DRSC/TRiP Functional Genomics Resources

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Protein Alignment park and prkn

DIOPT Version :10

Sequence 1:NP_730600.1 Gene:park / 40336 FlyBaseID:FBgn0041100 Length:482 Species:Drosophila melanogaster
Sequence 2:NP_001410636.2 Gene:prkn / 550328 ZFINID:ZDB-GENE-050417-109 Length:458 Species:Danio rerio


Alignment Length:466 Identity:208/466 - (44%)
Similarity:278/466 - (59%) Gaps:27/466 - (5%)


- Green bases have known domain annotations that are detailed below.


  Fly    32 IYVKTNTGKTLTVNLEPQWDIKNVKELVAPQLGLQPDDLKIIFAGKELSDATTIEQCDLGQQSVL 96
            ::|:.|:.....|.||....:..:||.|....|:|.|.|::||||:||.:.:|::.|||.:||.:
Zfish     3 VFVRFNSSHGFPVELEQGASVSELKEAVGRLQGVQSDQLRVIFAGRELCNESTLQGCDLPEQSTV 67

  Fly    97 HAIRLRPP---------VQRQKIQSATLEEEEPSLSDEASKPLNETL-LDLQLESEERLNITDEE 151
            |.:  .||         :|::::.|.........||.......:|.| :.|:.|:..|.:.....
Zfish    68 HVV--LPPSTSAHRSELIQQRRLGSGMESLTRLDLSSSRQTTASEGLAVILETEASRREDTAGHT 130

  Fly   152 RVRAKAHFFVHC-SQCDKLCNGKLRVRCALCKGGAFTVHRDPECWDDVLKSRRIPGHCESLEVAC 215
            ..:|.:.|:|.| :.|..:..|||||||..||.|..|:.|.|.||||||...||.|.|:|  ..|
Zfish   131 GAKAHSSFYVFCKTVCKAIQPGKLRVRCKDCKQGTLTLSRGPSCWDDVLLPNRIHGVCQS--QGC 193

  Fly   216 VDNAAGDPPFAEFFFKCAEHVSGGEKDFAAPLNLIKNNIKNVPCLACTDVSDTVLVFPCASQHVT 280
                  :...|||:.|||.|.: .:.|.:..|:||..|.:.|||:||||:...||||.||.:||.
Zfish   194 ------NGRLAEFYLKCASHPT-CDNDTSVALDLIMPNTRRVPCIACTDIMTPVLVFQCAERHVI 251

  Fly   281 CIDCFRHYCRSRLGERQFMPHPDFGYTLPCPAGCEHSFIEEIHHFKLLTREEYDRYQRFATEEYV 345
            |::||..||.|||.||||...|..||:|||.|||..|.|:|:|||::|..|:|:||||:|.||.|
Zfish   252 CLECFHLYCVSRLNERQFTQEPLLGYSLPCAAGCPDSLIKEVHHFRVLGEEQYERYQRYAAEECV 316

  Fly   346 LQAGGVLCPQPGCGMGLLVEPDCRKVTCQN-----GCGYVFCRNCLQGYHIGECLPEGTGASATN 405
            ||.||||||.||||.|||...:.|:|.|:.     |||:||||:|.:.:|.|.|....:.|||..
Zfish   317 LQMGGVLCPAPGCGAGLLPPDEERRVCCEPGNNGLGCGFVFCRDCKEEFHEGPCRHTTSTASAGA 381

  Fly   406 SCEYTVDPNRAAEARWDEASNVTIKVSTKPCPKCRTPTERDGGCMHMVCTRAGCGFEWCWVCQTE 470
            ...|.||...|..|||::||..||..:|.|||||:.|.|::||||||||.|..|.|||||:|:.|
Zfish   382 LQGYVVDEEAALRARWEQASQETITKTTHPCPKCQVPVEKNGGCMHMVCPRPQCKFEWCWLCRVE 446

  Fly   471 WTRDCMGAHWF 481
            |.|||||.|||
Zfish   447 WNRDCMGNHWF 457

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
parkNP_730600.1 Ubl_parkin 32..105 CDD:340496 27/81 (33%)
RING0_parkin 159..250 CDD:412057 38/91 (42%)
zf-RING_14 249..337 CDD:465601 49/87 (56%)
BRcat_RBR_parkin 322..398 CDD:439001 43/80 (54%)
Rcat_RBR_parkin 428..481 CDD:439018 34/52 (65%)
prknNP_001410636.2 None

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