Protein Alignment CG5262 and TMEM104

DIOPT Version :10

• Sequence 1: NP_649223.1
• Gene: CG5262 / 40258
• FlyBaseID: FBgn0036988
• Length: 509
• Species: Drosophila melanogaster
• Sequence 2: NP_060198.3
• Gene: TMEM104 / 54868
• HGNCID: 25984
• Length: 496
• Species: Homo sapiens
• Alignment Length: 509
• Identity: 221/509 - (43%)
• Similarity: 330/509 - (64%)
• Gaps: 36/509 - (7%)

  Fly     9 EAAPTYSNLVGFIFIFNLIVGTGALTLPGVFARAGWMLSLIVIVLLAIISYMTVTFIIEAMACAN 73
            |....||:.||.:::|||||||||||:|..||.|||::||:::|.|..:|::|.||:|||||.||
Human     7 ETGELYSSYVGLVYMFNLIVGTGALTMPKAFATAGWLVSLVLLVFLGFMSFVTTTFVIEAMAAAN 71

  Fly    74 AIRNWQTLQALRQSRSSAENSENDDNA----DDVSLASGAEQVGDFERVP-LTIQNR-EFHYYQL 132
            |..:|:.::.|::       .|:||::    .||.:....|:.   |:.| |::|.| ..:.:::
Human    72 AQLHWKRMENLKE-------EEDDDSSTASDSDVLIRDNYERA---EKRPILSVQRRGSPNPFEI 126

  Fly   133 SHKFELGEMATLFFNEFGRVMFYLCLIVYLYGDLSIYSAAVARSLRDVVCDQTNGTDTNNLMYWP 197
            :.:.|:|:||::|||:.|..:||.|:||||||||:||:|||..||..|.|..| |.|:..:   .
Human   127 TDRVEMGQMASMFFNKVGVNLFYFCIIVYLYGDLAIYAAAVPFSLMQVTCSAT-GNDSCGV---E 187

  Fly   198 GDFENNTSLACWKEHTISRLNMYRVLLIGFTLIFGPFVYFNVQKTKYLQMLTAAFRWMAFTLMIC 262
            .|.:.|.:..||  ..:.|::.||:.|..|||:.|||.:|:||||||||:||:..||:||.:||.
Human   188 ADTKYNDTDRCW--GPLRRVDAYRIYLAIFTLLLGPFTFFDVQKTKYLQILTSLMRWIAFAVMIV 250

  Fly   263 ISLKLLISRG-AKGHPATFNVYGIPSLFGACVYSFMCHHSLPSLLAPIRHKSMVSKILSIDYIII 326
            ::| :.|..| .:|||...:..|:.:|||.|||||||.||||||:.|:..|..:::::.:||::|
Human   251 LAL-IRIGHGQGEGHPPLADFSGVRNLFGVCVYSFMCQHSLPSLITPVSSKRHLTRLVFLDYVLI 314

  Fly   327 CAFYILLAMTGIFAF--ERIEDLYTLDFLPYDVAYVDFWSGLLICIDYFLALFPIFTLSTSFPIV 389
            .|||.||:.|.||.|  :.:.|:|||:|...||..       |..:.:||.|||:||:||:|||:
Human   315 LAFYGLLSFTAIFCFRGDSLMDMYTLNFARCDVVG-------LAAVRFFLGLFPVFTISTNFPII 372

  Fly   390 AITLKNNLQSLFLDMSQYESYS-VILRLCFPLLAIIPPFCITYFTESLSSLVAFTGTYAGTGIQY 453
            |:||:||.::||  ..:..:|. |:.|:.||.:.::||..:.:.|..|.|||..||.||||||||
Human   373 AVTLRNNWKTLF--HREGGTYPWVVDRVVFPTITLVPPVLVAFCTHDLESLVGITGAYAGTGIQY 435

  Fly   454 IIPVFLVYFARRTCSELLGSGVVNRFKSPFKSSAWLVFVFIWSILCVCLVSINL 507
            :||.||||..||......|.||.|:.:|||:.:.|:.||.:|:..|...|:.|:
Human   436 VIPAFLVYHCRRDTQLAFGCGVSNKHRSPFRHTFWVGFVLLWAFSCFIFVTANI 489

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5262	NP_649223.1	SLC5-6-like_sbd	15..502	CDD:444915	217/496 (44%)
TMEM104	NP_060198.3	SLC5-6-like_sbd	<209..443	CDD:444915	115/243 (47%)