Protein Alignment CG32432 and LRP1

DIOPT Version :10

• Sequence 1: NP_649266.1
• Gene: CG32432 / 40310
• FlyBaseID: FBgn0052432
• Length: 1307
• Species: Drosophila melanogaster
• Sequence 2: XP_320185.5
• Gene: LRP1 / 1280340
• VectorBaseID: AGAMI1_005394
• Length: 4869
• Species: Anopheles gambiae
• Alignment Length: 1422
• Identity: 266/1422 - (18%)
• Similarity: 402/1422 - (28%)
• Gaps: 628/1422 - (44%)

  Fly   110 HCQSQQQQQQQQHQLQQQHQQSQHQQRR-------------HPLPATLTLLLCLGISLGMAATAA 161
            |.|.||.|||...|..||.:|.|.|.:|             |   |...||..:|....:|||:.
Mosquito    30 HLQKQQPQQQPLPQQPQQQRQRQRQGQRDGCVRASGIGGRAH---ANARLLAAVGTLALLAATSV 91

  Fly   162 AAGGG---GGGGGGAAPVSGSGAAG--------FPSSSSSISSSLGPGKPVNLQLA-PGSSSTGC 214
            .|.||   .|....:..:||:.||.        ..|....:..||....|....|| |..:...|
Mosquito    92 MAVGGVSLTGPDTASVQISGASAASTRWTKATETGSDHRRVLRSLQKPGPKQTSLASPEEAQVTC 156

  Fly   215 SLAEFSC-SNGRCVPLSKYCNNLNDCGDGSDEPR------------FCTRCNR------TYYGDI 260
            |.::|:| .:|:|:|....|:...||.|||||..            .||..||      |..||:
Mosquito   157 SQSQFTCVMDGKCIPALWRCDTSADCSDGSDEVGCDKAHACNEGMFHCTVSNRCIPHDWTCDGDV 221

  Fly   261 G---------------------------QTYAL----------------------ELHRPKQD-- 274
            .                           .|.||                      ||:....|
Mosquito   222 DCGLVEKYDMVDVSDEDPQLCRAHTKCLPTQALCSDGKCLEIDRFCDGAWDCSNDELNCSSNDTA 286

  Fly   275 ------------RVPFVCVLT------FTAAGGQHGDVVQVTLDSFTIGRFTSYVHEGCPDGYMQ 321
                        :..:.|.||      |.|...|....|....|...|        ||..|
Mosquito   287 TASAPTSACDALKCSYDCRLTSEGARCFCAKDSQPNGSVCEDFDECQI--------EGLCD---- 339

  Fly   322 IAESARTPIGGMWCGSSWGPV----------LFYSETRSLIFTIRLNRLARDQSGYNFDFRIRYK 376
              :..:...|...|..:.|.|          |...|..||.|
Mosquito   340 --QMCKNQPGAYQCSCTTGYVRQGNTCTAVNLPKDEPTSLFF----------------------- 379

  Fly   377 VLSRDSSVTRYGGIKLAELAQWHNRSSFL------NQQQQQQQQQQQQQQQQQGAPGILEDFTNS 435
                    |.:..:|...::   ||:|.|      |:..:::..:|...:.:  |..::......
Mosquito   380 --------TTFNKVKKVSIS---NRTSVLAGNFPTNETVEEEYLKQPNPRIR--AMEMVHRNRTF 431

  Fly   436 SVARSDRYGQDFSLFSAYANNKTFMASLEKSLAKDEQNYTEPKYYLGDLIPGTYCSRIFSDCDKK 500
            .:||.|  |:  ||...|:.:.|            ..::..|:   .||.|...        |..
Mosquito   432 CLARID--GK--SLLECYSVDNT------------SHSWVMPR---PDLFPNLE--------DIV 469

  Fly   501 PCRLQ--SPNFPGIYPRNLTCYYAVRQHDV-----PHGKHALILVK------QP--------KGN 544
            ..||.  |.|:          ||..:|.::     |...|..|:|:      :|        ||.
Mosquito   470 DIRLDWVSGNW----------YYLDQQREIIFVCSPQMVHCAIIVEALSEVLRPRRMALDPTKGF 524

  Fly   545 LV---WIS------------TQETA-AANKMAPPPSASDKDKKFEPRLKTWNYCDYIQENVKPKW 593
            |.   |.|            |..|: ..||:..|...:               .|.:.::|  .|
Mosquito   525 LFFSKWGSGDVSIERSLLDGTNRTSIVLNKIITPLDIA---------------LDLVMQHV--YW 572

  Fly   594 KSTDYVTV----YDGYTTRDP----------------------IILKFCGGGQAVPAAVSSGPEL 632
            ..|...||    |||.....|                      |.|.....|..|....::| |.
Mosquito   573 VDTHLDTVQRVNYDGSGRWFPKRSTQFLFNFQMLYALDVFERTIYLASWQNGSIVALNGTTG-EA 636

  Fly   633 LVEFSTSPFGTFT--------------------GTSSQVLPLY--------------GFQLEVEV 663
            .|....:|.....                    |.....:|::              |::|:.:.
Mosquito   637 RVIVPNAPHAVHLHVFHRQKQPEVAHPCRIQNGGCDQLCIPVWKKIGVAIAQCMCSPGYRLKTKS 701

  Fly   664 QFVDIQSPTYSKNKKPCEFWIRGAGRGILES----PKHSLAPNSTCLYHLQGLGVFKTFDHLSLS 724
            |.|.|:.||:....|.....|||...||...    |...|.|:.|..||::...:|  |.|
Mosquito   702 QCVLIKRPTFLLYAKSNPAMIRGFAVGIKSQEAIVPITDLGPHITFDYHVEDQLIF--FSH---- 760

  Fly   725 RRTSSQSGMHQPLSRFKVWISVLKFNLDPEFGQIDETSVGAIGVLQTQEDCSGMLRIWDGTLRDA 789
                                           |.||:.|..    ::.|:        .|||.|:.
Mosquito   761 -------------------------------GVIDKPSFR----IEAQK--------LDGTQREL 782

  Fly   790 PVCKDLNCATETSSYNTLGHYTHNSTSVIARFCRGTIPRTCDRSNINETYARPCTISESYVSTSD 854
            .:....:|  :..||:.||:....:.|              ||::|:
Mosquito   783 LLESPGSC--DGISYDWLGNNIFWTDS--------------DRNHIS------------------ 813

  Fly   855 AITLELRNTESTVLRPLDFKLKYEFIDLHQDGLPWG-----GGEHDCNRKFLSSMMDRKDPAIFR 914
            .|.|..:....||||.| :..|...:|..|..:.|.     .|..|      .:.|:...|.:.
Mosquito   814 VIKLGPKRMRYTVLRQL-YAPKSIVVDPKQGWMYWSSWSVPSGRID------RAWMNGTQPELL- 870

  Fly   915 SVRNIFLFGRGGTRNLKCIYKFEAQRGERVRIKMRKVTTTNRP------------------CYSR 961
                                                |.:..||                  |.:|
Mosquito   871 ------------------------------------VNSKERPIEWPTGLSIDMIQKRLYWCDAR 899

  Fly   962 VD--EDINRSFCYGDTNVRIEIFERPYHDSILLHRGCMCNSSNQSHLPVEYTSTSRDVEVH---- 1020
            :.  |.||.     |.:.|:.:|:                ..:|:..||.       :.||
Mosquito   900 LSFIESINL-----DGSNRVLLFD----------------GRSQNQFPVA-------LAVHRQLL 936

  Fly  1021 FIAQNM------TTLDDP---DTVNFE-----GMFEFVKAPTSCKDGRRKFGPSGTIDMTFGDVE 1071
            :.|.|:      ..|.||   :|:..|     |:..|        |...::|.:|   ....:::
Mosquito   937 YFADNVKGHIEKLNLSDPHLLETITIEKPQVLGLKIF--------DNLTQYGGNG---RNACEID 990

  Fly  1072 CRSRPWLIEPSNGNKFLYVRLKAIFLSKHNPTQTLNATYVQTDTWRCETKSRAVLTTSEGLTIVA 1136
            |                             |...|| |.|...:.:|| ..:.:..:|||..:..
Mosquito   991 C-----------------------------PGICLN-TPVAVASCKCE-DGQVLSLSSEGKPVAC 1024

  Fly  1137 CPLSPDSNAYEFVEIFSSGWNERPNFALVNRSRAISVEFLRPGNGEYSFNWMELIPRPTLSMAED 1201
            .|..        ::...:..|...:|...|:...|.:::...|:                   .|
Mosquito  1025 VPFD--------LQHSLASCNNSTHFLCRNKIDCIEIKYTCDGD-------------------RD 1062

  Fly  1202 CQ----------------------FKCAELGACVNASVWCDGVVHCPSGDDETFLQC 1236
            |:                      |||.| ..|::.|..|||.|.|....||.::.|
Mosquito  1063 CEDGSDEETTPDGPCDPNCDLERNFKCDE-QRCISRSHVCDGSVDCIDESDEDYINC 1118

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG32432	NP_649266.1	LDLa	214..245	CDD:197566	13/31 (42%)
		CUB	503..646	CDD:238001	40/225 (18%)
		LDLa	1203..1231	CDD:197566	11/49 (22%)
LRP1	XP_320185.5	None