DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG10508 and WWC2

DIOPT Version :10

Sequence 1:NP_001246859.1 Gene:CG10508 / 40342 FlyBaseID:FBgn0037060 Length:733 Species:Drosophila melanogaster
Sequence 2:NP_001397793.1 Gene:WWC2 / 80014 HGNCID:24148 Length:1216 Species:Homo sapiens


Alignment Length:694 Identity:141/694 - (20%)
Similarity:241/694 - (34%) Gaps:156/694 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 KMPPGWDCKYDQATGNCYYINYLTKAMQLEDP----RGRSYRQLQNERCSTESIALQQLVSQPQT 69
            ::|.||:..:|...| .|||:::.|..|:|||    ||...:.|::..    |:|...|.:|.:.
Human    58 ELPWGWEAGFDPQIG-VYYIDHINKTTQIEDPRKQWRGEQEKMLKDYL----SVAQDALRTQKEL 117

  Fly    70 SHNSSPYHVHPSNNLTAI-------RAFQERQQPTLHNISTSPLLSASSRG--------HLEMSS 119
                  |||.......|:       .|::|:..      |.:.|.|.||..        ..|:|:
Human   118 ------YHVKEQRLALALDEYVRLNDAYKEKSS------SHTSLFSGSSSSTKYDPDILKAEIST 170

  Fly   120 PLPFQRARVG------PNLSRRSTIQETSFTTQAETDAVVTKIQNMFPTAGENHIRLLLKRYYNS 178
                .|.||.      ..:.:....:|..|.|..:.|..::..|:.:..:....|...||    |
Human   171 ----TRLRVKKLKRELSQMKQELLYKEQGFETLQQIDKKMSGGQSGYELSEAKAILTELK----S 227

  Fly   179 EAVVVSALQVEKHPVTMPGPFVTPPSQRHLFHSGSAFYMTPPARRPDTV-----ASRRTSRTASP 238
            ....:|:.:.||..:..     :....:..||.......:.|..|...|     .||:|...   
Human   228 IRKAISSGEKEKQDLMQ-----SLAKLQERFHLDQNIGRSEPDLRCSPVNSHLCLSRQTLDA--- 284

  Fly   239 LPGGRFGSLVSVQSGPGGPSGHQAVLPPSSAVPPALHGSPLWRSSPRPHSSPKMKLRYM-KNIFP 302
                  ||..|:....|..|        .|.:...:..|..:..:.|..::.|::|..: ...:|
Human   285 ------GSQTSISGDIGVRS--------RSNLAEKVRLSLQYEEAKRSMANLKIELSKLDSEAWP 335

  Fly   303 KA-------------DEELLLDI------------LANADNNVQFASEKLISL-GYTKRDMQQPH 341
            .|             .||||.::            |...:...|...|:|:|: |...|.:.:..
Human   336 GALDIEKEKLMLINEKEELLKELQFVTPQKRTQDELERLEAERQRLEEELLSVRGTPSRALAERL 400

  Fly   342 RPNNRPPDLNQDQEAGGDQSGVHIPLRPKEYTEEEKTKMQTLLKEKYPQIAERIILMALESVNYA 406
            |...|..:|.|..                    ||.||:.|.|..:         |.:|.:...:
Human   401 RLEERRKELLQKL--------------------EETTKLTTYLHSQ---------LKSLSASTLS 436

  Fly   407 EDRATQILQIVQDEDEQREQKQAPMNP-KHLDLKKTTGTEQIDGANEKDSLPAVVEPTTSSKPKP 470
            ....:.:..:...........:..:|. ...:|..::.::||| .:.:..|..:::..:...|..
Human   437 MSSGSSLGSLASSRGSLNTSSRGSLNSLSSTELYYSSQSDQID-VDYQYKLDFLLQEKSGYIPSG 500

  Fly   471 P----HKRHILPSINVTTPSTFTTQIILAQATPTPTPTAEEMKLETHLSSISSASSSHSYASPPQ 531
            |    |:..::.|  .:.|.......:.|.||....|.||..|....|||.||.||    .|||.
Human   501 PITTIHENEVVKS--PSQPGQSGLCGVAAAATGHTPPLAEAPKSVASLSSRSSLSS----LSPPG 559

  Fly   532 SPRIFQQSYERLTTKSILAKSGHNHFGHQ--SDTNNYSIDGYLHGSSNASSYSSYSASMTSSSLV 594
            ||.:.:.::.        ..|.|:...||  :|..:..:..:....|...:.....:....:|..
Human   560 SPLVLEGTFP--------MSSSHDASLHQFTADFEDCELSSHFADISLIENQILLDSDSGGASQS 616

  Fly   595 SSAQSNSSSIARRPAFESRARTKTDSLKHRQ-HSLGNSHNSESA 637
            .|...:.:..||.|.:|..|..:....|.|. |.||......||
Human   617 LSEDKDLNECAREPLYEGTADVEKSLPKRRVIHLLGEKTTCVSA 660

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG10508NP_001246859.1 CUE 291..327 CDD:270465 11/61 (18%)
WWC2NP_001397793.1 WW 12..41 CDD:459800
WW 59..88 CDD:459800 11/29 (38%)
Smc <173..>430 CDD:440809 56/311 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 441..462 0/20 (0%)
C2_Kibra 700..823 CDD:176062
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 873..895
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 935..1015
Interaction with PRKCZ. /evidence=ECO:0000269|PubMed:24682284 1055..1074
PRK10929 1103..>1185 CDD:236798
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1148..1167
Blue background indicates that the domain is not in the aligned region.

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