Protein Alignment CG10588 and NRDC

DIOPT Version :8

• Sequence 1: NP_001287135.1
• Gene: CG10588 / 40316
• FlyBaseID: FBgn0037037
• Length: 1058
• Species: Drosophila melanogaster
• Sequence 2: NP_002516.2
• Gene: NRDC / 4898
• HGNCID: 7995
• Length: 1219
• Species: Homo sapiens
• Alignment Length: 1144
• Identity: 340/1145 (30%)
• Similarity: 567/1145 (50%)
• Gaps: 166/1145 (14%)

  Fly    39 EPD--KSDGDSKLYRALTLSNGLRAMLISD----------------------------------- 66
            :|:  ||..|.|.||.:.|.|||:|:||||
Human   100 DPEIVKSPSDPKQYRYIKLQNGLQALLISDLSNMEGKTGNTTDDEEEEEVEEEEEDDDEDSGAEI 164

  Fly    67 ------SYIDEPSI-------------------HRA-------SRESLNS--------------- 84
                  .:.||...                   .||       .::.|.|
Human   165 EDDDEEGFDDEDEFDDEHDDDLDTEDNELEELEERAEARKKTTEKQQLQSLFLLWSKLTDRLWFK 229

  Fly    85 ------------STENFNG----------------------------KLAACAVLVGVGSFSEPQ 109
                        .|.|..|                            .|:|.|:.||||||::|.
Human   230 STYSKMSSTLLVETRNLYGVVGAESRSAPVQHLAGWQAEEQQGETDTVLSAAALCVGVGSFADPD 294

  Fly   110 QYQGLAHFVEHMIFMGSEKFPVENEFDSFVTKSGGFSNAHTENEETCFYFELDQTHLDRGMDLFM 174
            ...|||||:|||:||||.|:|.||.||:|:.|.||..||.|:.|.|.|.|::.:.:....:|.:.
Human   295 DLPGLAHFLEHMVFMGSLKYPDENGFDAFLKKHGGSDNASTDCERTVFQFDVQRKYFKEALDRWA 359

  Fly   175 NLMKAPLMLPDAMSRERSAVQSEFEQTHMRDEVRRDQILASLASEGYPHGTFSWGNYKTLKEGVD 239
            .....|||:.||:.||..||.||::.....|..|::.:..|||..|:|.|.|.|||.:|||....
Human   360 QFFIHPLMIRDAIDREVEAVDSEYQLARPSDANRKEMLFGSLARPGHPMGKFFWGNAETLKHEPR 424

  Fly   240 DSSL--HKELHKFYRDHYGSNRMVVALQAQLSLDELEELLVRHCADIPTSQQNSIDVSQLNYQKA 302
            .:::  |..|.:|:..:|.|:.|.:.:|::.:||.||:.:....:.||.:.....:...|.  ..
Human   425 KNNIDTHARLREFWMRYYSSHYMTLVVQSKETLDTLEKWVTEIFSQIPNNGLPRPNFGHLT--DP 487

  Fly   303 FRDQFYKDVFLVQPVEDVCKLELTWVLPPMKNFYRSKPDMFISQLIGYEGVGSLCAYLRHHLWCI 367
            |....:..::.|.|:..:..|.:||.|||.:..||.||..:||.|:|:||.||:.::||...|.:
Human   488 FDTPAFNKLYRVVPIRKIHALTITWALPPQQQHYRVKPLHYISWLVGHEGKGSILSFLRKKCWAL 552

  Fly   368 SVVAGVAESSFDSNSIYSLFNICIYLSDDGFDHIDEVLEATFAWVKLIINSDQLQDSYKESQQIE 432
            ::..|..|:.|:.||.||:|:|.|.|:|:|::|..||....|.::|::......:..::|.::||
Human   553 ALFGGNGETGFEQNSTYSVFSISITLTDEGYEHFYEVAYTVFQYLKMLQKLGPEKRIFEEIRKIE 617

  Fly   433 NNNFRFQIEPPPIDHVQSIVESFNYLPSKDVLTGPQLYFQYEESAI-ELLRQHM-NKFNFNIMIS 495
            :|.|.:|.:..|:::|:::.|:....|.:|:|||.||.|:|:...| |.|.|.: .|.|..::..
Human   618 DNEFHYQEQTDPVEYVENMCENMQLYPLQDILTGDQLLFEYKPEVIGEALNQLVPQKANLVLLSG 682

  Fly   496 SYIPYEKNEYDQREPWFGTQFKTISMPPKWQTMWEQSATIK-ELHYPQPNPFVTTDFKIHWVESG 559
            :    .:.:.|.:|.|||||:....:...|..:|..:..:. :||.|..|.::.|||.:...:..
Human   683 A----NEGKCDLKEKWFGTQYSIEDIENSWAELWNSNFELNPDLHLPAENKYIATDFTLKAFDCP 743

  Fly   560 KPHVSRSPKALIRNDLCELWFRQDNIFKLPDGYINLYFITPLVRESVKQYMLGVLFTYLVEFRMA 624
            :   :..|..::......||:::||.||:|..||..:.|:||:::|....:|..:|..::...:|
Human   744 E---TEYPVKIVNTPQGCLWYKKDNKFKIPKAYIRFHLISPLIQKSAANVVLFDIFVNILTHNLA 805

  Fly   625 EQLYPALEAGLTYGLYIGDKGLVMRVSGYNEKLPLLVEIILNMMQTIELDIGQVNAFKDLKKRQI 689
            |..|.|..|.|.|.|..|:.||::||.|:|.|||||.::|::.:..............:..|:..
Human   806 EPAYEADVAQLEYKLVAGEHGLIIRVKGFNHKLPLLFQLIIDYLAEFNSTPAVFTMITEQLKKTY 870

  Fly   690 YNALINGKSLNLDLRLSILENKRFSMISKYES-VDDITMDDIKSFKENFHKKMYVKGLIQGNFTE 753
            :|.||..::|..|:||.|||..|:|||.||:: :|.::::.:.||.:.|..:::|:||:|||.|.
Human   871 FNILIKPETLAKDVRLLILEYARWSMIDKYQALMDGLSLESLLSFVKEFKSQLFVEGLVQGNVTS 935

  Fly   754 DQATDLMQKVLDTYKSEKLDNLSALDNHLLQIPLGSYYLRAKTLNEDDSNTIITNYYQIGPSDLK 818
            .::.|.::.|:|....:.|:....:...::::|.|.:..:.|.||:.|:|:.:|.|||.|...|:
Human   936 TESMDFLKYVVDKLNFKPLEQEMPVQFQVVELPSGHHLCKVKALNKGDANSEVTVYYQSGTRSLR 1000

  Fly   819 MECIMDLVELIVEEPFFNQLRTQEQLGYSLGIHQRIGYGVLAFLITINTQETKHRADYVEQRIEA 883
            ...:|:|:.:.:|||.|:.|||::.|||.:....|...|:|.|.:|:.||.||:.::.|:::||.
Human  1001 EYTLMELLVMHMEEPCFDFLRTKQTLGYHVYPTCRNTSGILGFSVTVGTQATKYNSEVVDKKIEE 1065

  Fly   884 FRSRMAELVSQMSDTEFKNIRETLINGKKLGDTSLDEEVLRNWSEIVTKEYFFNRIETQIQMLSH 948
            |.|...|.:..:::..|......||..|:..||.|.|||.|||:|:||::|.|:|:..:|:.|..
Human  1066 FLSSFEEKIENLTEEAFNTQVTALIKLKECEDTHLGEEVDRNWNEVVTQQYLFDRLAHEIEALKS 1130

  Fly   949 LTKEDVLNFLNDNDKNNLRKLSVQVV--GNHNQTSNSTAQASRSGSLSDLLDDVQDNMANETDSA 1011
            .:|.|::|:...:.....:.|||.||  |.:....:.|..:..|.|..:::
Human  1131 FSKSDLVNWFKAHRGPGSKMLSVHVVGYGKYELEEDGTPSSEDSNSSCEVM-------------- 1181

  Fly  1012 KPMTDKIRLEFLGES----DDPSSIKDIYAFKKDLYVFP 1046
                   :|.:|..|    |....|.||.||...|.:.|
Human  1182 -------QLTYLPTSPLLADCIIPITDIRAFTTTLNLLP 1213

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10588	NP_001287135.1	Ptr	27..980	CDD:223956	326/1073 (30%)
		Peptidase_M16	85..214	CDD:279066	56/157 (36%)
		Peptidase_M16_C	244..419	CDD:282978	56/175 (32%)
		Peptidase_M16_M	436..720	CDD:292805	90/287 (31%)
		Peptidase_M16_C	724..907	CDD:282978	55/183 (30%)
NRDC	NP_002516.2	Ptr	279..1157	CDD:223956	299/887 (34%)
		Peptidase_M16	279..405	CDD:279066	55/126 (44%)
		Peptidase_M16_C	430..616	CDD:282978	57/188 (30%)
		Peptidase_M16_M	621..902	CDD:292805	90/288 (31%)
		Peptidase_M16_C	907..1089	CDD:282978	55/182 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
eggNOG	1	0.900				E1_COG1025
Hieranoid	1	1.000
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	624	1.000	Inparanoid score	I851
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010
OrthoDB	1	1.010				D1008844at2759
OrthoFinder	1	1.000				FOG0004760
OrthoInspector	1	1.000				T609965
orthoMCL	1	0.900				OOG5_126910
Panther	1	1.100			O	PTHR43690
Phylome	1	0.910		0.667	Consistency score
RoundUp	0	0.000	Not matched by this tool.
TreeFam	1	0.960
User_Submission	0	0.000	Not matched by this tool.
	11	10.840