DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG32432 and Ldlr

DIOPT Version :10

Sequence 1:NP_649266.1 Gene:CG32432 / 40310 FlyBaseID:FBgn0052432 Length:1307 Species:Drosophila melanogaster
Sequence 2:NP_786938.2 Gene:Ldlr / 300438 RGDID:2998 Length:879 Species:Rattus norvegicus


Alignment Length:715 Identity:135/715 - (18%)
Similarity:222/715 - (31%) Gaps:254/715 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   180 GAAGFPSSSSSISSSLGPGKPVNLQLAPG------------------SSSTGC-------SLAEF 219
            |||.....|...:.::...:|...|.|.|                  |...||       ...:|
  Rat   219 GAADCKDKSDEENCAVTTCRPDEFQCADGSCIHGSRQCDREHDCKDMSDELGCINVTQCDGPNKF 283

  Fly   220 SCSNGRCVPLSKYCNNLNDCGDGSDEPRFCTRCNRTYYGDIGQTYALELHRPKQDRVPFVCVLT- 283
            .|.:|.|:.|.|.||:..||.|.||||....:.|.....:.|.:     |..|..::.:.|:.. 
  Rat   284 KCHSGECISLDKVCNSARDCRDWSDEPIKECKTNECLDNNGGCS-----HICKDLKIGYECLCPS 343

  Fly   284 -FTAAGGQHGDVVQVTLDSFTIGRFTSYVHEGC--PDGYMQIAESARTPIGGMWCGSSWGPVLFY 345
             |....|...:.:                 :.|  ||...|:..:..   |...|....|   |:
  Rat   344 GFRLVDGHQCEDI-----------------DECQEPDTCSQLCVNLE---GSFKCECRAG---FH 385

  Fly   346 SETRS-----------LIFTIR--LNRLARDQSGYNFDFRIRYKVLSRDSSVTRYGGIKLAELAQ 397
            .:..:           |:||.|  :.::..|:|.|.........|::.|:.|.. ..|..::|:|
  Rat   386 MDPHTRVCKAVGSIGFLLFTNRHEVRKMTLDRSEYTSLIPNLKNVVALDTEVAN-NRIYWSDLSQ 449

  Fly   398 WHNRSSFLNQQQQQQQQQQQQQQQQQGAPGILEDFTNSSVARSDRYGQDFSLFSAYANNKTFMAS 462
            ....|:.::|.                     ...:..::...|.:..|                
  Rat   450 RKIYSAVMDQG---------------------TSLSYDAIISGDLHAPD---------------- 477

  Fly   463 LEKSLAKDEQNYTEPKYYLGDLIPGTYCSRIFSDCDKKPCRLQSP-NFPGIYPR----------- 515
               .||.|   :.....|..|.:|||     .|..|.|..|.::. ...|..||           
  Rat   478 ---GLAVD---WIHGNIYWTDSVPGT-----VSVADTKGVRRRTLFREKGSRPRAIVVDPVHGFM 531

  Fly   516 ----------------NLTCYYAVRQHDV--PHGKHALILVKQPKGNLVWISTQETAAAN----- 557
                            |....|::...|:  |:|    |.:..|.|.|.|:.::..:.::     
  Rat   532 YWTDWGTPAKIKKGGLNGVDIYSLVTEDIQWPNG----ITLDLPSGRLYWVDSKLHSISSIDVNG 592

  Fly   558 -----------KMAPPPS-ASDKDKKFEPRLKTWNYCDYIQENVKPKWKSTDYVTVYDGYTTRDP 610
                       ::|.|.| |..:||.:      |.  |.:.|.:    .|.:.:|          
  Rat   593 GGRKTILEDEKQLAHPFSLAIYEDKVY------WT--DVLNEAI----FSANRLT---------- 635

  Fly   611 IILKFCGGGQAVPAAVSSGPELLVEFS--TSPFGTFTGTSSQVLPLYGFQLEVEVQFVDIQSPTY 673
                  |....:.|.....||.:|.|.  |.|.|. ....:.|||..|      .|::.:.:|..
  Rat   636 ------GSDVNLVAKNLMSPEDIVLFHNVTQPRGV-NWCEATVLPNGG------CQYMCLPAPQI 687

  Fly   674 SKNKKPCEFWIRGAGRGILESPKHSLA-PNS--------TCLYHL------QGLG----VFKTFD 719
            |.:                 |||.:.| |:.        :||..:      ||..    |..|..
  Rat   688 SAH-----------------SPKFTCACPDGMLLAKDMRSCLPEVDTVPTTQGTSTIGPVVTTSA 735

  Fly   720 HLSLSRRTSSQSGMHQ---PLSRFKVWISVLKFNLD----PEFGQIDETSVGAIGVLQTQEDCSG 777
            .:||.|:....:..|:   ..:|.|...|....:..    ||...::..:|.:    |.|.|.:|
  Rat   736 AVSLKRKEDPSATRHKEDPSATRHKEDPSATSTSRQPGDTPELSTVESVTVSS----QVQGDMAG 796

  Fly   778  777
              Rat   797  796

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG32432NP_649266.1 LDLa 214..245 CDD:197566 13/37 (35%)
CUB 503..646 CDD:238001 34/191 (18%)
LDLa 1203..1231 CDD:197566
LdlrNP_786938.2 Ldl_recept_a 25..58 CDD:395011
Ldl_recept_a 66..104 CDD:395011
Ldl_recept_a 107..143 CDD:395011
Ldl_recept_a 196..232 CDD:395011 4/12 (33%)
Ldl_recept_a 235..271 CDD:395011 5/35 (14%)
Ldl_recept_a 279..309 CDD:395011 12/29 (41%)
FXa_inhibition 319..353 CDD:464251 6/38 (16%)
EGF_CA 355..389 CDD:214542 8/56 (14%)
LDL-receptor class B 1 398..439 10/40 (25%)
NHL <435..628 CDD:302697 42/253 (17%)
NHL repeat 435..469 CDD:271320 6/55 (11%)
LDL-receptor class B 2 440..485 10/87 (11%)
NHL repeat 476..514 CDD:271320 13/64 (20%)
LDL-receptor class B 3 486..528 12/46 (26%)
LDL-receptor class B 4 529..572 6/46 (13%)
Ldl_recept_b 529..569 CDD:459654 6/43 (14%)
NHL repeat 555..600 CDD:271320 8/48 (17%)
LDL-receptor class B 5 573..615 7/41 (17%)
NHL repeat 606..628 CDD:271320 9/29 (31%)
LDL-receptor class B 6 616..658 13/69 (19%)
Ldl_recept_b 616..656 CDD:459654 12/67 (18%)
FXa_inhibition 674..711 CDD:464251 9/59 (15%)
Clustered O-linked oligosaccharides 717..788 14/70 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 718..797 18/83 (22%)
Required for MYLIP-triggered down-regulation of LDLR. /evidence=ECO:0000250|UniProtKB:P01130 830..879
NPXY motif. /evidence=ECO:0000250|UniProtKB:P01130 842..847
Blue background indicates that the domain is not in the aligned region.

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