DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG32432 and Lrp1

DIOPT Version :10

Sequence 1:NP_649266.1 Gene:CG32432 / 40310 FlyBaseID:FBgn0052432 Length:1307 Species:Drosophila melanogaster
Sequence 2:XP_036011543.1 Gene:Lrp1 / 16971 MGIID:96828 Length:4562 Species:Mus musculus


Alignment Length:1579 Identity:277/1579 - (17%)
Similarity:437/1579 - (27%) Gaps:704/1579 - (44%)


- Green bases have known domain annotations that are detailed below.


  Fly   214 CSLAEFSCSNGR--CVPLSKYCNNLNDCGDGSDEPRFCTRCNRTYYG------------------ 258
            |......|:|..  |:|..|.|:..:||||||||...|.:|:....|                  
Mouse  1163 CRPPSHPCANNTSVCLPPDKLCDGKDDCGDGSDEGELCDQCSLNNGGCSHNCSVAPGEGIVCSCP 1227

  Fly   259 ---DIG--------QTYA----------------------------------------------- 265
               ::|        |:|.                                               
Mouse  1228 LGMELGSDNHTCQIQSYCAKHLKCSQKCDQNKFSVKCSCYEGWVLEPDGESCRSLDPFKPFIIFS 1292

  Fly   266 -------LELHRPKQDRVPFVCVLTFTAAGGQH--------GDVVQ------VTLDSFTIGRFTS 309
                   ::||  |.|....|..|..|.|...|        .|||:      ..||:..:..|..
Mouse  1293 NRHEIRRIDLH--KGDYSVLVPGLRNTIALDFHLSQSALYWTDVVEDKIYRGKLLDNGALTSFEV 1355

  Fly   310 YVHEG--CPDG------------------YMQIAE---SART----------------PIGGMWC 335
            .:..|  .|:|                  .:::|:   :.||                |..|:..
Mouse  1356 VIQYGLATPEGLAVDWIAGNIYWVESNLDQIEVAKLDGTLRTTLLAGDIEHPRAIALDPRDGILF 1420

  Fly   336 GSSW-------------------------------GPVLFYSETRSLIFTIRLNRL--AR-DQSG 366
            .:.|                               |..:.|.|.|.|....|.:.:  || |.||
Mouse  1421 WTDWDASLPRIEAASMSGAGRRTIHRETGSGGWPNGLTVDYLEKRILWIDARSDAIYSARYDGSG 1485

  Fly   367 YNFDFRIRYKVLSRDSSVTRYGG---------IKLAELAQW--HNRSSFLNQQQQQQQQQQQQQQ 420
            :....| .::.||...:||.|||         ..||:..:|  ||.:.......|....|.....
Mouse  1486 HMEVLR-GHEFLSHPFAVTLYGGEVYWTDWRTNTLAKANKWTGHNVTVVQRTNTQPFDLQVYHPS 1549

  Fly   421 QQQGAPGILE--------------DFTNSSVA----------RSDRYGQDFSLFSAYAN------ 455
            :|..||...|              :: |.:|:          :.:....:|..|..||.      
Mouse  1550 RQPMAPNPCEANGGRGPCSHLCLINY-NRTVSCACPHLMKLHKDNTTCYEFKKFLLYARQMEIRG 1613

  Fly   456 ---NKTFMASLEKSLAKDEQNYT-------EPKYYLGDL---------IPGTYCSRIFS------ 495
               :..:...:......|..|.|       |.:.|..|:         |.||....:.|      
Mouse  1614 VDLDAPYYNYIISFTVPDIDNVTVLDYDAREQRVYWSDVRTQAIKRAFINGTGVETVVSADLPNA 1678

  Fly   496 -----------------DCDKKPCR---------------LQSPNFPGIYPRNLTCYYA----VR 524
                             |.:||...               |:.|:...::|.....|:.    :.
Mouse  1679 HGLAVDWVSRNLFWTSYDTNKKQINVARLDGSFKNAVVQGLEQPHGLVVHPLRGKLYWTDGDNIS 1743

  Fly   525 QHDVPHGKHALILVKQ----------PKGNLVWIST--------------------------QET 553
            ..::....|.|:...|          |:..|.|||:                          :.|
Mouse  1744 MANMDGSNHTLLFSGQKGPVGLAIDFPESKLYWISSGNHTINRCNLDGSELEVIDTMRSQLGKAT 1808

  Fly   554 AAA---NKMAPPPSASDKDKKFEPRLKTWNYCD------------------YIQENVKPKWKSTD 597
            |.|   :|:......|:|       :.|.|..|                  ...|:::.:.:.|:
Mouse  1809 ALAIMGDKLWWADQVSEK-------MGTCNKADGSGSVVLRNSTTLVMHMKVYDESIQLEHEGTN 1866

  Fly   598 YVTVYDG----------YTTRDPIILKFCGGGQAVPAAVSSGPELLVEFSTSPFGTF-------- 644
            ..:|.:|          .|||..:    |..|.    ::.||.:     :....|:|        
Mouse  1867 PCSVNNGDCSQLCLPTSETTRSCM----CTAGY----SLRSGQQ-----ACEGVGSFLLYSVHEG 1918

  Fly   645 --------TGTSSQVLPLYGFQLEVEVQF---------VDIQSPTYSKNKKPCEFW-----IRGA 687
                    ...|..::|:.|..|.|.:.|         ||:...|.|:.|:. :.|     ..|.
Mouse  1919 IRGIPLDPNDKSDALVPVSGTSLAVGIDFHAENDTIYWVDMGLSTISRAKRD-QTWREDVVTNGI 1982

  Fly   688 GRGILESPKHSLAPNSTCLYHLQGLGV----------FKTFDHLSLSRRTSS------QSGMHQP 736
            ||                   ::|:.|          .:.||.:.::|...|      ..|:.:|
Mouse  1983 GR-------------------VEGIAVDWIAGNIYWTDQGFDVIEVARLNGSFRYVVISQGLDKP 2028

  Fly   737 LSRFKVWISVLKFNLDPEFGQIDETSVGAIGVLQTQEDCSGMLRIWDGTLRDAPVCKDLNCATET 801
            .:          ..:.||.|.:..|.                   |                   
Mouse  2029 RA----------ITVHPEKGYLFWTE-------------------W------------------- 2045

  Fly   802 SSYNTLGHYTHNSTSVIARFCRGTIPRTCDRSNINETYARPCTISESY-----------VSTSDA 855
                  |||        .|..|..:..|.....:|.:.:.|..||..|           :...:.
Mouse  2046 ------GHY--------PRIERSRLDGTERVVLVNVSISWPNGISVDYQGGKLYWCDARMDKIER 2096

  Fly   856 ITLELRNTESTVLRPLDFKLKYEF-IDLHQDGLPWGGGEH-------DCNRKFLSSM-------M 905
            |.||.......||...:..:   | :.:.:|.:.|....|       .|......|:       :
Mouse  2097 IDLETGENREVVLSSNNMDM---FSVSVFEDFIYWSDRTHANGSIKRGCKDNATDSVPLRTGIGV 2158

  Fly   906 DRKDPAIFRSVR----NIFLFGRGGTRNLKCIYKFEAQRGERVRIKMRKVTTTNRPC-------- 958
            ..||..:|...|    |:.....||.:.| |:|:...||.......|  :......|        
Mouse  2159 QLKDIKVFNRDRQKGTNVCAVANGGCQQL-CLYRGGGQRACACAHGM--LAEDGASCREYAGYLL 2220

  Fly   959 YSRVDEDINRSFCYGD---TNVRIEIFERPYHDSILLHRGCMCNSSNQSHLPVEY-TSTSRDV-- 1017
            ||  :..|.:|....|   .|..::.||.|.|            ..|...|..:| ..||...  
Mouse  2221 YS--ERTILKSIHLSDERNLNAPVQPFEDPEH------------MKNVIALAFDYRAGTSPGTPN 2271

  Fly  1018 -----EVHF---------------IAQNMTTLDDP------DTVNF-----------------EG 1039
                 ::||               |.:|:.:::..      ||:.:                 .|
Mouse  2272 RIFFSDIHFGNIQQINDDGSGRTTIVENVGSVEGLAYHRGWDTLYWTSYTTSTITRHTVDQTRPG 2336

  Fly  1040 MFEFVKAPT-SCKDGRRKFGPSGTIDMTFGDVECRSRPWLIEPSNGNKFLYVRLKAIFLSKHNPT 1103
            .||.....| |..|..|.|    .:|      ||::   |:..:|.|: |:..:....||..| .
Mouse  2337 AFERETVITMSGDDHPRAF----VLD------ECQN---LMFWTNWNE-LHPSIMRAALSGAN-V 2386

  Fly  1104 QTLNATYVQTDTW---------------------RCE--TKSRAVLTTSEGLTIVACPLSPDSNA 1145
            .||....::|...                     |||  ...|.|:..||       |:.|...|
Mouse  2387 LTLIEKDIRTPNGLAIDHRAEKLYFSDATLDKIERCEYDGSHRYVILKSE-------PVHPFGLA 2444

  Fly  1146 YEFVEIFSSGW----NERPNFALVNRSRAISVEFLRPGNGEYSF----NWMELIP---------- 1192
            .....||.:.|    .:|.|..:.:..:.:.|:..:...|..:.    |..||.|          
Mouse  2445 VYGEHIFWTDWVRRAVQRANKYVGSDMKLLRVDIPQQPMGIIAVANDTNSCELSPCRINNGGCQD 2509

  Fly  1193 --------------RPTLSMAED---------C----QFKCAELGACVNASVWCDGVVHCPSGDD 1230
                          |....:.||         |    :|:||. |.|::.|:.||||.||....|
Mouse  2510 LCLLTHQGHVNCSCRGGRILQEDFTCRAVNSSCRAQDEFECAN-GECISFSLTCDGVSHCKDKSD 2573

  Fly  1231 E------------TFLQCS 1237
            |            ||.||:
Mouse  2574 EKPSYCNSRRCKKTFRQCN 2592

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG32432NP_649266.1 LDLa 214..245 CDD:197566 13/32 (41%)
CUB 503..646 CDD:238001 34/244 (14%)
LDLa 1203..1231 CDD:197566 12/27 (44%)
Lrp1XP_036011543.1 LDLa 27..60 CDD:197566
LDLa 72..105 CDD:197566
FXa_inhibition 120..149 CDD:464251
FXa_inhibition 159..189 CDD:464251
LY 276..315 CDD:214531
LY 317..359 CDD:214531
LY 362..402 CDD:214531
FXa_inhibition 487..520 CDD:464251
LY 552..594 CDD:214531
LY 595..634 CDD:214531
LY 641..690 CDD:214531
LY <701..734 CDD:214531
FXa_inhibition 808..843 CDD:464251
LDLa 854..886 CDD:197566
LDLa 896..929 CDD:238060
LDLa 936..968 CDD:197566
LDLa 979..1012 CDD:238060
LDLa 1033..1066 CDD:238060
LDLa 1080..1115 CDD:238060
LDLa 1122..1158 CDD:238060
LDLa 1163..1196 CDD:238060 13/32 (41%)
FXa_inhibition 1203..1239 CDD:464251 3/35 (9%)
Vgb 1328..>1521 CDD:443399 35/193 (18%)
LY 1354..1394 CDD:214531 4/39 (10%)
LY 1398..1441 CDD:214531 3/42 (7%)
LY 1631..1667 CDD:214531 9/35 (26%)
LY 1668..1711 CDD:214531 4/42 (10%)
LY 1715..1752 CDD:214531 4/36 (11%)
LY 1752..1793 CDD:214531 8/40 (20%)
FXa_inhibition 1868..1904 CDD:464251 9/48 (19%)
LY 1934..1974 CDD:214531 10/40 (25%)
LY 1977..2017 CDD:214531 9/58 (16%)
LY 2018..2061 CDD:214531 13/104 (13%)
LY 2063..2105 CDD:214531 8/41 (20%)
FXa_inhibition 2177..2212 CDD:464251 8/37 (22%)
LY 2293..2333 CDD:214531 4/39 (10%)
Ldl_recept_b 2362..2404 CDD:459654 10/46 (22%)
LY 2388..2429 CDD:214531 6/40 (15%)
FXa_inhibition 2500..2532 CDD:464251 1/31 (3%)
LDLa 2545..2575 CDD:238060 13/30 (43%)
LDLa 2584..2618 CDD:238060 4/9 (44%)
LDLa 2623..2657 CDD:238060
LDLa <2684..2706 CDD:238060
LDLa 2714..2748 CDD:238060
LDLa 2752..2783 CDD:197566
LDLa 2791..2824 CDD:197566
LDLa 2835..2867 CDD:197566
LDLa 2875..2908 CDD:197566
LDLa 2925..2957 CDD:238060
FXa_inhibition 2969..2998 CDD:464251
EGF_CA 3000..>3029 CDD:214542
LY 3067..3111 CDD:214531
LY 3112..3154 CDD:214531
LY 3156..3198 CDD:214531
LY 3200..3241 CDD:214531
LY 3242..3282 CDD:214531
FXa_inhibition 3312..3348 CDD:464251
LDLa 3352..3383 CDD:238060
LDLa 3392..3426 CDD:238060
LDLa 3431..3466 CDD:238060
LDLa 3470..3503 CDD:197566
LDLa 3511..3544 CDD:197566
LDLa 3554..3588 CDD:238060
LDLa 3593..3627 CDD:238060
LDLa 3631..3665 CDD:238060
LDLa 3671..3703 CDD:197566
LDLa 3713..3749 CDD:238060
LDLa 3764..3794 CDD:238060
YncE 3880..4082 CDD:442618
LY 3973..4010 CDD:214531
Ldl_recept_b 4031..4072 CDD:459654
LY 4055..4096 CDD:214531
Blue background indicates that the domain is not in the aligned region.

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