Protein Alignment AcCoAS and ACSS1

DIOPT Version :10

• Sequence 1: NP_730611.1
• Gene: AcCoAS / 40348
• FlyBaseID: FBgn0012034
• Length: 670
• Species: Drosophila melanogaster
• Sequence 2: NP_115890.2
• Gene: ACSS1 / 84532
• HGNCID: 16091
• Length: 689
• Species: Homo sapiens
• Alignment Length: 663
• Identity: 304/663 - (45%)
• Similarity: 415/663 - (62%)
• Gaps: 43/663 - (6%)

  Fly    12 PAISQNAYISSFEEYQKFYQESLDNPAEFWSRVAKQ-FHWETPADQDKFLKYNFNISKGPISIKW 75
            ||::  |..:....|.....::...||.||..:|:. ..|:||    ....::.:.|.|.|.  |
Human    46 PAVA--AAAAQPGSYPALSAQAAREPAAFWGPLARDTLVWDTP----YHTVWDCDFSTGKIG--W 102

  Fly    76 MEGASTNLCYNLLDRNVRNGLGDQIAYYWEGNHPDDYSRGLTYRKLLEEVCRFANVLKDHGIRKG 140
            ..|...|:..|.||::||.. .:.:|..||.:.|....| :|||:|||..||.||.||.||:.:|
Human   103 FLGGQLNVSVNCLDQHVRKS-PESVALIWERDEPGTEVR-ITYRELLETTCRLANTLKRHGVHRG 165

  Fly   141 DRVSIYMPMILELPIAMLACARIGAVHSIVFAGFSPDSLAERMFDCKAKLLITADGAWRGEKPLY 205
            |||:||||:......||||||||||||:::|||||.:|||.|:.|.|.|::||.:...||.:.:.
Human   166 DRVAIYMPVSPLAVAAMLACARIGAVHTVIFAGFSAESLAGRINDAKCKVVITFNQGLRGGRVVE 230

  Fly   206 LKALCDTALEKVEEMGHSVEKCIVVSHLKRVTPCQPDHVEEEIPWTD------DRDYWWHEEMED 264
            ||.:.|.|::....:.|     ::|:|.                 ||      |.|....:||..
Human   231 LKKIVDEAVKHCPTVQH-----VLVAHR-----------------TDNKVHMGDLDVPLEQEMAK 273

  Fly   265 KEPACYPEWMDAEDPLFMLYTSGSTGKPKGVLHTTAGYLLYAATTFKIVFDYKPGDIYWCTGDVG 329
            ::|.|.||.|.:||.|||||||||||.|||::||.||||||||.|.|:|||::||||:.|..|:|
Human   274 EDPVCAPESMGSEDMLFMLYTSGSTGMPKGIVHTQAGYLLYAALTHKLVFDHQPGDIFGCVADIG 338

  Fly   330 WITGHTYVVYGPLANGATSVIFEGTPFFPGNDRYWSVIDKYKVTQFYTAPTAIRALMKFGEGPVL 394
            |||||:|||||||.||||||:||.||.:|...|||..:::.|:.|||.||||:|.|:|:|:..|.
Human   339 WITGHSYVVYGPLCNGATSVLFESTPVYPNAGRYWETVERLKINQFYGAPTAVRLLLKYGDAWVK 403

  Fly   395 KHNLSGLKVLGSVGEPINPEAWLWYYKYIGKEQCSIVDTFWQTETGGHVITPLPG--ATPMKPGS 457
            |::.|.|:.|||||||||.|||.|.::.:|..:|::|||:|||||||..|.|.|.  ...:.|..
Human   404 KYDRSSLRTLGSVGEPINCEAWEWLHRVVGDSRCTLVDTWWQTETGGICIAPRPSEEGAEILPAM 468

  Fly   458 ASFPFFGVKPTLLDECGIEIKGEG-EGYLVFSQPWPGMMRTLYNNHERFEDTYFSKFPGYYCTGD 521
            |..||||:.|.|:||.|..::|.. .|.|..||.||||.||:|.:|:||.|.||..:||||.|||
Human   469 AMRPFFGIVPVLMDEKGSVVEGSNVSGALCISQAWPGMARTIYGDHQRFVDAYFKAYPGYYFTGD 533

  Fly   522 GARRDADGYLWITGRVDDMLNVSGHLMSTAEVESVLTEHPRVAESAVVSRPHPVKGECLYCFITP 586
            ||.|...||..||||:||::|:|||.:.|||:|..:.:||.|.||||:..||.:|||..:.||..
Human   534 GAYRTEGGYYQITGRMDDVINISGHRLGTAEIEDAIADHPAVPESAVIGYPHDIKGEAAFAFIVV 598

  Fly   587 NENEVFDQKLISDLKKMVRERIGPFAMPDVIQNAPGLPKTRSGKIMRRVLRKIAVND-RNVGDTS 650
            .::......::.:||.||..:|..:|:||.|.....||||||||:|||:||||..:: :.:|||:
Human   599 KDSAGDSDVVVQELKSMVATKIAKYAVPDEILVVKRLPKTRSGKVMRRLLRKIITSEAQELGDTT 663

  Fly   651 TLADEQIVEQLFA 663
            ||.|..|:.::.:
Human   664 TLEDPSIIAEILS 676

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AcCoAS	NP_730611.1	ACS	24..654	CDD:341270	299/640 (47%)
ACSS1	NP_115890.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	17..46		304/663 (46%)
		Ac_CoA_lig_AcsA	54..676	CDD:274022	301/651 (46%)