Protein Alignment AcCoAS and ACSM2B

DIOPT Version :10

• Sequence 1: NP_730611.1
• Gene: AcCoAS / 40348
• FlyBaseID: FBgn0012034
• Length: 670
• Species: Drosophila melanogaster
• Sequence 2: NP_872423.3
• Gene: ACSM2B / 348158
• HGNCID: 30931
• Length: 577
• Species: Homo sapiens
• Alignment Length: 669
• Identity: 164/669 - (24%)
• Similarity: 268/669 - (40%)
• Gaps: 170/669 - (25%)

  Fly    15 SQNAYISSFE--EYQKFYQESLDNPAEFWSRVAKQFHWETPADQDKFLKYNFNISKGPI-SIKWM 76
            |:..||:|.:  ..|..:||.   ||:|........||   ||.:|..|      :.|. ::.|:
Human    20 SRTLYINSRQLVSLQWGHQEV---PAKFNFASDVLDHW---ADMEKAGK------RLPSPALWWV 72

  Fly    77 EGASTNLCYNLLDRNVRNGLGDQIAYYWEGNHPDDYSRGLTYRKLLEEVCRFANVLKDH-GIRKG 140
            .|....|.:|                               :|:|.|...:.||:|... |:::|
Human    73 NGKGKELMWN-------------------------------FRELSENSQQAANILSGACGLQRG 106

  Fly   141 DRVSIYMPMILELPIAMLACARIGAVHSIVFAGFSPDSLAERMFD-------CKAKLLITADGAW 198
            |||::.:|.:.|..:.:|.|.|.|.:       |.|.::..:..|       .|||.::..|
Human   107 DRVAVMLPRVPEWWLVILGCIRAGLI-------FMPGTIQMKSTDILYRLQMSKAKAIVAGD--- 161

  Fly   199 RGEKPLYLKALCDTALEKVEEMGHSVEKC--IVVSHLKRVTPCQPDHVEEEIPWTDDRDYWWHEE 261
                            |.::|:.....:|  :.:..|.....|               |.|.:.:
Human   162 ----------------EVIQEVDTVASECPSLRIKLLVSEKSC---------------DGWLNFK 195

  Fly   262 MEDKEPACYPEWMD--AEDPLFMLYTSGSTGKPKGVLHTTAGYLLYAATTFKIVFD-----YKPG 319
            ....|.:.....::  :::...:.:|||::|.||...|:      |::...|...|     .:..
Human   196 KLLNEASTTHHCVETGSQEASAIYFTSGTSGLPKMAEHS------YSSLGLKAKMDAGWTGLQAS 254

  Fly   320 DIYWCTGDVGWITGHTYVVYGPLAN----GATSVIFEGTPFFPGNDRYWSVIDK----YKVTQFY 376
            ||.|...|.|||..    :.|.|..    ||.:.:.....|.|      .||.|    |.:....
Human   255 DIMWTISDTGWILN----ILGSLLESWTLGACTFVHLLPKFDP------LVILKTLSSYPIKSMM 309

  Fly   377 TAPTAIRALM-------KFGEGPVLKHNLSGLKVLGSVGEPINPEAWLWYYKYIGKEQCSIVDTF 434
            .||...|.|:       ||   |.|::.|:|       ||.:.||....:....|.:   |.:.:
Human   310 GAPIVYRMLLQQDLSSYKF---PHLQNCLAG-------GESLLPETLENWRAQTGLD---IREFY 361

  Fly   435 WQTETGGHVITPLPGAT-PMKPGSASFPFFGVKPTLLDECGIEIKG-------EGEGYLVFSQPW 491
            .|||||   :|.:...| .:|||     :.|...:..|...|:.||       ||:   :..:..
Human   362 GQTETG---LTCMVSKTMKIKPG-----YMGTAASCYDVQVIDDKGNVLPPGTEGD---IGIRVK 415

  Fly   492 PGMMRTLYNNHERFEDTYFSKFPG-YYCTGDGARRDADGYLWITGRVDDMLNVSGHLMSTAEVES 555
            |.....:::.:....|...:...| ::..||...:|.|||....||.||::|.||:.:..:|||:
Human   416 PIRPIGIFSGYVENPDKTAANIRGDFWLLGDRGIKDEDGYFQFMGRADDIINSSGYRIGPSEVEN 480

  Fly   556 VLTEHPRVAESAVVSRPHPVKGECLYCF-ITPNENEVFD-QKLISDLKKMVRERIGPFAMPDVIQ 618
            .|.:||.|.|:||:|.|.||:||.:..| |..::....| ::|..:|::.|:....|:..|..|:
Human   481 ALMKHPAVVETAVISSPDPVRGEVVKAFVILASQFLSHDPEQLTKELQQHVKSVTAPYKYPRKIE 545

  Fly   619 NAPGLPKTRSGKIMRRVLR 637
            ....||||.:|||.|..||
Human   546 FVLNLPKTVTGKIQRTKLR 564

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AcCoAS	NP_730611.1	ACS	24..654	CDD:341270	160/660 (24%)
ACSM2B	NP_872423.3	Adenylate forming domain, Class I superfamily	40..568	CDD:473059	157/649 (24%)