Protein Alignment CG32432 and Ldlr

DIOPT Version :10

• Sequence 1: NP_649266.1
• Gene: CG32432 / 40310
• FlyBaseID: FBgn0052432
• Length: 1307
• Species: Drosophila melanogaster
• Sequence 2: NP_034830.2
• Gene: Ldlr / 16835
• MGIID: 96765
• Length: 862
• Species: Mus musculus
• Alignment Length: 636
• Identity: 114/636 - (17%)
• Similarity: 196/636 - (30%)
• Gaps: 241/636 - (37%)

  Fly   176 VSGSGAAGFPSSSSSISSSLGPGKPVNLQLAPGSSSTGCSLAEFSCSNGRCVPLSKYCNNLNDCG 240
            :.||...........:|..||   .||:....|.:       :|.|.:|.|:.|.|.|::..||.
Mouse   250 IHGSRQCDREHDCKDMSDELG---CVNVTQCDGPN-------KFKCHSGECISLDKVCDSARDCQ 304

  Fly   241 DGSDEPRFCTRCNRTYYGDIGQTYALELHRPKQDRVPFVCVLTFTAAGGQHGDVVQVTLDSFTIG 305
            |.||||....:.|.....:.|.:     |..|..::...|:
Mouse   305 DWSDEPIKECKTNECLDNNGGCS-----HICKDLKIGSECL------------------------ 340

  Fly   306 RFTSYVHEGCPDGYMQI-------AESARTP----------IGGMWCGSSWGPVLFYSETRS--- 350
                     ||.|:..:       .:..:.|          .|...|....|   |:.:..:
Mouse   341 ---------CPSGFRLVDLHRCEDIDECQEPDTCSQLCVNLEGSYKCECQAG---FHMDPHTRVC 393

  Fly   351 --------LIFTIR--LNRLARDQSGYNFDFRIRYKVLSRDSSVTRYGGIKLAELAQWHNRSSFL 405
                    |:||.|  :.::..|:|.|.........|::.|:.||. ..|..::|:|....|:.:
Mouse   394 KAVGSIGYLLFTNRHEVRKMTLDRSEYTSLLPNLKNVVALDTEVTN-NRIYWSDLSQKKIYSALM 457

  Fly   406 NQQQQQQQQQQQQQQQQQGAPGILEDFTNSSVARSDRYGQDFSLFSAYANNKTFMASLEKSLAKD 470
            :|                 ||.:..|    ::...|.:..|                   .||.|
Mouse   458 DQ-----------------APNLSYD----TIISEDLHAPD-------------------GLAVD 482

  Fly   471 EQNYTEPKYYLGDLIPGTYC---------SRIFSDCDKK--------------------PCRLQS 506
               :.....|..|.:||:..         ..:|.:...:                    |.:::.
Mouse   483 ---WIHRNIYWTDSVPGSVSVADTKGVKRRTLFQEAGSRPRAIVVDPVHGFMYWTDWGTPAKIKK 544

  Fly   507 PNFPGI-----------YPRNLTCYYAVRQHDVPHGK--------HALILVKQPKGNLVWISTQE 552
            ....|:           :|..:|.       |:..|:        |::..:....||...|...|
Mouse   545 GGLNGVDIHSLVTENIQWPNGITL-------DLSSGRLYWVDSKLHSISSIDVNGGNRKTILEDE 602

  Fly   553 TAAANKMAPPPS-ASDKDKKFEPRLKTWNYCDYIQENVKPKWKSTDYVTVYDGYTTRDPIILKFC 616
                |::|.|.| |..:||.:      |.  |.|.|.:    .|.:.:|..|.....:.::
Mouse   603 ----NRLAHPFSLAIYEDKVY------WT--DVINEAI----FSANRLTGSDVNLVAENLL---- 647

  Fly   617 GGGQAVPAAVSSGPELLVEFS--TSPFGTFTGTSSQVLPLYGFQ-LEVEVQFVDIQSPTY----- 673
                        .||.:|.|.  |.|.|.....::.:||..|.| |.:....:...||.:
Mouse   648 ------------SPEDIVLFHKVTQPRGVNWCETTALLPNGGCQYLCLPAPQIGPHSPKFTCACP 700

  Fly   674 -----SKNKKPCEFWI--------RGAGRGILES-----PKHS--LAPNST 704
                 :|:.:.|...:        ..|.|.::.:     ||||  |:..||
Mouse   701 DGMLLAKDMRSCLTEVDTVLTTQGTSAVRPVVTASATRPPKHSEDLSAPST 751

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG32432	NP_649266.1	LDLa	214..245	CDD:197566	11/30 (37%)
		CUB	503..646	CDD:238001	31/164 (19%)
		LDLa	1203..1231	CDD:197566
Ldlr	NP_034830.2	Ldl_recept_a	25..58	CDD:395011
		Ldl_recept_a	66..104	CDD:395011
		Ldl_recept_a	107..143	CDD:395011
		Ldl_recept_a	146..184	CDD:395011
		Ldl_recept_a	196..232	CDD:395011
		Ldl_recept_a	236..271	CDD:395011	5/23 (22%)
		Ldl_recept_a	279..309	CDD:395011	12/36 (33%)
		FXa_inhibition	319..>347	CDD:464251	7/65 (11%)
		EGF_CA	355..389	CDD:214542	5/36 (14%)
		LDL-receptor class B 1	398..439		10/40 (25%)
		LY	420..458	CDD:214531	9/38 (24%)
		LDL-receptor class B 2	440..485		13/87 (15%)
		Ldl_recept_b	440..483	CDD:459654	13/85 (15%)
		LDL-receptor class B 3	486..528		5/41 (12%)
		Ldl_recept_b	486..526	CDD:459654	5/39 (13%)
		LDL-receptor class B 4	529..572		5/49 (10%)
		Ldl_recept_b	529..569	CDD:459654	4/46 (9%)
		LY	553..595	CDD:214531	6/48 (13%)
		LDL-receptor class B 5	573..615		11/45 (24%)
		LDL-receptor class B 6	616..658		13/69 (19%)
		Ldl_recept_b	616..656	CDD:459654	12/67 (18%)
		FXa_inhibition	675..712	CDD:464251	6/36 (17%)
		Clustered O-linked oligosaccharides	722..770		9/30 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	730..761		7/22 (32%)
		Required for MYLIP-triggered down-regulation of LDLR. /evidence=ECO:0000250|UniProtKB:P01130	813..862
		NPXY motif. /evidence=ECO:0000250|UniProtKB:P01130	825..830