DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10588 and Y70C5C.1

DIOPT Version :9

Sequence 1:	NP_001287135.1	Gene:	CG10588 / 40316	FlyBaseID:	FBgn0037037	Length:	1058	Species:	Drosophila melanogaster
Sequence 2:	NP_507226.2	Gene:	Y70C5C.1 / 190566	WormBaseID:	WBGene00013492	Length:	985	Species:	Caenorhabditis elegans

Alignment Length:	977	Identity:	272/977 - (27%)
Similarity:	464/977 - (47%)	Gaps:	88/977 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 SVVVQYHEEPDKSDGDSKLYRALTLSNGLRAMLISDSYIDEPSIHRASRESLNSSTENFNGKLAA 95
            :||::.||...|...|.:.||.|.|:||:|.:|:||...|:                      :|
Worm     7 NVVLERHEFILKGAQDEREYRGLELTNGIRVLLVSDPTTDK----------------------SA 49

  Fly    96 CAVLVGVGSFSEPQQYQGLAHFVEHMIFMGSEKFPVENEFDSFVTKSGGFSNAHTENEETCFYFE 160
            .|:.|.||...:|.:..|||||.|||:|:|:.|:|.|||:..|:|...|.:||:|..:.|.::||
Worm    50 AALDVNVGHLMDPWELPGLAHFCEHMLFLGTAKYPSENEYFKFLTAHAGRANANTATDHTNYFFE 114

  Fly   161 LDQTHLDRGMDLFMNLMKAPLMLPDAMSRERSAVQSEFEQTHMRDEVRRDQILASLASEGYPHGT 225
            :....|...:|.|:....:|.....|..||..||.||.......|..|..|:..|.|..|:.:|.
Worm   115 VKPDQLPGALDRFVQFFLSPQFTESATEREVCAVDSEHSNNLNNDAWRFLQVHRSCAKPGHDYGK 179

  Fly   226 FSWGNYKTL-----KEGVDDSSLHKELHKFYRDHYGSNRMVVALQAQLSLDELEELLVRHCADIP 285
            |..||.|||     |:|::.   ...|.:|::..|.||.|...:..:.|||.||..|       .
Worm   180 FGTGNKKTLLEDARKQGIEP---RDALLQFHKKWYSSNIMTCCIIGKESLDVLESYL-------G 234

  Fly   286 TSQQNSIDVSQLNYQ--KAF---RDQFYKDVFLVQPVEDVCKLELTWVLPPMKNFYRSKPDMFIS 345
            |.:..:||..:|..|  |.|   .:|..|.:.:| |::|..::.:::..|.:...:.|:|:.:||
Worm   235 TFEFAAIDNKKLERQIWKEFPFGPEQLGKRIDVV-PIKDTRQISISFPFPDLTGEFLSQPEHYIS 298

  Fly   346 QLIGYEGVGSLCAYLRHHLWCISVVAG-VAESSFDSNSIYSLFNICIYLSDDGFDHIDEVLEATF 409
            .|||:||.|||.:.|:...|.:|:.:| |.:::...|     |.:.|.||.:|.:|:||:::..|
Worm   299 HLIGHEGHGSLLSELKRLGWVVSLQSGYVVQAAGFGN-----FQVGIELSTEGLEHVDEIIQLMF 358

  Fly   410 AWVKLIINSDQLQDSYKESQQIENNNFRFQIEPPPIDHVQSIVESFNYLPSKDVLTGPQLYFQYE 474
            .::.::.:|...|..::|..::....|||:.:..|:.....:......:|.|.||:.|.|...||
Worm   359 NYIGMMQSSGPKQWVHEELAELRAVTFRFKDKEQPMAMASCVAARLQRIPFKHVLSSPHLLTNYE 423

  Fly   475 ESAIELLRQHMNKFNFNIMISSYIPYEKNEYDQREPWFGTQFKTISMPPKWQTMWEQSATIKE-- 537
            ...|:.|...:...|..|.:.|. .::..|.:..||.:||:.|...:..:....:|::.....
Worm   424 PVRIKELLSMLIPSNMKIQVVSQ-KFKGQEGNTNEPVYGTEIKVTRISSETMQKYEEALKTSHHA 487

  Fly   538 LHYPQPNPFVTTDFKIHWVESGKPHVSRSPKALIRND---------LCELWFRQDNIFKLPDGYI 593
            ||.|:.|.::.|.|            .:.|:.|:::|         ...:||:||:.:|:|....
Worm   488 LHLPEKNQYIATKF------------DQKPRELVKSDHPRLINDDEWSRVWFKQDDEYKMPKQET 540

  Fly   594 NLYFITPLVRESVKQYMLGVLFTYLVEFRMAEQLYPALEAGLTYGLYIGDKGLVMRVSGYNEKLP 658
            .|...||:|.:|.:..:|..|:...:...:||:.|.|..|||.|.|.....|:.||||||.||..
Worm   541 KLALTTPIVSQSPRMTLLSRLWLRCLSDSLAEESYSAKVAGLNYELESSFFGVQMRVSGYAEKQA 605

  Fly   659 LLVEIILNMMQTIELDIGQVNAFKDLKKRQIYN-ALINGKSLNLDLRLSILENKRFSMISKYESV 722
            |..:.:...:...::|..:.:...|..||.:.| |......|:......::.:|.:|........
Worm   606 LFSKHLTKRLFNFKIDQTRFDVLFDSLKRDLTNHAFSQPYVLSQHYTELLVVDKEWSKQQLLAVC 670

  Fly   723 DDITMDDIKSFKENFHKKMYVKGLIQGNFTEDQATDLMQKVLDTYKSEKLDNLSALDN-HLL--- 783
            :.:.::|::.|.:...:..:::.|:.||.||.:...|.:.::|..||....:.....| |:|
Worm   671 ESVKLEDVQRFGKEMLQAFHLELLVYGNSTEKETIQLSKDLIDILKSAAPSSRPLFRNEHILRRE 735

  Fly   784 -QIPLGSYYLRAKTLNEDDSNTI-ITNYYQIGPSDLKMECIMDLVELIVEEPFFNQLRTQEQLGY 846
             |:..|..|:........|...: :|  ||||..:.....::.|::.::.||.|:.|||:|.|||
Worm   736 IQLNNGDEYIYRHLQTTHDVGCVQVT--YQIGVQNTYDNAVIGLIKNLITEPAFDTLRTKESLGY 798

  Fly   847 SLGIHQRIGYGVLAFLITINTQETKHRADYVEQRIEAFRSRMAELVSQMSDTEFKNIRETLINGK 911
            .:........|.:|..|.:...::   .|:|.:|||||...:.:.:.:|...||:|....||...
Worm   799 IVWTRTHFNCGTVALQILVQGPKS---VDHVLERIEAFLESVRKEIVEMPQEEFENRVSGLIAQL 860

  Fly   912 KLGDTSLDEEVLRNWSEIVTKEYFFNRIETQIQMLSHLTKEDVLNFLNDNDKNNL---RKLSVQV 973
            :....:|.....:.|.||..::|.|.|||..:::|..:.||||:...:...:...   |||:|.|
Worm   861 EEKPKTLSCRFKKFWDEIECRQYNFTRIEEDVELLKTIKKEDVIALFDKKIRKGAAERRKLAVIV 925

  Fly   974 VG 975
            .|
Worm   926 HG 927

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10588	NP_001287135.1	Ptr	27..980	CDD:223956	272/977 (28%)
		Peptidase_M16	85..214	CDD:279066	44/128 (34%)
		Peptidase_M16_C	244..419	CDD:282978	52/180 (29%)
		Peptidase_M16_M	436..720	CDD:292805	74/295 (25%)
		Peptidase_M16_C	724..907	CDD:282978	48/188 (26%)
Y70C5C.1	NP_507226.2	Ptr	6..929	CDD:223956	272/977 (28%)
		Peptidase_M16	36..174	CDD:279066	51/159 (32%)
		Peptidase_M16_C	200..382	CDD:282978	55/194 (28%)
		Peptidase_M16_M	385..669	CDD:292805	74/296 (25%)
		Peptidase_M16_C	672..850	CDD:282978	46/182 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1025
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG63000
OrthoDB	1	1.010	-	-		D1008844at2759
OrthoFinder	1	1.000	-	-		FOG0000548
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100422
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.730