Protein Alignment Ac78C and ACXE

DIOPT Version :10

• Sequence 1: NP_001262138.1
• Gene: Ac78C / 40333
• FlyBaseID: FBgn0024150
• Length: 1727
• Species: Drosophila melanogaster
• Sequence 2: NP_652601.3
• Gene: ACXE / 53426
• FlyBaseID: FBgn0040506
• Length: 1123
• Species: Drosophila melanogaster
• Alignment Length: 1412
• Identity: 325/1412 - (23%)
• Similarity: 523/1412 - (37%)
• Gaps: 485/1412 - (34%)

  Fly   328 LIIVNVVDFVLKIVLAFVWIMRRSELGPIESDDGTSMATAITWSVCCGIANMAICFLGYWRCFAN 392
            ||:|..|:|..:.:....|.|..|.:                      .|::.:.|........:
  Fly    90 LILVLSVNFCDEFIAKHTWYMYASSI----------------------FASLTLVFADLTESIYH 132

  Fly   393 NYLHWAAVCTWVLFNIQGFVGQGVGFADREYLVWYILFVIFVPYAMLPLPLKWCVVGGTITASCH 457
            .|.|     :|:|.                  .:|..::|::.|..||:..        |:.:..
  Fly   133 TYAH-----SWILG------------------TFYDTYIIYMIYMFLPIHF--------ISGAVL 166

  Fly   458 LAVIT--------IIKLQHGEATINPECVLFQI---FANFILYTAINVAGMYTKYLTDRGQRLAF 511
            ||::.        :|.:..|.|..  ...||.:   ..:.:.|..:|:.|::.:.:.|...|.:|
  Fly   167 LALLVSGLYILYFVIFIAQGFAQF--ASALFSVGGMSVDIVHYLCLNLVGIFYRVMNDTVVRSSF 229

  Fly   512 IETHKAMEHKKESEKELQRTQKLLDSILPNIVNNQIRSEM-------------YKGTDPTVETQF 563
            ::.|:.::.|........:.::|||||||..::..::.::             :...:.|:..|
  Fly   230 LDRHQYIKEKIWLRNARLQEKQLLDSILPPQISLPLQKDIQGRIVMAKQGIHSWTAMERTMAIQ- 293

  Fly   564 NKLYVYPMDNVSILFADIKGFTELASKTSAQQLVKILNDLFARFDRIAEDNHCLRVKLLGDCYYC 628
                ::|  :||||:||:..:|.|.:..:.:.|||:|:||:.|||..|......|:|.|||||||
  Fly   294 ----IHP--DVSILYADVVNYTHLTTTLTVEMLVKVLHDLYGRFDLAAYRYKVQRIKFLGDCYYC 352

  Fly   629 VSQFESDNWKTRPDHAVCSVETGLHMIKAIKDVRLHTHVDLNMRIGIHSGSVMCGVLGNKKWHFD 693
            |:.....:    ||||...|..||.||..|.:||....:|:|||||:|||::..||:|..|..||
  Fly   353 VAGLSDPD----PDHANNCVILGLSMINHIMEVRDIHGLDINMRIGVHSGNLFAGVIGEAKLQFD 413

  Fly   694 VWSNDVIIANHMESGGIPGRVHISEATLKCLN-DAYEVEPGNGGCRDNH-LKMLNVKTYLIKRTE 756
            :|..||.|||.:||.|:||.||||.|||..|: :.:::|.|....||:. ||...:::|:|
  Fly   414 IWGLDVTIANVLESTGVPGCVHISGATLNNLDVNRFDIEDGPEEARDHPLLKKYRIRSYII---- 474

  Fly   757 PLRPKRRFGTRSSAHLAGSVATAAPPCATPTALPKSISASGSGSIGGVTATGNDGASIDGRSLEY 821
              |.........|....|.:              .|||....|:...:    :|.|:...|:|.:
  Fly   475 --RQDLHMDDEDSDEFLGDL--------------HSISLCNMGAQPRI----SDSANQSLRALFH 519

  Fly   822 AATIAVPAQQPTQLLQQQQKKNISLNSLPNVVEGVAMDSRRIRNGCGVMGGAGGTGGGGTGPCGM 886
                       .:|.::.:|..:|           |...:|:                 .|.|..
  Fly   520 -----------EELREEFRKMPVS-----------AFSPKRL-----------------LGICRF 545

  Fly   887 STVSSPTAMMSAPLEVQLRPRNGACSIQNLAEAIDGKGLIIEDESTTDWIPEIPFKNLNSPEDGL 951
            :|                                 ||              |:|
  Fly   546 NT---------------------------------GK--------------EVP----------- 552

  Fly   952 NRADSILVDTKEDHRVSVAVLDEEIDEFIEQNIQINSNKEIRREYLNPWTLKFKDKSQEQKFCQL 1016
                                        ..||:.|              .|.|.|...|:.:.:.
  Fly   553 ----------------------------AHQNLNI--------------CLTFTDPILERAYLKQ 575

  Fly  1017 REDMFRSNMLCVFVIWIFMVLCQVIIIPRCTRLIICLS---VGTVILTFCCVLVMAEEFP----- 1073
            .:.|::.:     :|....|.|.::.|......:||.|   :...:.|..|:|.:...:.
  Fly   576 TDYMYKYS-----IILSASVGCSLVYIELMDTQMICSSCFVLPASVATIQCILALIAWYKKYCWT 635

  Fly  1074 -----GLPRCLKTNSAKL--VHQRQRRTLFICGVIVSMCMLSAIGLVLCPSSTYIGTADEHSRFL 1131
                 .:|......|..:  :|.:...:|.|...|....|:|:. .|:|
  Fly   636 RYGRNNVPHHYNGFSCFIFRIHDKILNSLPIRICIYLFLMISSF-FVMC---------------- 683

  Fly  1132 RMVSPYSNISMTEKEFKLNVYLSATIHHNITISTPASGGPTPLVDITSSGPSDEFVRSTLNALTL 1196
                 ...:|...:||:: .|:...:.|
  Fly   684 -----LIVMSCQREEFEM-AYIEERLFH------------------------------------- 705

  Fly  1197 NLTPPLPQSHRPYTLTTNGHSVSLSNLSYSDASVMQSSSDVEGQCAHPEYLVFTWVLC-LVSLAT 1260
                                        |...:.:         |.||      ||.. ::||..
  Fly   706 ----------------------------YEQEAHI---------CFHP------WVTTNMLSLMI 727

  Fly  1261 ALKLYY-----LVKALMALAMVAFYTTLIMMKFG-------SGDSFSLVELSRLGMPLGVQMLIL 1313
            .|...:     :||..:|:.....|..||..:|.       :.:.:...|.:        ..|::
  Fly   728 CLTFTFAHIPIMVKTAVAILETLAYLLLIFFQFDFVFHHSVTTNPYFKSEYA--------HALLI 784

  Fly  1314 LISFLVMVCYHARLVEVTSRLDFIW-----KEQAERELTNMKSNRALNDTLIKNILPDHVATYYL 1373
            .|:||:|. ...|.:|.|::::|.|     ||:....|||......||     ||||.|:...||
  Fly   785 CITFLIMF-VKERQIEFTNKVNFNWRVDLRKEENAASLTNHSIIIILN-----NILPSHIVDVYL 843

  Fly  1374 SDEHTDELYSKMHNLCGVMFASIPNFQ-DFYSEDIDNGKACIRILNEIICDFDELL---EEPRFA 1434
            :.....|||.:.:.:..||||.:.||: |..|         :|:|||||.:||.||   :|  :.
  Fly   844 NSLAKHELYFENYRMVSVMFAMLINFEMDLRS---------LRVLNEIIAEFDTLLLFYKE--YY 897

  Fly  1435 SVEKIKTVGATYMAAAGLNHEHLRLRGETS----------------------EDSVCDLVEFAFA 1477
            :|||||.||.|||||.||:   |...|.||                      :.|..||.|..|.
  Fly   898 TVEKIKIVGCTYMAACGLD---LNFAGSTSTNRKESIPPTEFNEEQSRRILFQQSNEDLDEVVFV 959

  Fly  1478 M--------------KQKLEEINGDA-FNNFQLRVGICSGPLVSGVIGARKPVYDIWGNTVNVAS 1527
            |              .:..:.|.||. ..:..:.:||.||.:::|::||.:|.||||||.||:||
  Fly   960 MTSYALDMMRTLAKSNEAYQSIAGDRNITDGTIAIGISSGEVMAGIVGASQPHYDIWGNPVNMAS 1024

  Fly  1528 RMDSTGENWRVQVPENTAELLCSRGYTCVKRGEIAVKGKGMMTTFYVHPKGISESQLISP---VR 1589
            ||:|||....:.|.|.|:|:|...|.||..||...|||:|.:.|:.|   ||.|:....|   .|
  Fly  1025 RMESTGLPGHIHVTEETSEILQQFGITCSYRGMTFVKGRGKIPTYLV---GIDENLNFIPQKATR 1086

  Fly  1590 MPAGIPLAQTPNLQRQTSHHGSFSAVVFGMLQASKRSTAIAGTPTGT 1636
            .|:....:...:||...:|              ::.:.:||.|...|
  Fly  1087 FPSHQERSTVISLQSTYTH--------------AENNNSIASTSRHT 1119

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac78C	NP_001262138.1	AC_N	<216..551	CDD:318454	42/233 (18%)
		Guanylate_cyc	566..753	CDD:425528	82/188 (44%)
		Adcy_cons_dom	929..1021	CDD:461877	9/91 (10%)
		Guanylate_cyc	1381..1576	CDD:425528	87/235 (37%)
ACXE	NP_652601.3	AcyC	65..453	CDD:441717	119/428 (28%)
		Nucleotidyl_cyc_III	290..459	CDD:448371	78/179 (44%)
		Nucleotidyl_cyc_III	851..1071	CDD:448371	86/233 (37%)