE 257
            |: ||:.|       .||| :.|:.|.|     |..|.||.::....::....|:.|..|..||
Human   127 DKGPLVPTLPFPLRKPRKAHKYLRLSRK-----KFPPRGPNLESHSHRRELFLQEPPAPDVLQA- 185

  Fly   258 KIASEAATQLKSEQQATPLATEAINTTPAESGAEEEEVAN-EEGNQQAPQVPSENNNIPKPCNNL 321
                                  |....||....|||..|: .||
Human   186 ----------------------AGEWEPAAQPPEEEADADLAEG--------------------- 207

  Fly   322 AINQKQPLTPLSPRALPPRFWLPAKCNISNRVVITDVTVNLETVTIRECKTERGFFRERDMK 383
                ..|.||    |||           |:.|.:||:|.|..|||.||.:...||||:|..|
Human   208 ----PPPWTP----ALP-----------SSEVTVTDITANSITVTFREAQAAEGFFRDRSGK 250

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pc	NP_524199.1	CD_polycomb	23..76	CDD:349291	31/50 (62%)
		CBX7_C	341..373	CDD:465385	11/31 (35%)
CBX7	NP_783640.1	CD_Cbx7	7..62	CDD:349293	34/119 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	190..220		15/69 (22%)
		CBX7_C	209..240	CDD:465385	17/45 (38%)
		Required for cellular lifespan extension	223..236		7/12 (58%)