DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HIPP1 and hadhab

DIOPT Version :9

Sequence 1:	NP_649261.1	Gene:	HIPP1 / 40302	FlyBaseID:	FBgn0037027	Length:	926	Species:	Drosophila melanogaster
Sequence 2:	NP_001082906.1	Gene:	hadhab / 793834	ZFINID:	ZDB-GENE-041111-204	Length:	763	Species:	Danio rerio

Alignment Length:	247	Identity:	56/247 - (22%)
Similarity:	92/247 - (37%)	Gaps:	52/247 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   699 LLEQLNDTLSSVARKGEFNTV-LLTVEGPQFCQGIDCQELI----QGSLEKRKDSASQL------ 752
            |:.||.|||....:..|..|: .|.....:..:|:..:::.    :|.::|.:|.....
Zfish   217 LVHQLVDTLGPGLKSPEERTIEYLEEVAVEAARGLAQKKITLTKEKGWMQKIQDYVMSYPFVRQQ 281

  Fly   753 ---AVALKCYLRTLATFPKPLVAGIVGSQINLGVMQLPFADYVVASDDCSFETNYAKLGQLPEGY 814
               .|..|...:|...:|.||  .|:.| :..||.|.|...|:|.|.      .:.||....|..
Zfish   282 IYNTVEKKVMKQTKGLYPAPL--KIIES-VKAGVEQGPTTGYLVESQ------QFGKLAMTNESK 337

  Fly   815 A---LWHGHQRV--------SSEVHSRLFLMGERLFATELLESNSFVDK----ICKARNVNEMAL 864
            |   |:||....        ..||.: |.::|..|....:.:..  |||    |.|...|:.::.
Zfish   338 ALIGLYHGQVACKKNRFGTPEKEVKT-LAILGAGLMGAGIAQVT--VDKGIHTILKDTTVDGLSR 399

  Fly   865 A----------KAKQISTSSAEMYRTLKKLNHSAVNVTKFPRLDEELKVIGE 906
            .          |.|:.|.:|.|....|..|. ..::...|.:.|..::.:.|
Zfish   400 GEQQVFKGLNDKTKKKSLTSFERDTFLSNLT-GQLDYNGFNKADMIIEAVFE 450

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HIPP1	NP_649261.1	crotonase-like	673..870	CDD:119339	48/209 (23%)
hadhab	NP_001082906.1	fa_ox_alpha_mit	27..762	CDD:131494	56/247 (23%)
		crotonase-like	41..251	CDD:119339	9/33 (27%)
		3HCDH_N	363..541	CDD:280833	19/92 (21%)
		3HCDH	544..639	CDD:279114
		3HCDH	676..>750	CDD:279114
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1024
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900