Protein Alignment AcCoAS and ACSM1

DIOPT Version :10

• Sequence 1: NP_730611.1
• Gene: AcCoAS / 40348
• FlyBaseID: FBgn0012034
• Length: 670
• Species: Drosophila melanogaster
• Sequence 2: NP_443188.2
• Gene: ACSM1 / 116285
• HGNCID: 18049
• Length: 577
• Species: Homo sapiens
• Alignment Length: 670
• Identity: 173/670 - (25%)
• Similarity: 260/670 - (38%)
• Gaps: 149/670 - (22%)

  Fly     5 KSIYDPNPAISQNAYISSFEEYQKFYQESLDNPAEFWSRVAKQFHWETPADQDKFLKYNFNISKG 69
            ||.::.:||.|| ....|..|:........:.|.||........:|.....:.|         :|
Human    15 KSFHNIHPAPSQ-LRCRSLSEFGAPRWNDYEVPEEFNFASYVLDYWAQKEKEGK---------RG 69

  Fly    70 PISIKWMEGASTNLCYNLLDRNVRNGLGDQIAYYWEGNHPDDYSRGLTYRKLLEEVCRFANVL-K 133
            |....|..                ||.||::.  |......|.:|            |.|||. :
Human    70 PNPAFWWV----------------NGQGDEVK--WSFREMGDLTR------------RVANVFTQ 104

  Fly   134 DHGIRKGDRVSIYMPMILELPIAMLACARIGAVHSIVFAGFSPDSLAERMFD-------CKAKLL 191
            ..|:::||.:::.:|.:.|..:..:.|.|.|.:       |.|.::..:..|       .|||.:
Human   105 TCGLQQGDHLALMLPRVPEWWLVAVGCMRTGII-------FIPATILLKAKDILYRLQLSKAKGI 162

  Fly   192 ITADGAWRGEKPLYLKALCDTALEKVEEMGHSVEKCIVVSHLKRVTPCQPDHVEEEIPWTDDRDY 256
            :|.|            ||. :.::.:.....|::..::||          ||..|  .|.|.|..
Human   163 VTID------------ALA-SEVDSIASQCPSLKTKLLVS----------DHSRE--GWLDFRSL 202

  Fly   257 WWHEEMEDKEPACYPEWMDAEDPLFMLYTSGSTGKPKGVLHTTAGYLLYAATTFKIVFDYKPGDI 321
               .:....|..|...  ...||:.:.:|||:||.||...|:....|..:....:.:...|..|:
Human   203 ---VKSASPEHTCVKS--KTLDPMVIFFTSGTTGFPKMAKHSHGLALQPSFPGSRKLRSLKTSDV 262

  Fly   322 YWCTGDVGWITGHTYVVYGPLANGA-----------TSVIFEGTPFFPGNDRYWSVIDKYK--VT 373
            .||..|.|||....:.:..|...|.           |.||.:....:|.| .:|.|...|:  :.
Human   263 SWCLSDSGWIVATIWTLVEPWTAGCTVFIHHLPQFDTKVIIQTLLKYPIN-HFWGVSSIYRMILQ 326

  Fly   374 QFYTAPTAIRALMKFGEGPVLKHNLSGLKVLGSVGEPINPEAW------LWYYKYIGKEQCSIVD 432
            |.:|:       ::|   |.|:|..:|    |.|..|.:.|.|      |.|..|...|...|..
Human   327 QDFTS-------IRF---PALEHCYTG----GEVVLPKDQEEWKRRTGLLLYENYGQSETGLICA 377

  Fly   433 TFWQTETGGHVITPLPGATPMKPGSASFPFFGVKPTLLDECGIEIKG-------EGEGYLVFSQP 490
            |:|              ...:|||     |.|......|...|:.||       ||...:.....
Human   378 TYW--------------GMKIKPG-----FMGKATPPYDVQVIDDKGSILPPNTEGNIGIRIKPV 423

  Fly   491 WPGMMRTLYNNHERFEDTYFSKFPGYYCTGDGARRDADGYLWITGRVDDMLNVSGHLMSTAEVES 555
            .|..:...|....  |.|...:...:|.|||..:.|.:||:...||.||::|.||:.:..|||||
Human   424 RPVSLFMCYEGDP--EKTAKVECGDFYNTGDRGKMDEEGYICFLGRSDDIINASGYRIGPAEVES 486

  Fly   556 VLTEHPRVAESAVVSRPHPVKGECLYCFI--TPNENEVFDQKLISDLKKMVRERIGPFAMPDVIQ 618
            .|.|||.|||||||..|.|::||.:..||  ||........:|..:|::.|:....|:..|..::
Human   487 ALVEHPAVAESAVVGSPDPIRGEVVKAFIVLTPQFLSHDKDQLTKELQQHVKSVTAPYKYPRKVE 551

  Fly   619 NAPGLPKTRSGKIMRRVLRK 638
            ....||||.:|||.|:.|||
Human   552 FVSELPKTITGKIERKELRK 571

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AcCoAS	NP_730611.1	ACS	24..654	CDD:341270	166/651 (25%)
ACSM1	NP_443188.2	MACS_euk	45..574	CDD:341251	165/639 (26%)