Protein Alignment AcCoAS and ACSS3

DIOPT Version :10

• Sequence 1: NP_730611.1
• Gene: AcCoAS / 40348
• FlyBaseID: FBgn0012034
• Length: 670
• Species: Drosophila melanogaster
• Sequence 2: NP_078836.1
• Gene: ACSS3 / 79611
• HGNCID: 24723
• Length: 686
• Species: Homo sapiens
• Alignment Length: 659
• Identity: 238/659 - (36%)
• Similarity: 359/659 - (54%)
• Gaps: 53/659 - (8%)

  Fly    22 SFEEYQKFYQESLDNPAEFWSRVAKQFHWETPADQDKFLKYNFNISKGPISIKWMEGASTNLCYN 86
            |..||:..:..|:.:|..||.:.|:|..|..|  ..|.|:     :|...|.:|......|:|||
Human    58 SGSEYKTHFAASVTDPERFWGKAAEQISWYKP--WTKTLE-----NKHSPSTRWFVEGMLNICYN 115

  Fly    87 LLDRNVRNGLGDQIAYYWEGNHPDDYSRG-LTYRKLLEEVCRFANVLKDHGIRKGDRVSIYMPMI 150
            .:||::.||.||:||..::.  |...::. .||:::||:|.:.|.||..|||:|||.|.||||||
Human   116 AVDRHIENGKGDKIAIIYDS--PVTNTKATFTYKEVLEQVSKLAGVLVKHGIKKGDTVVIYMPMI 178

  Fly   151 LELPIAMLACARIGAVHSIVFAGFSPDSLAERMFDCKAKLLITAD-GAWRGEKPLYLKALCDTAL 214
            .:....|||||||||:||::|.||:...|:.|:...|.|:::||. |...|.:..|: .|.:.||
Human   179 PQAMYTMLACARIGAIHSLIFGGFASKELSSRIDHVKPKVVVTASFGIEPGRRVEYV-PLVEEAL 242

  Fly   215 EKVEEMGHSVEKCIVVSHLKRVTPCQPDHVEEEIPWTDDRDYWWHEEM-EDKEPACYPEWMDAED 278
             |:.:  |..:|.::.:        :|:  .|.:|....||..|.||| :.:...|.|  :.:|.
Human   243 -KIGQ--HKPDKILIYN--------RPN--MEAVPLAPGRDLDWDEEMAKAQSHDCVP--VLSEH 292

  Fly   279 PLFMLYTSGSTGKPKGVLHTTAGYLLYAATTFKIVFDYKPGDIYWCTGDVGWITGHTYVVYGPLA 343
            ||::|||||:||.||||:..|.||.:....:...::..:||:::|...|:||:.||:|:.||||.
Human   293 PLYILYTSGTTGLPKGVIRPTGGYAVMLHWSMSSIYGLQPGEVWWAASDLGWVVGHSYICYGPLL 357

  Fly   344 NGATSVIFEGTPF-FPGNDRYWSVIDKYKVTQFYTAPTAIRALMKFGEGPVL--KHNLSGLKVLG 405
            :|.|:|::||.|. .|....|:.|:.::.|...:||||||||:.:...|..|  :::|:..|.|.
Human   358 HGNTTVLYEGKPVGTPDAGAYFRVLAEHGVAALFTAPTAIRAIRQQDPGAALGKQYSLTRFKTLF 422

  Fly   406 SVGEPINPEAWLWYYKYIGKEQCSIVDTFWQTETGGHVITPLPG----ATPMKPGSASFPFFGVK 466
            ..||..:.|...|.....   :..::|.:||||||..:.....|    .|| .||.|.....|..
Human   423 VAGERCDVETLEWSKNVF---RVPVLDHWWQTETGSPITASCVGLGNSKTP-PPGQAGKSVPGYN 483

  Fly   467 PTLLDECGIEIKGEGEGYLVFSQPW-PGMMRTLYNNHERFEDTYFSKFPGYYCTGDGARRDADGY 530
            ..:||:...::|....|.:|...|. ||....|:.|.|.|:..||.||||||.|.|....|.:||
Human   484 VMILDDNMQKLKARCLGNIVVKLPLPPGAFSGLWKNQEAFKHLYFEKFPGYYDTMDAGYMDEEGY 548

  Fly   531 LWITGRVDDMLNVSGHLMSTAEVESVLTEHPRVAESAVVSRPHPVKGE--CLYCFITPNENEVFD 593
            |::..||||::||:||.:|...:|..:..|..||:.|||.:..|:||.  ...|.:..:.|.. :
Human   549 LYVMSRVDDVINVAGHRISAGAIEESILSHGTVADCAVVGKEDPLKGHVPLALCVLRKDINAT-E 612

  Fly   594 QKLISDLKKMVRERIGPFAMPDVIQNA---PGLPKTRSGKIMRRVLRKIAVNDRNVGDTSTLADE 655
            ::::.::.|.||:.|||.|   ..:||   ..|||||||||.|..|..| ||.:....|||:.|.
Human   613 EQVLEEIVKHVRQNIGPVA---AFRNAVFVKQLPKTRSGKIPRSALSAI-VNGKPYKITSTIEDP 673

  Fly   656 QI---VEQL 661
            .|   ||::
Human   674 SIFGHVEEM 682

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AcCoAS	NP_730611.1	ACS	24..654	CDD:341270	233/645 (36%)
ACSS3	NP_078836.1	PrpE	62..679	CDD:341271	234/650 (36%)