Protein Alignment CG32432 and Lrp5

DIOPT Version :10

• Sequence 1: NP_649266.1
• Gene: CG32432 / 40310
• FlyBaseID: FBgn0052432
• Length: 1307
• Species: Drosophila melanogaster
• Sequence 2: NP_032539.2
• Gene: Lrp5 / 16973
• MGIID: 1278315
• Length: 1614
• Species: Mus musculus
• Alignment Length: 259
• Identity: 60/259 - (23%)
• Similarity: 89/259 - (34%)
• Gaps: 97/259 - (37%)

  Fly   183 GFPSSSSS--------ISSSLGP---GKPVNLQL--------APGSSSTGCSLA----EFSCSNG 224
            |||..:..        .|:|..|   |:.|:|:|        ...|....|...    :|.|::|
Mouse  1281 GFPECADQSDEEGCPVCSASQFPCARGQCVDLRLRCDGEADCQDRSDEANCDAVCLPNQFRCTSG 1345

  Fly   225 RCVPLSKYCNNLNDCGDGSDEPRFCTRCNRTYYGDIGQTYALELHRPKQDRVPFVCVLTFTAAGG 289
            :||.:.:.|::..||.|||||    ..|              |:::|..|.:|        |...
Mouse  1346 QCVLIKQQCDSFPDCADGSDE----LMC--------------EINKPPSDDIP--------AHSS 1384

  Fly   290 QHGDVVQVTLDSFTIG------------RFTS----YVHE---GCPD---GYMQIAESARTPIGG 332
            ..|.|:.:.|..|.:|            |:|.    :.||   |.|.   .::....|...|..|
Mouse  1385 AIGPVIGIILSLFVMGGVYFVCQRVMCQRYTGASGPFPHEYVGGAPHVPLNFIAPGGSQHGPFPG 1449

  Fly   333 MWCGSS----------WGPVLFY-------------SETRSLIFTIRLN---RLARDQSGYNFD 370
            :.|..|          .|.|..|             |.|::.::...||   ..|.|.|.||.|
Mouse  1450 IPCSKSVMSSMSLVGGRGSVPLYDRNHVTGASSSSSSSTKATLYPPILNPPPSPATDPSLYNVD 1513

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG32432	NP_649266.1	LDLa	214..245	CDD:197566	12/34 (35%)
		CUB	503..646	CDD:238001
		LDLa	1203..1231	CDD:197566
Lrp5	NP_032539.2	YncE	4..213	CDD:442618
		Beta-propeller 1	31..287
		LY	101..141	CDD:214531
		Ldl_recept_b	162..202	CDD:459654
		LY	186..228	CDD:214531
		LY	229..270	CDD:214531
		LDL-receptor class B 5	247..289
		FXa_inhibition	298..335	CDD:464251
		Beta-propeller 2	340..601
		LY	365..405	CDD:214531
		LY	407..449	CDD:214531
		LY	450..493	CDD:214531
		LY	494..536	CDD:214531
		LY	537..570	CDD:214531
		FXa_inhibition	604..639	CDD:464251
		Beta-propeller 3	643..902
		YncE	<653..781	CDD:442618
		LY	709..751	CDD:214531
		LY	798..837	CDD:214531
		LY	837..878	CDD:214531
		FXa_inhibition	905..940	CDD:464251
		Beta-propeller 4	944..1211
		LY	969..1008	CDD:214531
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1002..1025
		LY	1059..1102	CDD:214531
		LY	1103..1145	CDD:214531
		FXa_inhibition	1216..1252	CDD:464251
		LDLa	1258..1294	CDD:238060	3/12 (25%)
		LDLa	1297..1331	CDD:238060	8/33 (24%)
		LDLa	1335..1369	CDD:238060	13/37 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1474..1498		2/23 (9%)
		PPPSP motif A	1499..1505		0/5 (0%)
		PPPSP motif B	1537..1544
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1567..1599
		PPPSP motif C	1573..1580
		PPPSP motif D	1590..1595
		PPPSP motif E	1604..1611