Protein Alignment AcCoAS and Acsm3

DIOPT Version :10

• Sequence 1: NP_730611.1
• Gene: AcCoAS / 40348
• FlyBaseID: FBgn0012034
• Length: 670
• Species: Drosophila melanogaster
• Sequence 2: XP_017177549.1
• Gene: Acsm3 / 20216
• MGIID: 99538
• Length: 593
• Species: Mus musculus
• Alignment Length: 622
• Identity: 178/622 - (28%)
• Similarity: 269/622 - (43%)
• Gaps: 103/622 - (16%)

  Fly    23 FEEYQKFYQESLDNPAEFWSRVAKQFHWETPADQDKFLKYNFNISKGPISIKW--MEGAS---TN 82
            :::|:....::..|    :..:.:.|..|.|       :| ||.:|..:. :|  ||.|.   :|
Mouse    23 YKDYRTATPQNFSN----YESMKQDFKIEIP-------EY-FNFAKDVLD-QWTNMEKAGKRLSN 74

  Fly    83 LCYNLLDRNVRNGLGDQIAYYWEGNHPDDYSRGLTYRKLLEEVCRFANVLKDH-GIRKGDRVSIY 146
            ..:..:|.|     |:::.:.:|       ..||..||       |||:|.:. .:::||||.:.
Mouse    75 PAFWWIDGN-----GEELRWSFE-------ELGLLSRK-------FANILTEACSLQRGDRVMVI 120

  Fly   147 MPMILELPIAMLACARIGAVHSIVFAGFSPDSLAERMFDCKAKLLITADGAWRGEKPLYLKALCD 211
            :|.|.|..:|.:||.|.|.|........:...:..|:...|||.:||.|         .|....|
Mouse   121 LPKIPEWWLANVACLRTGTVLIPGTTQLTQKDILYRLQSSKAKCIITDD---------TLAPAVD 176

  Fly   212 TALEKVEEMGHSVEKCIVVSHLKRVTPCQPDHVEEEIPWTDDRDYWWHEEMEDKEPACYPEWMDA 276
            ....|.|.: ||  |.||..|.:...    .:::|.:.:..|.    |..::.|.
Mouse   177 AVAAKCENL-HS--KLIVSQHSREGW----GNLKEMMKYASDS----HTCVDTKH---------- 220

  Fly   277 EDPLFMLYTSGSTGKPKGVLHTTAGYLLYAATTFKIVFDYKPGDIYWCTGDVGWITGHTYVVYGP 341
            ::.:.:.:|||:||.||.:.||.:.:.|..:...:...|....|:.|.|.|.||.......|:.|
Mouse   221 DEMMAIYFTSGTTGPPKMIGHTHSSFGLGLSVNGRFWLDLIASDVMWNTSDTGWAKSAWSSVFSP 285

  Fly   342 LANGATSVI-----FEGTPFFPGNDRYWSVIDKYKVTQFYTAPTAIRALMKFGEGPVLKHNLSGL 401
            ...||....     ||.|...       ..:.|:.:|.|.:||||.|.|::.......|.|  .|
Mouse   286 WTQGACVFAHYLPRFESTSIL-------QTLSKFPITVFCSAPTAYRMLVQNDMSRSYKFN--SL 341

  Fly   402 KVLGSVGEPINPEAWLWYYKYIGKEQCSIVDTFWQTETGGHVITPLPGATPMKPGSAS--FPFFG 464
            |...|.|||||||....:.|..|.:   |.:.:.||||  .:|........:||||..  .|.|.
Mouse   342 KHCVSAGEPINPEVMEQWRKKTGLD---IYEGYGQTET--VLICGNFKGMKIKPGSMGKPSPAFD 401

  Fly   465 VKPTLLDECGIEIKGEGEGYLVF----SQPWPGMMRTLYNNHERFEDTYFSKFPGYYCTGDGARR 525
            ||  :|||.|..:....||.:..    .:|: |:.....:|..:...|....|   |.|||....
Mouse   402 VK--ILDENGATLPPGQEGDIALQVLPERPF-GLFTHYVDNPSKTASTLRGSF---YITGDRGYM 460

  Fly   526 DADGYLWITGRVDDMLNVSGHLMSTAEVESVLTEHPRVAESAVVSRPHPVKGECLYCFITPN-EN 589
            |.|||.|...|.||::..||:.:...||||.|.|||.:|||||||.|.|::||.:..||..| :.
Mouse   461 DEDGYFWFVARSDDIILSSGYRIGPFEVESALIEHPSIAESAVVSSPDPIRGEVVKAFIVLNPDY 525

  Fly   590 EVFDQKLISDLKKMVRERIGPFAMPDVIQNAPGLPKT 626
            :..||:   .|||.::|.:.....|.......|:|.|
Mouse   526 KSHDQE---QLKKEIQEHVKKTTAPYKYPRKVGVPGT 559

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AcCoAS	NP_730611.1	ACS	24..654	CDD:341270	178/621 (29%)
Acsm3	XP_017177549.1	Adenylate forming domain, Class I superfamily	48..554	CDD:473059	171/586 (29%)