DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG13251 and Ccdc66

DIOPT Version :9

Sequence 1:	NP_649246.1	Gene:	CG13251 / 40286	FlyBaseID:	FBgn0037014	Length:	1088	Species:	Drosophila melanogaster
Sequence 2:	NP_796085.3	Gene:	Ccdc66 / 320234	MGIID:	2443639	Length:	935	Species:	Mus musculus

Alignment Length:	693	Identity:	143/693 - (20%)
Similarity:	241/693 - (34%)	Gaps:	190/693 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   412 EQHERERARWA-NFNGGAGHQAAQQ-------------------------------PPGWLSRGM 444
            |:|:    ||| :|:....|..:|.                               ||..:....
Mouse   355 EEHD----RWAVHFDSLKSHPGSQSRLSSQLTHQHLESLCVSPDTQELADVNGVFTPPPGVQAEP 415

  Fly   445 HDLKDSEDDVQSMQSS----STYLRGQNAPLDAHTLAERMDKRRKAAEYHNAIKKQLHERELIRK 505
            .:.:.....|..|..|    :.:||...|.||...:.||..:|:|..|:..||..|:.|....::
Mouse   416 SEKEQRARPVLEMAVSHGPKTNFLRSMTALLDPAQIEERERRRQKQLEHQKAIMAQVEENRRKKR 480

  Fly   506 WEHERHRQEEQIEEERIRRQKQLEQERLEFERRTLQEREEAQQKKQQVMLDAIQKAEVAAKMERQ 570
            .|.|:.::|||..|.|:.|:::..|.:.|.:....::|||....|...:...:|:|:..|:..:|
Mouse   481 LEEEQRKKEEQELELRLAREREEMQRQYEEDILKQRQREEIMTLKTNELFHTMQRAQELAQRLKQ 545

  Fly   571 KRRMVRQPSKVSQETEEDESELIRVQSVEEEEDAEEKSGAVEPPSQEEETSNTPRGAPP----VM 631
            ::| :|:.::...:|    |.||  |::..:.|.:..:......|..|||::|...:|.    |.
Mouse   546 EQR-IRELAQKGHDT----SRLI--QNLGAQVDYKAFTTISSSHSDPEETADTSTASPKKDTGVQ 603

  Fly   632 SEEKVLIGTPINLRRTITKPIKQPRDSRKEDP-KEPTQTKVQTTFLGED---KENVALLMQPATL 692
            :::       :||  .|......|..|..|.. :..:..::...|.|:.   |||..|.|...|.
Mouse   604 TDD-------VNL--GIFNDALPPCGSVTEKGIRNISSPEISAEFSGQTDIRKENQELSMNKGTN 659

  Fly   693 IPLPVTSDIFGLQNAIGNLQIATYFMQPP----MQKPPETPGSYSKATMTHRTDTSIYTEDGYQA 753
            :         ..:|:..|.|...|.....    |:|.|:.|.......:......|.......|.
Mouse   660 L---------DKENSWHNGQCNQYRRTEKQTKLMKKCPKKPAWNINKPLKKYVPASAKYPAHLQK 715

  Fly   754 EKEEDPLTTARSGRTDLVTASGCFSPDSLEVDVAPVLIAETDKLALIPLKTPLQLGISNSSDDRG 818
            ||||..:.                              .:.:.|.|:....|     .|.|.:||
Mouse   716 EKEEKKVQ------------------------------RQMELLHLVERNNP-----ENLSQNRG 745

  Fly   819 EHNHEVGHQADVETQTELPLNCDLCLFHDNFYKVLLKREVSTTTTTQTSKS--QTQPAKESTAEK 881
            .......|:   ||::|..|:             |:|:......|...||.  ||.||.::
Mouse   746 ISPLATSHR---ETESESRLH-------------LIKKVEEPLKTPSVSKERFQTSPAVKN---- 790

  Fly   882 DHETTTTTTTTTTTTFKAKSKDKDKEKNLKRNLNKDKDANKMDDR-------------------- 926
                .|..|.:.......|:.|.:||     .|.......|:.|.
Mouse   791 ----RTQQTQSNVLHLPLKNNDYEKE-----TLTLGDGHTKLSDEMSEPSHFIPYVRTNEIYYLD 846

  Fly   927 PKWGVNRPVV---QYVKASDRDPFCLRKKKNHPSTAKPPRSLSMDSRLDSVALPE-----DRLIN 983
            |...::||..   ||.|:.|    |.|:::...|          |...|.:..|:     ||...
Mouse   847 PDAPLSRPSTQDNQYQKSHD----CAREQELFDS----------DHIRDPLLNPKLVKNRDRQQA 897

  Fly   984 IAGGPPSAAGELEEEGFLLKARNVCTEILPIKTDDKGRIFLNF 1026
            |..|    ..|| .:|.|.|.:.:.|.::|:..:.:.....:|
Mouse   898 ILKG----LSEL-RQGLLQKQKELETNLIPLTANQEDNFSSSF 935

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13251	NP_649246.1	CCDC66	445..580	CDD:291889	37/138 (27%)
Ccdc66	NP_796085.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	76..103
		CCDC66	407..559	CDD:291889	39/152 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	470..491		5/20 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	577..602		6/24 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	738..794		19/79 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850535
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28UYI
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR22736
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.930