DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CSN3 and Cops3

DIOPT Version :9

Sequence 1:	NP_524190.2	Gene:	CSN3 / 40308	FlyBaseID:	FBgn0027055	Length:	445	Species:	Drosophila melanogaster
Sequence 2:	NP_036121.1	Gene:	Cops3 / 26572	MGIID:	1349409	Length:	423	Species:	Mus musculus

Alignment Length:	441	Identity:	226/441 - (51%)
Similarity:	303/441 - (68%)	Gaps:	19/441 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGSALENYVNQVRTLSASGSYRELAEELPESLSLLARNWSILDNVLETLDMQQHSLGVLYVLLAK 65
            |.||||.:||.||.|||.|...:|.|.:.:|..|||:|.|.||.||..||:|:||||||.||..|
Mouse     1 MASALEQFVNSVRQLSAQGQMTQLCELINKSGELLAKNLSHLDTVLGALDVQEHSLGVLAVLFVK 65

  Fly    66 LHSASTANPEPVQLIQLMRDFVQRNNNEQLRYAVCAFYETCHLFTEFVVQKNLSILGIRIISRAI 130
            ....|.  |:...|...::.|:...|.|.:|||...|...||..|..:|::...:.||.|:.:||
Mouse    66 FSMPSV--PDFETLFSQVQLFISTCNGEHIRYATDTFAGLCHQLTNALVERKQPLRGIGILKQAI 128

  Fly   131 DQIRQLETQLTPIHADLCLLSLKAKNFSVVLPYLDADITDISTVAAECKTQQQQQSQHADANNDA 195
            |:::....|||.:|||||.|.|.||.|...|||||.|:.||      ||         .:...||
Mouse   129 DKMQMNTNQLTSVHADLCQLCLLAKCFKPALPYLDVDMMDI------CK---------ENGAYDA 178

  Fly   196 KYFLLYFYYGGMIYTAVKNYERALYFFEVCITTPAMAMSHIMLEAYKKFLMVSLIVEGKIAYIPK 260
            |:||.|:||||||||.:||:||||||:|..|||||||:||||||:|||:::||||:.||:..:||
Mouse   179 KHFLCYYYYGGMIYTGLKNFERALYFYEQAITTPAMAVSHIMLESYKKYILVSLILLGKVQQLPK 243

  Fly   261 NT-QVIGRFMKPMANHYHDLVNVYANSSSEELRIIILKYSEAFTRDNNMGLAKQVATSLYKRNIQ 324
            .| |::|||:||::|.||:|..||:.::..|||.::.|:||.|||||||||.||..:||||:|||
Mouse   244 YTSQIVGRFIKPLSNAYHELAQVYSTNNPSELRNLVSKHSETFTRDNNMGLVKQCLSSLYKKNIQ 308

  Fly   325 RLTKTFLTLSLSDVASRVQLASAVEAERYILNMIKSGEIYASINQKDGMVLFKDDPEKYNSPEMF 389
            |||||||||||.|:||||||:...|||:|:|:||:.|||:||||||||||.|.|:|||||:|.|.
Mouse   309 RLTKTFLTLSLQDMASRVQLSGPQEAEKYVLHMIEDGEIFASINQKDGMVSFHDNPEKYNNPAML 373

  Fly   390 LNVQNNITHVLDQVRQINKMEEEIILNPMYVKKALGSQDDDLTSQHPKTFS 440
            .|:...:...::...::..|::||.:||.:|:|::|||:|| :...|.::|
Mouse   374 HNIDQEMLKCIELDERLKAMDQEITVNPQFVQKSMGSQEDD-SGNKPSSYS 423

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CSN3	NP_524190.2	PCI	275..378	CDD:279707	68/102 (67%)
Cops3	NP_036121.1	PCI	259..362	CDD:396121	68/102 (67%)
Cops3	NP_036121.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	402..423		8/21 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167830725
Domainoid	1	1.000	243	1.000	Domainoid score	I2207
eggNOG	1	0.900	-	-		E1_KOG2582
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2710
Inparanoid	1	1.050	429	1.000	Inparanoid score	I1722
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55351
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005586
OrthoInspector	1	1.000	-	-		oto95008
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR10758
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6002
SonicParanoid	1	1.000	-	-		X5221
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.890