DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG32432 and lrp-2

DIOPT Version :10

Sequence 1:NP_649266.1 Gene:CG32432 / 40310 FlyBaseID:FBgn0052432 Length:1307 Species:Drosophila melanogaster
Sequence 2:NP_491270.2 Gene:lrp-2 / 171981 WormBaseID:WBGene00003072 Length:4858 Species:Caenorhabditis elegans


Alignment Length:1267 Identity:231/1267 - (18%)
Similarity:384/1267 - (30%) Gaps:417/1267 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   214 CSLAEFSCS-NGRCVPLSKYCNNLNDCGDGSDE--------PRFCTRCNRTYYGDIGQTYALELH 269
            |...|::|| :.:||||.|:|:...||.|||||        |:....|.   ||.......::.:
 Worm   130 CDYNEYACSKSAQCVPLFKFCDGKRDCSDGSDEHSMCHVEDPKTADSCE---YGAAMTIDGIKCY 191

  Fly   270 RPK-------------------QDRVPFVCVL--------TFTAA---------GGQH--GDVVQ 296
            .||                   ::.:|.||..        |||.:         .|.|  .|..|
 Worm   192 CPKNKFLNEQGKCEFVNHCERTKNGLPPVCSQDCTDNKNGTFTCSCFDPRLTVVNGTHCVADKDQ 256

  Fly   297 VTLDSFTI-----------GRFTSY-----------------VHEGCPDGYMQI---AESARTPI 330
             |:.|..|           .:.:||                 .|...|:..:.|   :||.....
 Worm   257 -TIPSVAILTKKKLFVLQKNKMSSYSSMPRPLGKPGAMTLVIQHPDFPEATVPILCLSESPSAND 320

  Fly   331 GGMWCGSSWG--PVLFYSETRSLIFTIRLNRLAR-DQSGYNFDFRIRYKVLSRDSS----VTRYG 388
            ..:.||:..|  |.   ::|.::.|.:....:.| |..|.|:.|        .|:|    :.::.
 Worm   321 SYITCGNVEGSEPA---TKTYAIDFDLSSIHIIRFDNIGNNWIF--------TDASYYVFICKHN 374

  Fly   389 GIKLAELAQWHNRSSFLNQQQQQQQQQQQQQQQQQGAPGIL----EDFTNSSVARSD-RYGQDFS 448
            .::::..           :..........|..:..|..|.|    .|.....:.|.| ..||.:.
 Worm   375 SVRISSC-----------RTVTAGDMGTIQDMKYDGLNGQLLVSEVDVLQQGIWRIDVASGQRYR 428

  Fly   449 LFSAYANNKTFMASLEKSLAKDEQNYTEPKYYLGDLIPGTYCSRIFSDCDKKPCRLQSPNFPGIY 513
            |        ::......:||.|.  :||..|::                |.....:::.::...|
 Worm   429 L--------SYQPITSPALAIDP--FTETLYFV----------------DIGARSIKAVDYNANY 467

  Fly   514 PRNLT---CYYAVRQHDVPHGKHALILVKQPKGNLVWISTQETAAANKMAPPPSASDKDKKF--- 572
            .|.:.   ....|:..|...|:..|.|    |.|.|:       |.|.:     .|:.|.|.   
 Worm   468 SRTIVSGRIAKEVKMIDYAEGRLFLTL----KDNRVF-------AMNAL-----DSNSDMKIWQE 516

  Fly   573 -EPRLKTWNYCDYIQENV-----------KPKWKS---------------------TDYVTVYDG 604
             .|:.|..|      ||:           :..||:                     |......||
 Worm   517 VTPQRKQGN------ENIQILEVLHFRRNEHAWKNKGKNICKAAMCDDMCIGHINQTSSCFCRDG 575

  Fly   605 YTTRDPIILKFCGGGQAVPAAVSSGPELLVEFSTSPFGTFTGTSSQVLPLYGFQLEVEVQFVDIQ 669
            |...:    ..|...:.:     ...||.|.....|         ..:.:.||......:.:.:.
 Worm   576 YIQNN----TKCSASKDL-----KDEELFVLAQLRP---------SRIKILGFDKNYRTEIIGVS 622

  Fly   670 SPTYSKNKKPCEFWIRGAGRGILESPKHSLAPNS-----------TCLYHLQGLGVFKTFDHLSL 723
            .....|......|..:|....:.:..:|||....           |.:.:.:|:....|.|:|.:
 Worm   623 DLLNVKRPSAMTFDPKGEQLLMYDLRRHSLVVQKIGSTNYTVHGLTGIMNCEGMAYDFTSDNLYM 687

  Fly   724 S--RRTSSQSGMHQPLSRFKVWISVLKFNLDPEFGQIDETSVGAIGVLQTQEDCSGMLRIWDGTL 786
            :  ||..........||..||.:|          |.:......||.:                  
 Worm   688 TDQRRKIITVQRLSNLSIQKVVVS----------GNMSNPRAIAIHI------------------ 724

  Fly   787 RDAPVCKDLNCATETSSYNTLGHYTHNSTSVIARFCRGTIPRTCDRSNINETYARPCTISESYVS 851
                          ..||...|.:..::                     |:....|..|..|.:.
 Worm   725 --------------AKSYLFWGSWNEDN---------------------NDDEKIPAMIERSKLD 754

  Fly   852 TSDAITLELRNTESTVLRPLDFKLKYEFI---DLHQ---DGLPWGGGEHDCNRKFLSSMMDRKDP 910
            .|:..||..:|  :..:..|...||.:::   |.::   :.:.|.|.:.:........:......
 Worm   755 GSERKTLVSKN--AMWINGLTLDLKNDYLYWCDAYRNVIERIRWNGADREVVVHGADKISHPYGL 817

  Fly   911 AIFRSVRNIFL--FGRGGTRNLKC--------IYKFEAQRGERVRIKMRKVTTTNRPCYSRVDED 965
            |.|.:  :||.  |.:|..:.:..        ::::.|...|.:..|.....||: ||  ....:
 Worm   818 AFFDN--HIFYTEFKKGAVKRVNVDFPDDVQEVFQYSATVFELLVFKNSNPETTS-PC--STSSN 877

  Fly   966 INRSFCYGDT---NVRIEIFERPYHDSILLHRGCMCNSSNQSHLPVEYTSTSRDVEVHFIAQN-- 1025
            |...||:..:   :|..|..:....|.:.:.:...|....:...|     .:.|.|:.|...|  
 Worm   878 ICEHFCFASSCKGSVGCEPVKCGCADGMKVLKNGKCVKDEEWVDP-----NACDNEIEFTCLNSK 937

  Fly  1026 ----MTTLDDPDTVNFEGMFEFVKAPTSCKDGR---RKFGPSGT--IDMTF---GDVECRSRPWL 1078
                .:.|.|.|....:|..|  .|...|||.:   .||...||  :.|.|   |..:|......
 Worm   938 KCVPKSNLCDGDDDCGDGSDE--DANGICKDYKCVGNKFQCDGTTCLPMEFICDGKSDCYDGTDE 1000

  Fly  1079 IEPSNGNKFLYVRLKAIFLSKHNPTQTLNATYVQTDTWRCETKSR---AVLTTSEGLTIVACPLS 1140
            :|.               :.|..|....:.:..|....:|..||:   .|.....|.....||.|
 Worm  1001 LEK---------------ICKKAPIVKCSVSQFQCSKTKCIIKSKRCNGVQECDNGADEEDCPRS 1050

  Fly  1141 PDSNAYEF-----------------VEIFSSGWNERPNFALVNRSRAISVEFLRPGNGEYSFNWM 1188
            ...:..||                 ::.......|..|    ...:.:.....|..||:.:  .:
 Worm  1051 KLCDPDEFRCGTGLCIKQSQVCDGKMQCLDGLDEEHCN----EEEKCLQGRQFRCANGKST--CL 1109

  Fly  1189 ELIPRPTLSMAEDC-----------------------QFKCAELGACVNASVWCDGVVHCPSGDD 1230
            :||.|  .....||                       ||.||: |.|:.:...|||...|.:|:|
 Worm  1110 DLIFR--CDGVADCEDSSDESDEFCKGNSSSTCGKMNQFMCAD-GKCLRSFQLCDGFPDCLTGED 1171

  Fly  1231 ETFLQCSALMKLPAEILATL----CLIFVLSC 1258
            ||  :|...|......|:.|    |:...|.|
 Worm  1172 ET--ECPPSMCDSTTHLSCLNGQKCISKQLEC 1201

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG32432NP_649266.1 LDLa 214..245 CDD:197566 15/31 (48%)
CUB 503..646 CDD:238001 31/181 (17%)
LDLa 1203..1231 CDD:197566 11/27 (41%)
lrp-2NP_491270.2 LDLa 80..119 CDD:197566
LDLa 130..162 CDD:197566 15/31 (48%)
LY 668..702 CDD:214531 7/33 (21%)
LY 707..758 CDD:214531 14/113 (12%)
LY 759..801 CDD:214531 9/43 (21%)
LDLa 968..1000 CDD:197566 8/31 (26%)
LDLa 1013..1047 CDD:238060 6/33 (18%)
LDLa 1053..1087 CDD:238060 3/33 (9%)
LDLa 1098..1129 CDD:238060 8/34 (24%)
LDLa 1144..1175 CDD:238060 14/33 (42%)
LDLa 1182..1216 CDD:238060 5/20 (25%)
LDLa 1227..1261 CDD:197566
FXa_inhibition 1276..1305 CDD:464251
FXa_inhibition 1314..1344 CDD:464251
LY 1421..1463 CDD:214531
LY 1465..1508 CDD:214531
LY 1521..1555 CDD:214531
FXa_inhibition 2270..2309 CDD:464251
YvrE 2360..>2531 CDD:442613
LY 2480..2521 CDD:214531
LDLa 2681..2715 CDD:238060
LDLa 2717..2751 CDD:238060
LDLa <2774..2798 CDD:238060
LDLa 2819..2851 CDD:238060
LDLa 2856..2891 CDD:238060
LDLa 2904..2938 CDD:238060
LDLa 2988..3020 CDD:197566
LY 3231..3270 CDD:214531
Ldl_recept_b 3296..3336 CDD:459654
LY 3319..3362 CDD:214531
LY 3363..3404 CDD:214531
LDLa 3481..3514 CDD:197566
LDLa 3527..3564 CDD:197566
LDLa 3574..3609 CDD:238060
LDLa 3614..3649 CDD:197566
LDLa 3659..3693 CDD:238060
LDLa 3881..3912 CDD:238060
LY 4084..4125 CDD:214531
LY 4139..4181 CDD:214531
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.