DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Las and lias

DIOPT Version :9

Sequence 1:	NP_524183.2	Gene:	Las / 40259	FlyBaseID:	FBgn0029158	Length:	377	Species:	Drosophila melanogaster
Sequence 2:	NP_001103871.1	Gene:	lias / 393528	ZFINID:	ZDB-GENE-040426-1528	Length:	397	Species:	Danio rerio

Alignment Length:	371	Identity:	240/371 - (64%)
Similarity:	292/371 - (78%)	Gaps:	16/371 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 AEAPIVVATR---AASTNA--------EKLEEIRERLAKGPNFHDFVQNPDNTRNEWEQYDGKLR 62
            |||..|...|   ||||::        ::.:::||   .|.|..||:....:.:::||:|.|.|:
Zfish    26 AEAANVYCNRLSTAASTSSSSSPSTHNDRKKDLRE---DGLNLQDFISGELSEKSKWEEYRGNLK 87

  Fly    63 REKGEEQRLRLPPWLKTTIPVGKNYAKIKAQMRELKLSTVCEEARCPNIGECWGGGEHGTQTATI 127
            |||||  ||||||||||.||:||||.|:|..:|||.|.|||||||||||||||||||:.|.||||
Zfish    88 REKGE--RLRLPPWLKTEIPIGKNYNKLKNTLRELNLHTVCEEARCPNIGECWGGGEYATATATI 150

  Fly   128 MLMGDTCTRGCRFCSVKTARKPPPLDVNEPVNTATAIASWGLDYIVLTSVDRDDLPDGGSEHIAE 192
            ||||||||||||||||||||:|||||.:||.|||.|||:|||||:|||||||||:||||:||.|:
Zfish   151 MLMGDTCTRGCRFCSVKTARRPPPLDPDEPYNTAKAIAAWGLDYVVLTSVDRDDIPDGGAEHFAK 215

  Fly   193 TVREIKARNSNIFVECLVPDFRGNLECVKTIANSGLDVYAHNIETVEKLTPYVRDRRAHYRQTLQ 257
            ||..||.|||.|.||||.|||||:|..|:.||.|||||||||:|||.:|..:|||.||::.|:|.
Zfish   216 TVSNIKERNSKILVECLTPDFRGDLAAVEKIALSGLDVYAHNVETVRELQRHVRDPRANFDQSLS 280

  Fly   258 VLTEAKRFNPNLITKSSIMLGLGETDEEIENTLKDLREAGVDCVTLGQYMQPTNKHLKVIEYVTP 322
            ||..||:...:::||:||||||||||.:|:.||.:||::||||:|||||||||.:||||.|||||
Zfish   281 VLRHAKKVKSSVLTKTSIMLGLGETDAQIQATLTELRDSGVDCLTLGQYMQPTKRHLKVEEYVTP 345

  Fly   323 EKFKHWEERGNELGFLYTASGPLVRSSYKAGEFFITSILENRKKRQ 368
            |||..||:.|.|:||:||||||||||||||||||:.::||.||..:
Zfish   346 EKFAFWEKVGQEMGFIYTASGPLVRSSYKAGEFFLKNLLEKRKTEE 391

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Las	NP_524183.2	LIAS_N	3..108	CDD:293486	53/109 (49%)
		PLN02428	19..368	CDD:215236	235/356 (66%)
		Radical_SAM	131..307	CDD:100105	121/175 (69%)
lias	NP_001103871.1	LIAS_N	53..131	CDD:293486	44/82 (54%)
		PLN02428	58..394	CDD:215236	231/339 (68%)
		Radical_SAM	154..330	CDD:100105	121/175 (69%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581714
Domainoid	1	1.000	231	1.000	Domainoid score	I2374
eggNOG	1	0.900	-	-		E1_COG0320
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4997
Inparanoid	1	1.050	489	1.000	Inparanoid score	I1383
OMA	1	1.010	-	-		QHG60997
OrthoDB	1	1.010	-	-		D464271at33208
OrthoFinder	1	1.000	-	-		FOG0003202
OrthoInspector	1	1.000	-	-		oto39699
orthoMCL	1	0.900	-	-		OOG6_100980
Panther	1	1.100	-	-	LDO	PTHR10949
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R658
SonicParanoid	1	1.000	-	-		X2153
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800